ClinicalTrials.gov record
Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer
ClinicalTrials.gov ID: NCT00430183
Public ClinicalTrials.gov record NCT00430183. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients With High-Risk, Clinically Localized Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as goserelin and leuprolide, may stop the adrenal glands from making androgens. Giving docetaxel and leuprolide or goserelin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known whether giving docetaxel and leuprolide or goserelin before surgery is more effective than surgery alone in treating patients with prostate cancer. PURPOSE: This randomized phase III trial is studying docetaxel and leuprolide or goserelin to see how well they work when given before surgery compared with surgery alone in treating patients with high-risk localized prostate cancer.
Study identification
- NCT ID
- NCT00430183
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 788 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 8, 2007 (Actual)
- Primary completion
- Oct 2, 2018 (Actual)
- Completion
- Oct 2030 (Estimated)
- Last update posted
- Feb 9, 2023
2007 – 2030
United States locations
- U.S. sites
- 221
- U.S. states
- 40
- U.S. cities
- 169
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Providence Cancer Center | Anchorage | Alaska | 99508 | — |
| Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital | Fairbanks | Alaska | 99701 | — |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley | California | 94704 | — |
| Peninsula Medical Center | Burlingame | California | 94010 | — |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | 90089-9181 | — |
| Sutter Health - Western Division Cancer Research Group | Novato | California | 94945 | — |
| University of California Davis Cancer Center | Sacramento | California | 95817 | — |
| Naval Medical Center - San Diego | San Diego | California | 92134 | — |
| California Pacific Medical Center - Pacific Campus | San Francisco | California | 94118 | — |
| Sutter Pacific Medical Foundation | Santa Rosa | California | 95403 | — |
| Tahoe Forest Cancer Center | Truckee | California | 96161 | — |
| Sutter Solano Medical Center | Vallejo | California | 94589 | — |
| University of Colorado Cancer Center at UC Health Sciences Center | Aurora | Colorado | 80045 | — |
| Denver Health Medical Center | Denver | Colorado | 80204 | — |
| Veterans Affairs Medical Center - Denver | Denver | Colorado | 80220 | — |
| Shaw Regional Cancer Center | Edwards | Colorado | 81632 | — |
| Valley View Hospital Cancer Center | Glenwood Springs | Colorado | 81601 | — |
| Montrose Memorial Hospital Cancer Center | Montrose | Colorado | 81401 | — |
| Helen and Harry Gray Cancer Center at Hartford Hospital | Hartford | Connecticut | 06102-5037 | — |
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford | Connecticut | 06105 | — |
| Yale Cancer Center | New Haven | Connecticut | 06520-8028 | — |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Veterans Affairs Medical Center - West Haven | West Haven | Connecticut | 06516 | — |
| Tunnell Cancer Center at Beebe Medical Center | Lewes | Delaware | 19958 | — |
| CCOP - Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter | Florida | 33458 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando | Florida | 32803-1273 | — |
| H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | Tampa | Florida | 33612-9497 | — |
| Cleveland Clinic Florida - Weston | Weston | Florida | 33331 | — |
| OnCare Hawaii, Incorporated - Lusitana | Honolulu | Hawaii | 96813 | — |
| Queen's Cancer Institute at Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| Straub Clinic and Hospital, Incorporated | Honolulu | Hawaii | 96813 | — |
| Hawaii Medical Center - East | Honolulu | Hawaii | 96817 | — |
| OnCare Hawaii, Incorporated - Kuakini | Honolulu | Hawaii | 96817 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Castle Medical Center | Kailua | Hawaii | 96734 | — |
| Kauai Medical Clinic | Lihue | Hawaii | 96766 | — |
| Maui Memorial Medical Center | Wailuku | Hawaii | 96793 | — |
| Pacific Cancer Institute - Maui | Wailuku | Hawaii | 96793 | — |
| Kapiolani Medical Center at Pali Momi | ‘Aiea | Hawaii | 96701 | — |
| Idaho Urologic Institute, PA | Meridian | Idaho | 83642 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637-1470 | — |
| Louis A. Weiss Memorial Hospital | Chicago | Illinois | 60640 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Delnor Hospital - Geneva | Geneva | Illinois | 60134 | — |
| Veterans Affairs Medical Center - Hines | Hines | Illinois | 60141 | — |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Regional Cancer Center at Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Central Dupage Cancer Center | Warrenville | Illinois | 60555 | — |
| Elkhart Clinic, LLC | Elkhart | Indiana | 46514-2098 | — |
| Michiana Hematology-Oncology, PC - Elkhart | Elkhart | Indiana | 46514 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46515 | — |
| Howard Community Hospital | Kokomo | Indiana | 46904 | — |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | 46350 | — |
| Michiana Hematology-Oncology, PC - South Bend | Mishawaka | Indiana | 46545-1470 | — |
| Saint Joseph Regional Medical Center | Mishawaka | Indiana | 46545-1470 | — |
