Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT00420927. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Period, Double - Blind Study to Determine the Optimal Protocol for Treatment Initiation With Methotrexate and Adalimumab Combination Therapy in Patients With Early Rheumatoid Arthritis (OPTIMA)
Study identification
- NCT ID
- NCT00420927
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Abbott
- Industry
- Enrollment
- 1,032 participants
Conditions and interventions
Conditions
Interventions
- adalimumab Biological
- methotrexate Drug
- placebo Biological
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2006
- Primary completion
- Jun 30, 2010
- Completion
- Jun 30, 2010
- Last update posted
- Apr 17, 2012
2006 – 2010
United States locations
- U.S. sites
- 49
- U.S. states
- 21
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Site Reference ID/Investigator# 4560 | Birmingham | Alabama | 35205 | — |
| Site Reference ID/Investigator# 4547 | Birmingham | Alabama | 35294-7201 | — |
| Site Reference ID/Investigator# 6222 | Huntsville | Alabama | 35801 | — |
| Site Reference ID/Investigator# 4537 | Mobile | Alabama | 36608 | — |
| Site Reference ID/Investigator# 6758 | Tuscaloosa | Alabama | 35406 | — |
| Site Reference ID/Investigator# 9323 | Hemet | California | 92543 | — |
| Site Reference ID/Investigator# 4568 | La Jolla | California | 92037-0943 | — |
| Site Reference ID/Investigator# 4535 | Palm Desert | California | 92260 | — |
| Site Reference ID/Investigator# 4571 | Santa Monica | California | 90404 | — |
| Site Reference ID/Investigator# 9271 | Torrance | California | 90505 | — |
| Site Reference ID/Investigator# 10746 | Victorville | California | 92395 | — |
| Site Reference ID/Investigator# 4559 | Denver | Colorado | 80230 | — |
| Site Reference ID/Investigator# 6229 | Aventura | Florida | 33180 | — |
| Site Reference ID/Investigator# 10603 | Lake Mary | Florida | 32746 | — |
| Site Reference ID/Investigator# 9325 | Orange Park | Florida | 32073 | — |
| Site Reference ID/Investigator# 4550 | Palm Harbor | Florida | 34684 | — |
| Site Reference ID/Investigator# 4570 | Sarasota | Florida | 34239 | — |
| Site Reference ID/Investigator# 4601 | Tampa | Florida | 33614 | — |
| Site Reference ID/Investigator# 4552 | Vero Beach | Florida | 32960 | — |
| Site Reference ID/Investigator# 10745 | Meridian | Idaho | 83642 | — |
| Site Reference ID/Investigator# 4548 | Chicago | Illinois | 60612 | — |
| Site Reference ID/Investigator# 4557 | Springfield | Illinois | 62704 | — |
| Site Reference ID/Investigator# 4605 | Wichita | Kansas | 67203 | — |
| Site Reference ID/Investigator# 10741 | Wheaton | Maryland | 20902 | — |
| Site Reference ID/Investigator# 6417 | Fall River | Massachusetts | 02720 | — |
| Site Reference ID/Investigator# 4561 | Dover | New Hampshire | 03820 | — |
| Site Reference ID/Investigator# 11222 | Freehold | New Jersey | 07728 | — |
| Site Reference ID/Investigator# 6228 | Passaic | New Jersey | 07055 | — |
| Site Reference ID/Investigator# 4544 | Albuquerque | New Mexico | 87102 | — |
| Site Reference ID/Investigator# 4534 | Orchard Park | New York | 14127 | — |
| Site Reference ID/Investigator# 9324 | Plainview | New York | 11803 | — |
| Site Reference ID/Investigator# 4600 | Smithtown | New York | 11787 | — |
| Site Reference ID/Investigator# 12821 | The Bronx | New York | 10461 | — |
| Site Reference ID/Investigator# 4549 | Mayfield Village | Ohio | 44143 | — |
| Site Reference ID/Investigator# 6227 | Bend | Oregon | 97701 | — |
| Site Reference ID/Investigator# 4546 | Duncansville | Pennsylvania | 16635 | — |
| Site Reference ID/Investigator# 4564 | West Reading | Pennsylvania | 19611-1124 | — |
| Site Reference ID/Investigator# 4558 | Wexford | Pennsylvania | 15090 | — |
| Site Reference ID/Investigator# 4533 | Charleston | South Carolina | 29406 | — |
| Site Reference ID/Investigator# 7482 | Greenville | South Carolina | 29601 | — |
| Site Reference ID/Investigator# 10743 | Jackson | Tennessee | 38305 | — |
| Site Reference ID/Investigator# 4562 | Nashville | Tennessee | 37205 | — |
| Site Reference ID/Investigator# 4536 | Dallas | Texas | 75231 | — |
| Site Reference ID/Investigator# 4538 | Houston | Texas | 77074 | — |
| Site Reference ID/Investigator# 6899 | San Antonio | Texas | 78217 | — |
| Site Reference ID/Investigator# 6381 | Tyler | Texas | 75701 | — |
| Site Reference ID/Investigator# 10744 | Seattle | Washington | 98133 | — |
| Site Reference ID/Investigator# 4545 | Glendale | Wisconsin | 53217 | — |
| Site Reference ID/Investigator# 4572 | Oak Creek | Wisconsin | 53154 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 121 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00420927, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 17, 2012 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00420927 live on ClinicalTrials.gov.