Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer
Public ClinicalTrials.gov record NCT00408694. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CRT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) for Locally or Regionally Advanced Nasopharyngeal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II trial is studying how well giving bevacizumab together with cisplatin, radiation therapy, and fluorouracil works in treating patients with stage IIB, stage III, stage IVA, or stage IVB nasopharyngeal cancer. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of nasopharyngeal cancer by blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving bevacizumab together with chemotherapy and radiation therapy may kill more tumor cells.
Study identification
- NCT ID
- NCT00408694
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 46 participants
Conditions and interventions
Conditions
- Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7
- Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7
- Stage III Nasopharyngeal Undifferentiated Carcinoma AJCC v7
- Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7
- Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7
Interventions
- 3-Dimensional Conformal Radiation Therapy Radiation
- Bevacizumab Biological
- Cisplatin Drug
- Fluorouracil Drug
- Intensity-Modulated Radiation Therapy Radiation
Radiation · Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2006 (Actual)
- Primary completion
- Dec 15, 2011 (Actual)
- Completion
- Dec 15, 2011 (Actual)
- Last update posted
- Jan 30, 2018
2006 – 2011
United States locations
- U.S. sites
- 104
- U.S. states
- 22
- U.S. cities
- 80
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| Mercy San Juan Medical Center | Carmichael | California | 95608 | — |
| East Bay Radiation Oncology Center | Castro Valley | California | 94546 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| Valley Medical Oncology Consultants-Castro Valley | Castro Valley | California | 94546 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Bay Area Breast Surgeons Inc | Emeryville | California | 94608 | — |
| Valley Medical Oncology Consultants-Fremont | Fremont | California | 94538 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| Highland General Hospital | Oakland | California | 94602 | — |
| Alta Bates Summit Medical Center - Summit Campus | Oakland | California | 94609 | — |
| Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Hematology and Oncology Associates-Oakland | Oakland | California | 94609 | — |
| Tom K Lee Inc | Oakland | California | 94609 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Valley Care Health System - Pleasanton | Pleasanton | California | 94588 | — |
| Valley Medical Oncology Consultants | Pleasanton | California | 94588 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| Mercy General Hospital Radiation Oncology Center | Sacramento | California | 95819 | — |
| Doctors Medical Center- JC Robinson Regional Cancer Center | San Pablo | California | 94806 | — |
| Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | 95687 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Integrated Community Oncology Network-Southside Cancer Center | Jacksonville | Florida | 32207 | — |
| Baptist Medical Center South | Jacksonville | Florida | 32258 | — |
| Integrated Community Oncology Network-Florida Cancer Center Beaches | Jacksonville Beach | Florida | 32250 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176 | — |
| 21st Century Oncology-Orange Park | Orange Park | Florida | 32073 | — |
| UF Cancer Center at Orlando Health | Orlando | Florida | 32806 | — |
| 21st Century Oncology-Palatka | Palatka | Florida | 32177 | — |
| Integrated Community Oncology Network-Flager Cancer Center | Saint Augustine | Florida | 32086 | — |
| Memorial University Medical Center | Savannah | Georgia | 31404 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Saint Vincent Anderson Regional Hospital/Cancer Center | Anderson | Indiana | 46016 | — |
| Union Hospital of Cecil County | Elkton | Maryland | 21921 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Spectrum Health Big Rapids Hospital | Big Rapids | Michigan | 49307 | — |
| Cancer Research Consortium of West Michigan NCORP | Grand Rapids | Michigan | 49503 | — |
| Mercy Health Saint Mary's | Grand Rapids | Michigan | 49503 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| Holland Community Hospital | Holland | Michigan | 49423 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49001 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Mercy Health Partners-Hackley Campus | Muskegon | Michigan | 49442 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Metro Health Hospital | Wyoming | Michigan | 49519 | — |
| Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Virtua Memorial | Mount Holly | New Jersey | 08060 | — |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07101 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Beth Israel Medical Center | New York | New York | 10003 | — |
| Saint Luke's Roosevelt Hospital Center - Saint Luke's Division | New York | New York | 10025 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| UPMC Cancer Center at Clarion Hospital | Clarion | Pennsylvania | 16214 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | 15901 | — |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | — |
| Upper Delaware Valley Cancer Center | Milford | Pennsylvania | 18337 | — |
| UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon Township | Pennsylvania | 15108 | — |
| UPMC Cancer Center-Natrona Heights | Natrona Heights | Pennsylvania | 15065 | — |
| UPMC Jameson | New Castle | Pennsylvania | 16105 | — |
| Radiation Therapy Oncology Group | Philadelphia | Pennsylvania | 19103 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Jefferson Regional Radiation Oncology | Pittsburgh | Pennsylvania | 15236 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | 15401 | — |
| UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | 15301 | — |
| AnMed Health Hospital | Anderson | South Carolina | 29621 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Wilford Hall Medical Center | Lackland Air Force Base | Texas | 78236 | — |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00408694, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 30, 2018 · Synced Oct 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00408694 live on ClinicalTrials.gov.