Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)
Public ClinicalTrials.gov record NCT00423319. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Double-blind, Active-controlled, Parallel-group, Multi-center Study to Evaluate the Safety and Efficacy of Apixaban in Subjects Undergoing Elective Total Hip Replacement Surgery (The Advance-3 Study Apixaban Dosed Orally Versus Anticoagulation With Injectable Enoxaparin to Prevent Venous Thromboembolism)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn whether apixaban can prevent the blood clots in the leg (deep vein thrombosis) and lung (pulmonary embolism) that sometimes occur after hip replacement surgery and to learn how apixaban compares with enoxaparin in preventing these clots. The safety of apixaban will also be studied
Study identification
- NCT ID
- NCT00423319
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 5,407 participants
Conditions and interventions
Conditions
Interventions
- Enoxaparin Drug
- Apixaban Drug
- Enoxaparin-matching placebo Drug
- Apixaban-matching placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2007 (Type not available)
- Primary completion
- Sep 2009 (Actual)
- Completion
- Sep 2009 (Actual)
- Last update posted
- May 14, 2014
2007 – 2009
United States locations
- U.S. sites
- 19
- U.S. states
- 9
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Capstone Clinical Trials, Inc | Birmingham | Alabama | 35209 | — |
| West Alabama Research, Llc | Birmingham | Alabama | 35209 | — |
| Martin Bowen Hefley Orthopedics | Little Rock | Arkansas | 72205 | — |
| Orthoarkansas, P.A. | Little Rock | Arkansas | 72205 | — |
| Uc Davis Medical Center | Sacramento | California | 95817 | — |
| Colorado Orthopedic Consultants, Pc | Aurora | Colorado | 80012 | — |
| Advanced Orthopedic And Sports Medicine Specilists | Denver | Colorado | 80230 | — |
| Denver-Vail Orthopedics, P.C. | Denver | Colorado | 80230 | — |
| Pab Clinical Research | Brandon | Florida | 33511 | — |
| Research Alliance, Inc. | Clearwater | Florida | 33756 | — |
| Shrock Orthopedic Research | Fort Lauderdale | Florida | 33316 | — |
| Phoenix Clinical Research, Llc | Tamarac | Florida | 33321 | — |
| Atlanta Knee And Sports Medicine | Decatur | Georgia | 30033 | — |
| Americana Orthopedics | Boise | Idaho | 83702 | — |
| Bosie Orthopedic Clinic | Meridian | Idaho | 83642 | — |
| University Orthopedic Center | Altoona | Pennsylvania | 16602 | — |
| Gill Orthopedic Center | Lubbock | Texas | 79410 | — |
| Robert R. King, Md | Lubbock | Texas | 79410 | — |
| Unlimited Research | San Antonio | Texas | 78217 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 124 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00423319, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2014 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00423319 live on ClinicalTrials.gov.