A Study of ABT-263 in Subjects With Relapsed or Refractory Lymphoid Malignancies
Public ClinicalTrials.gov record NCT00406809. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2a Study Evaluating the Safety, Pharmacokinetics and Efficacy of ABT-263 in Subjects With Relapsed or Refractory Lymphoid Malignancies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The Phase 1 portion of the study evaluated the pharmacokinetic profile and safety of ABT-263 with the objective of defining the dose limiting toxicity and maximum tolerated dose in subjects with lymphoid malignancies. The Phase 2a portion of the study is evaluating ABT-263 using a step-up dosing regimen and may be increased to the defined recommended Phase 2 dose to obtain additional safety information and a preliminary assessment of efficacy in subject with lymphoid malignancies. The Extension portion of the study is to allow Phase 2a subjects who remain active 1 year after the last subject enrolls or who have been on study approximately 1 year to continue receiving ABT-263 with less frequent study evaluations. Subjects in the Extension Study will continue receiving study drug for up to 7 years after the last subject transitions to the Extension Study, or until disease progression or toxicity that necessitates discontinuation (whichever comes first).
Study identification
- NCT ID
- NCT00406809
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 81 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 31, 2006
- Primary completion
- Sep 30, 2016
- Completion
- Sep 30, 2016
- Last update posted
- Aug 1, 2021
2006 – 2016
United States locations
- U.S. sites
- 11
- U.S. states
- 4
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Site Reference ID/Investigator# 4997 | Los Angeles | California | 90033 | — |
| Site Reference ID/Investigator# 9104 | Los Angeles | California | 90095 | — |
| Site Reference ID/Investigator# 2613 | Bethesda | Maryland | 20892 | — |
| Site Reference ID/Investigator# 40243 | Boston | Massachusetts | 02215 | — |
| Site Reference ID/Investigator# 4745 | Boston | Massachusetts | 02215 | — |
| Site Reference ID/Investigator# 2628 | Buffalo | New York | 14263 | — |
| Site Reference ID/Investigator# 23543 | New York | New York | 10016 | — |
| Site Reference ID/Investigator# 2627 | New York | New York | 10021 | — |
| Site Reference ID/Investigator# 2614 | New York | New York | 10032 | — |
| Site Reference ID/Investigator# 5383 | New York | New York | 10065 | — |
| Site Reference ID/Investigator# 12306 | Rochester | New York | 14642 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00406809, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 1, 2021 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00406809 live on ClinicalTrials.gov.