| Michiana Hematology Oncology PC - Plymouth | Plymouth | Indiana | 46563 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Michiana Hematology Oncology PC - La Porte | Westville | Indiana | 46391 | — |
| Hematology Oncology Associates of the Quad Cities | Bettendorf | Iowa | 52722 | — |
| Genesis Regional Cancer Center at Genesis Medical Center | Davenport | Iowa | 52803 | — |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | 52242-1002 | — |
| St. Rose Ambulatory and Surgery Center | Great Bend | Kansas | 67530 | — |
| Hays Medical Center | Hays | Kansas | 67601 | — |
| Hutchinson Hospital Corporation | Hutchinson | Kansas | 67502 | — |
| Kansas City Cancer Centers - West | Kansas City | Kansas | 66112 | — |
| Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | Kansas City | Kansas | 66160-7357 | — |
| Kansas City Cancer Centers - Southwest | Overland Park | Kansas | 66210 | — |
| Mount Carmel Regional Cancer Center | Pittsburg | Kansas | 66762 | — |
| Tammy Walker Cancer Center at Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Kansas City Cancer Center - Shawnee Mission | Shawnee Mission | Kansas | 66204 | — |
| St. Francis Comprehensive Cancer Center | Topeka | Kansas | 66606 | — |
| Pennington Cancer Center at Baton Rouge General | Baton Rouge | Louisiana | 70806 | — |
| Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Medical Center of Louisiana - New Orleans | New Orleans | Louisiana | 70112 | — |
| Maine Center for Cancer Medicine and Blood Disorders - Scarborough | Scarborough | Maine | 04074 | — |
| Union Hospital of Cecil County | Elkton | Maryland | 21921 | — |
| Peninsula Regional Medical Center | Salisbury | Maryland | 21801 | — |
| Tufts Medical Center Cancer Center | Boston | Massachusetts | 02111 | — |
| Berkshire Hematology Oncology, PC | Pittsfield | Massachusetts | 01201 | — |
| Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | 48106-0995 | — |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48106 | — |
| Mecosta County Medical Center | Big Rapids | Michigan | 49307 | — |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | 48123-2500 | — |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| CCOP - Grand Rapids | Grand Rapids | Michigan | 49503 | — |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | 48236 | — |
| Foote Memorial Hospital | Jackson | Michigan | 49201 | — |
| Sparrow Regional Cancer Center | Lansing | Michigan | 48912-1811 | — |
| St. Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Mercy General Health Partners | Muskegon | Michigan | 49444 | — |
| St. Joseph Mercy Oakland | Pontiac | Michigan | 48341-2985 | — |
| Mercy Regional Cancer Center at Mercy Hospital | Port Huron | Michigan | 48060 | — |
| Spectrum Health Reed City Hospital | Reed City | Michigan | 49677 | — |
| Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw | Michigan | 48601 | — |
| Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| Lakeside Cancer Specialists, PLLC | Saint Joseph | Michigan | 49085 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| St. John Macomb Hospital | Warren | Michigan | 48093 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley | Minnesota | 55432 | — |
| Hutchinson Area Health Care | Hutchinson | Minnesota | 55350 | — |
| HealthEast Cancer Care at St. John's Hospital | Maplewood | Minnesota | 55109 | — |
| Minnesota Oncology - Maplewood | Maplewood | Minnesota | 55109 | — |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | 55415 | — |
| Masonic Cancer Center at University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | — |
| Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | 55422-2900 | — |
| CentraCare Clinic - River Campus | Saint Cloud | Minnesota | 56303 | — |
| Coborn Cancer Center | Saint Cloud | Minnesota | 56303 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Cancer Center | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital Cancer Care Center | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee | Minnesota | 55379 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Willmar Cancer Center at Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology - Woodbury | Woodbury | Minnesota | 55125 | — |
| University of Mississippi Cancer Clinic | Jackson | Mississippi | 39216 | — |
| Truman Medical Center - Hospital Hill | Kansas City | Missouri | 64108 | — |
| Veterans Affairs Medical Center - Kansas City | Kansas City | Missouri | 64128 | — |
| Kansas City Cancer Centers - South | Kansas City | Missouri | 64131 | — |
| Kansas City Cancer Centers - North | Kansas City | Missouri | 64154 | — |
| Kansas City Cancer Centers - East | Lee's Summit | Missouri | 64064 | — |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St Louis | Missouri | 63110 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| St. Vincent Healthcare Cancer Care Services | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies - Billings | Billings | Montana | 59102 | — |
| Billings Clinic | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| St. James Healthcare Cancer Care | Butte | Montana | 59701 | — |
| Benefis Healthcare - Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic - Main Facility | Great Falls | Montana | 59405 | — |
| St. Peter's Hospital | Helena | Montana | 59601 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Montana Cancer Specialists at Montana Cancer Center | Missoula | Montana | 59807-7877 | — |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula | Montana | 59807 | — |
| CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| Methodist Estabrook Cancer Center | Omaha | Nebraska | 68114 | — |
| Immanuel Medical Center | Omaha | Nebraska | 68122 | — |
| Lakeside Hospital | Omaha | Nebraska | 68130 | — |
| Creighton University Medical Center | Omaha | Nebraska | 68131-2197 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| CCOP - Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | Concord | New Hampshire | 03301 | — |
| New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett | New Hampshire | 03106 | — |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756-0002 | — |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton | New Jersey | 08053 | — |
| Carol G. Simon Cancer Center at Morristown Memorial Hospital | Morristown | New Jersey | 07960 | — |
| Somerset Medical Center | Somerville | New Jersey | 08876 | — |
| Frederick R. and Betty M. Smith Cancer Treatment Center | Sparta | New Jersey | 07871 | — |
| Overlook Hospital | Summit | New Jersey | 07901 | — |
| Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees Township | New Jersey | 08043 | — |
| Hematology Oncology Associates, PC | Albuquerque | New Mexico | 87106 | — |
| Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital | Albuquerque | New Mexico | 87110 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87131-5636 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263-0001 | — |
| New York Weill Cornell Cancer Center at Cornell University | New York | New York | 10021 | — |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University Hospital | Syracuse | New York | 13210 | — |
| Veterans Affairs Medical Center - Syracuse | Syracuse | New York | 13210 | — |
| Presbyterian Cancer Center at Presbyterian Hospital | Charlotte | North Carolina | 28233-3549 | — |
| Duke Cancer Institute | Durham | North Carolina | 27710 | — |
| Wayne Memorial Hospital, Incorporated | Goldsboro | North Carolina | 27534 | — |
| Kinston Medical Specialists | Kinston | North Carolina | 28501 | — |
| Carolinas Medical Center - Union | Monroe | North Carolina | 28112 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Cleveland Regional Medical Center | Shelby | North Carolina | 28150 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Forsyth Regional Cancer Center at Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest University Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157-1096 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| St. Rita's Medical Center | Lima | Ohio | 45801 | — |
| Oklahoma University Cancer Institute | Oklahoma City | Oklahoma | 73104 | — |
| Bay Area Hospital | Coos Bay | Oregon | 97420 | — |
| Kaiser Permanente Health Care - Portland | Portland | Oregon | 97227 | — |
| Mercy Fitzgerald Hospital | Darby | Pennsylvania | 19023 | — |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107-5541 | — |
| Fox Chase Cancer Center - Philadelphia | Philadelphia | Pennsylvania | 19111-2497 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| Roper St. Francis Cancer Center at Roper Hospital | Charleston | South Carolina | 29401 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29303 | — |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | Kingsport | Tennessee | 37662 | — |
| MBCCOP - Meharry Medical College - Nashville | Nashville | Tennessee | 37208-3599 | — |
| Mountainview Medical | Berlin Corners | Vermont | 05602 | — |
| Fletcher Allen Health Care - University Health Center Campus | Burlington | Vermont | 05401 | — |
| Lynchburg Hematology-Oncology Clinic | Lynchburg | Virginia | 24501 | — |
| Southwest Virginia Regional Cancer Center at Wellmonth Health | Norton | Virginia | 24273 | — |
| Providence Centralia Hospital | Centralia | Washington | 98531-9027 | — |
| St. Francis Hospital | Federal Way | Washington | 98003 | — |
| Cascade Cancer Center at Evergreen Hospital Medical Center | Kirkland | Washington | 98033 | — |
| Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington | 98034 | — |
| Providence St. Peter Hospital Regional Cancer Center | Olympia | Washington | 98506-5166 | — |
| Good Samaritan Cancer Center | Puyallup | Washington | 98372 | — |
| CCOP - Virginia Mason Research Center | Seattle | Washington | 98101 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Pacific Medical Center | Seattle | Washington | 98104 | — |
| Rockwood Clinic Cancer Treatment Center | Spokane | Washington | 99204-2967 | — |
| Franciscan Cancer Center at St. Joseph Medical Center | Tacoma | Washington | 98405-3004 | — |
| CCOP - Northwest | Tacoma | Washington | 98405 | — |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma | Washington | 98405 | — |
| Madigan Army Medical Center - Tacoma | Tacoma | Washington | 98431 | — |
| St. Clare Hospital | Tacoma | Washington | 98499 | — |
| West Virginia University Health Sciences Center - Charleston | Charleston | West Virginia | 25304 | — |
| Edwards Comprehensive Cancer Center at Cabell Huntington Hospital | Huntington | West Virginia | 25701 | — |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse | Wisconsin | 54601 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center at Sheridan Memorial Hospital | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00430183, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2023 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00430183 live on ClinicalTrials.gov.