Efficacy, Safety and Tolerability of ACZ885 in Patients With Active Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT00424346. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Dose-finding Study to Evaluate the Efficacy, Safety and Tolerability of ACZ885 (Anti-interleukin-1beta Monoclonal Antibody) With Three Different Dose Regimens in Patients With Active Rheumatoid Arthritis Despite Stable Treatment With Methotrexate Including 76-week and 96-week Extensions
Study identification
- NCT ID
- NCT00424346
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Novartis
- Industry
- Enrollment
- 274 participants
Conditions and interventions
Conditions
Interventions
- Canakinumab Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 31, 2006
- Primary completion
- Aug 31, 2008
- Completion
- Sep 30, 2009
- Last update posted
- Feb 9, 2014
2006 – 2009
United States locations
- U.S. sites
- 12
- U.S. states
- 8
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Sun Valley Arthritis Center, Ltd | Peoria | Arizona | 85381 | — |
| Catalina Pointe Arthritis & Rheumatology Specialists | Tucson | Arizona | 85704 | — |
| Arthritis Center | Palm Harbor | Florida | 34684 | — |
| Arthritis Research of Florida, Inc. | Palm Harbor | Florida | 34684 | — |
| The Arthritis Center | Springfield | Illinois | 62704 | — |
| St. Louis Cener for Clinical Research | St Louis | Missouri | 63128 | — |
| The Center for Rheumatology | Albany | New York | 12206 | — |
| AAIR Research Center | Rochester | New York | 14618 | — |
| Oregon Health Sciences University | Portland | Oregon | 97239 | — |
| Tacoma Center for Arthritis Research | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00424346, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2014 · Synced Jul 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00424346 live on ClinicalTrials.gov.