Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema
Public ClinicalTrials.gov record NCT00444600. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination With Laser Photocoagulation for Diabetic Macular Edema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to find out which is a better treatment for diabetic macular edema (DME): laser alone, laser combined with an intravitreal injection of triamcinolone, laser combined with an intravitreal injection of ranibizumab, or intravitreal injection of ranibizumab alone. At the present time, it is not known whether intravitreal steroid or anti-vascular endothelial growth factor (anti-VEGF) injections, with or without laser treatment, are better than just laser by itself. It is possible that one or both of the types of injections, with or without laser treatment, will improve vision more often than will laser without injections. However, even if better vision outcomes are seen with injections, side effects may be more of a problem with the injections than with laser. Therefore, this study is conducted to find out whether the benefits of the injections will outweigh the risks.
Study identification
- NCT ID
- NCT00444600
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 691 participants
Conditions and interventions
Conditions
Interventions
- Triamcinolone Acetonide + laser Drug
- Ranibizumab + laser Drug
- Sham injection + laser Drug
- Ranibizumab + deferred laser Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2007 (Type not available)
- Primary completion
- Dec 2009 (Actual)
- Completion
- Feb 2014 (Actual)
- Last update posted
- Oct 7, 2019
2007 – 2014
United States locations
- U.S. sites
- 50
- U.S. states
- 22
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sall Research Medical Center | Artesia | California | 90701 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| University of California, Irvine | Irvine | California | 92697 | — |
| Loma Linda University Health Care, Dept. of Ophthalmology | Loma Linda | California | 92354 | — |
| Southern California Desert Retina Consultants, MC | Palm Springs | California | 92262 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Retina Vitreous Consultants | Fort Lauderdale | Florida | 33334 | — |
| Retina Consultants of Southwest Florida | Fort Myers | Florida | 33912 | — |
| University of Florida College of Med., Department of Ophthalmology | Jacksonville | Florida | 32209 | — |
| Central Florida Retina Institute | Lakeland | Florida | 33805 | — |
| Southeast Retina Center, P.C. | Augusta | Georgia | 30909 | — |
| Illinois Retina Associates | Joliet | Illinois | 60435 | — |
| Raj K. Maturi, M.D., P.C. | Indianapolis | Indiana | 46280 | — |
| John-Kenyon American Eye Institute | New Albany | Indiana | 47150 | — |
| Medical Associates Clinic, P.C. | Dubuque | Iowa | 52002 | — |
| Retina and Vitreous Associates of Kentucky | Lexington | Kentucky | 40509-1802 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Elman Retina Group, P.A. | Baltimore | Maryland | 21237 | — |
| Wilmer Eye Institute at Johns Hopkins | Baltimore | Maryland | 21287-9277 | — |
| Retina Consultants of Delmarva, P.A. | Salisbury | Maryland | 21801 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Retina Center, PA | Minneapolis | Minnesota | 55404 | — |
| Eyesight Ophthalmic Services, PA | Portsmouth | New Hampshire | 03801 | — |
| The New York Eye and Ear Infirmary/Faculty Eye Practice | New York | New York | 10003 | — |
| Retina-Vitreous Surgeons of Central New York, PC | Syracuse | New York | 13224 | — |
| University of North Carolina, Dept of Ophthalmology | Chapel Hill | North Carolina | 27599-7040 | — |
| Charlotte Eye, Ear, Nose and Throat Assoc., PA | Charlotte | North Carolina | 28210 | — |
| Wake Forest University Eye Center | Winston-Salem | North Carolina | 27157 | — |
| Retina Associates of Cleveland, Inc. | Beachwood | Ohio | 44122 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Retina Northwest, PC | Portland | Oregon | 97210 | — |
| Casey Eye Institute | Portland | Oregon | 97239 | — |
| Penn State College of Medicine | Hershey | Pennsylvania | 17033 | — |
| University of Pennsylvania Scheie Eye Institute | Philadelphia | Pennsylvania | 19104 | — |
| Retina Consultants | Providence | Rhode Island | 02903 | — |
| Palmetto Retina Center | Columbia | South Carolina | 29169 | — |
| Carolina Retina Center | Columbia | South Carolina | 29223 | — |
| Southeastern Retina Associates, PC | Kingsport | Tennessee | 37660 | — |
| Southeastern Retina Associates, P.C. | Knoxville | Tennessee | 37909 | — |
| West Texas Retina Consultants P.A. | Abilene | Texas | 79605 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Retina and Vitreous of Texas | Houston | Texas | 77025 | — |
| Vitreoretinal Consultants | Houston | Texas | 77030 | — |
| Texas Retina Associates | Lubbock | Texas | 79424 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| University of Wisconsin-Madison, Dept of Ophthalmology/Retina Service | Madison | Wisconsin | 53705 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00444600, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2019 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00444600 live on ClinicalTrials.gov.