A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee
Public ClinicalTrials.gov record NCT00396955. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind Comparison of 4 Dose Regimens of Pla-695, Naproxen, and Placebo Administered Daily for 6 Weeks in Subjects With Active Osteoarthritis of the Knee
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Objectives: Primary:To assess the efficacy and safety of PLA-695 in subjects with active osteoarthritis (OA) of the knee. Secondary:To determine the pharmacokinetics (PK) and pharmacodynamics (PD) of PLA-695 among dose levels. To assess health outcome measures. To assess the effect of PLA-695 on biomarkers related to clinical responses. To assess PLA-695 exposure-response relationship on PD, efficacy, and safety measures. To assess pharmacogenomics (PGX) analysis in OA.
Study identification
- NCT ID
- NCT00396955
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 560 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2006 (Type not available)
- Primary completion
- Nov 2007 (Actual)
- Completion
- Nov 2007 (Actual)
- Last update posted
- Dec 28, 2007
2006 – 2007
United States locations
- U.S. sites
- 39
- U.S. states
- 21
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Huntsville | Alabama | 35801 | — |
| Not listed | Scottsdale | Arizona | 85251 | — |
| Not listed | Tucson | Arizona | 85704 | — |
| Not listed | Tucson | Arizona | — | — |
| Not listed | Palo Alto | California | 94304 | — |
| Not listed | Rancho Mirage | California | 92270 | — |
| Not listed | Santa Maria | California | 93455 | — |
| Not listed | Upland | California | 91786 | — |
| Not listed | Delray Beach | Florida | 33484 | — |
| Not listed | Fort Lauderdale | Florida | 33334 | — |
| Not listed | Ocala | Florida | 34474 | — |
| Not listed | Palm Harbor | Florida | 34684 | — |
| Not listed | South Miami | Florida | 33143 | — |
| Not listed | Tampa | Florida | 33614 | — |
| Not listed | Idaho Falls | Idaho | 83401 | — |
| Not listed | Chicago | Illinois | 60611 | — |
| Not listed | Wichita | Kansas | 67208 | — |
| Not listed | Baltimore | Maryland | 21224 | — |
| Not listed | Frederick | Maryland | 21702 | — |
| Not listed | Fall River | Massachusetts | 02720 | — |
| Not listed | Kalamazoo | Michigan | 49048 | — |
| Not listed | St Louis | Missouri | 63128 | — |
| Not listed | Las Vegas | Nevada | — | — |
| Not listed | Dover | New Hampshire | 03820 | — |
| Not listed | Mamaroneck | New York | 10543 | — |
| Not listed | Syracuse | New York | 13210 | — |
| Not listed | Charlotte | North Carolina | 28210 | — |
| Not listed | Duncansville | Pennsylvania | 16635 | — |
| Not listed | West Reading | Pennsylvania | 19611 | — |
| Not listed | Willow Grove | Pennsylvania | 19090 | — |
| Not listed | Charleston | South Carolina | 29406 | — |
| Not listed | Dallas | Texas | 75231 | — |
| Not listed | Dallas | Texas | 75235 | — |
| Not listed | San Antonio | Texas | 78217 | — |
| Not listed | Salt Lake City | Utah | 84107 | — |
| Not listed | Seattle | Washington | 98166 | — |
| Not listed | Spokane | Washington | 99204 | — |
| Not listed | Tacoma | Washington | 98405 | — |
| Not listed | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 44 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00396955, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 28, 2007 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00396955 live on ClinicalTrials.gov.