Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma
Public ClinicalTrials.gov record NCT00433381. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II Trial of Bevacizumab With Irinotecan or Bevacizumab With Temozolomide in Recurrent Glioblastoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase II trial is studying the side effects and how well giving bevacizumab together with irinotecan or temozolomide works in treating patients with recurrent or refractory glioblastoma multiforme or gliosarcoma. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bevacizumab together with irinotecan or temozolomide may kill more tumor cells.
Study identification
- NCT ID
- NCT00433381
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 123 participants
Conditions and interventions
Interventions
- Bevacizumab Biological
- Irinotecan Hydrochloride Drug
- Temozolomide Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2007 (Actual)
- Primary completion
- Jan 21, 2010 (Actual)
- Completion
- Feb 16, 2011 (Actual)
- Last update posted
- Sep 17, 2018
2007 – 2011
United States locations
- U.S. sites
- 93
- U.S. states
- 29
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mobile Infirmary Medical Center | Mobile | Alabama | 36607 | — |
| Fairbanks Memorial Hospital | Fairbanks | Alaska | 99701 | — |
| Arizona Oncology Services Foundation | Scottsdale | Arizona | 85260 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Mills-Peninsula Medical Center | Burlingame | California | 94010 | — |
| John Muir Medical Center-Concord Campus | Concord | California | 94520 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Marin General Hospital | Greenbrae | California | 94904 | — |
| Sutter Cancer Research Consortium | Novato | California | 94945 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| Sutter Solano Medical Center/Cancer Center | Vallejo | California | 94589 | — |
| John Muir Medical Center-Walnut Creek | Walnut Creek | California | 94598 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| University of Florida Health Science Center - Gainesville | Gainesville | Florida | 32610 | — |
| Saint Luke's Mountain States Tumor Institute | Boise | Idaho | 83712 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Saint Vincent Anderson Regional Hospital/Cancer Center | Anderson | Indiana | 46016 | — |
| Franciscan Saint Francis Health-Beech Grove | Beech Grove | Indiana | 46107 | — |
| IU Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Reid Health | Richmond | Indiana | 47374 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49001 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | 48073 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview-Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| Cheshire Medical Center-Dartmouth-Hitchcock Keene | Keene | New Hampshire | 03431 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| John F Kennedy Medical Center | Edison | New Jersey | 08818 | — |
| New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | 87109 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Mission Hospital-Memorial Campus | Asheville | North Carolina | 28801 | — |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Health Center | Dayton | Ohio | 45415 | — |
| Dayton NCI Community Oncology Research Program | Dayton | Ohio | 45420 | — |
| Veteran Affairs Medical Center | Dayton | Ohio | 45428 | — |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Legacy Mount Hood Medical Center | Gresham | Oregon | 97030 | — |
| Providence Milwaukie Hospital | Milwaukie | Oregon | 97222 | — |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Adventist Medical Center | Portland | Oregon | 97216 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Legacy Emanuel Hospital and Health Center | Portland | Oregon | 97227 | — |
| Legacy Meridian Park Hospital | Tualatin | Oregon | 97062 | — |
| Radiation Therapy Oncology Group | Philadelphia | Pennsylvania | 19103 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | 84003 | — |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | — |
| Cottonwood Hospital Medical Center | Murray | Utah | 84107 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Intermountain Health Care | Salt Lake City | Utah | 84103 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | 84770 | — |
| Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | 05819 | — |
| Saint Francis Hospital | Federal Way | Washington | 98003 | — |
| EvergreenHealth Medical Center | Kirkland | Washington | 98033 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | 98664 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00433381, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2018 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00433381 live on ClinicalTrials.gov.