ClinicalTrials.gov record

Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

MVA Post-Event: Administration Timing and Boost Study

ClinicalTrials.gov ID: NCT00437021

Public ClinicalTrials.gov record NCT00437021. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 12:32 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Evaluation of IMVAMUNE® Smallpox Vaccine With Respect to Safety and Optimization of Immune Responses by Different Vaccination Regimens in Vaccinia-Naïve Adults

Study identification

NCT ID: NCT00437021
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Enrollment: 226 participants

Conditions and interventions

Conditions

Smallpox

Interventions

Live vaccinia virus vaccine Biological
MVA Smallpox Vaccine Biological
Placebo Other

Biological · Other

Eligibility (public fields only)

Age range: 18 Years to 38 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 15, 2007
Primary completion: Apr 20, 2009
Completion: Apr 20, 2009
Last update posted: Sep 18, 2025

2007 – 2009

United States locations

U.S. sites: 7
U.S. states: 7
U.S. cities: 7

Facility	City	State	ZIP	Site status
University of Iowa - Vaccine Research and Education Unit	Iowa City	Iowa	52242-2600	—
University of Maryland, School of Medicine, Center for Vaccine Development and Global Health	Baltimore	Maryland	21201-1509	—
Saint Louis University Center for Vaccine Development	St Louis	Missouri	63104-1015	—
University of Rochester Medical Center - Strong Memorial Hospital - Infectious Diseases	Rochester	New York	14642-0001	—
Duke Translational Medicine Institute - Clinical Vaccine Unit	Durham	North Carolina	27704-2120	—
Case Western Reserve University - John T. Carey Special Immunology Unit	Cleveland	Ohio	44106-3808	—
University of Texas Medical Branch - Pediatrics - Infectious Diseases and Immunology - Galveston	Galveston	Texas	77555-5302	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00437021, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 18, 2025 · Synced Jul 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT00437021 live on ClinicalTrials.gov.

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