ClinicalTrials.gov record
S0636: Erlotinib and Bevacizumab in Never-Smokers With Stage IIIB or Stage IV Primary Non-Small Cell Lung Cancer
ClinicalTrials.gov ID: NCT00445848
Public ClinicalTrials.gov record NCT00445848. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Trial of the Combination of OSI-774 (Erlotinib; NSC-718781) and Bevacizumab (RHUMAB VEGF; NSC 704865) in Never-Smokers With Stage IIIB and IV Primary NSCLC Adenocarcinomas
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab also may stop the growth of non-small cell lung cancer by blocking blood flow to the tumor. Giving erlotinib together with bevacizumab may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving erlotinib together with bevacizumab works in treating patients with stage IIIB or stage IV primary non-small cell lung cancer who have never smoked.
Study identification
- NCT ID
- NCT00445848
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 89 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2007 (Type not available)
- Primary completion
- Aug 2013 (Actual)
- Completion
- Jan 2014 (Actual)
- Last update posted
- Mar 5, 2020
2007 – 2014
United States locations
- U.S. sites
- 153
- U.S. states
- 21
- U.S. cities
- 112
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Kaiser Permanente - Deer Valley | Antioch | California | 94531 | — |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley | California | 94704 | — |
| Peninsula Medical Center | Burlingame | California | 94010 | — |
| Kaiser Permanente - Fremont | Fremont | California | 94538 | — |
| Marin Cancer Institute at Marin General Hospital | Greenbrae | California | 94904 | — |
| Kaiser Permanente Medical Center - Hayward | Hayward | California | 94545 | — |
| Tibotec Therapeutics - Division of Ortho Biotech Products, LP | Marysville | California | 95901 | — |
| Kaiser Permanente Medical Center - Oakland | Oakland | California | 94611 | — |
| Valley Medical Oncology Consultants - Pleasanton | Pleasanton | California | 94588 | — |
| Kaiser Permanente Medical Center - Redwood City | Redwood City | California | 94063 | — |
| Kaiser Permanente Medical Center - Richmond | Richmond | California | 94801 | — |
| Kaiser Permanente Medical Center - Roseville | Roseville | California | 95661 | — |
| University of California Davis Cancer Center | Sacramento | California | 95817 | — |
| South Sacramento Kaiser-Permanente Medical Center | Sacramento | California | 95823 | — |
| Kaiser Permanente Medical Center - Sacramento | Sacramento | California | 95825 | — |
| Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco | California | 94115 | — |
| California Pacific Medical Center - California Campus | San Francisco | California | 94118 | — |
| Kaiser Permanente Medical Center - Santa Teresa | San Jose | California | 95119 | — |
| Kaiser Foundation Hospital - San Rafael | San Rafael | California | 94903 | — |
| Sutter Health - Western Division Cancer Research Group | San Rafael | California | 94903 | — |
| Kaiser Permanente Medical Center - Santa Clara Kiely Campus | Santa Clara | California | 95051 | — |
| Kaiser Permanente Medical Center - Santa Rosa | Santa Rosa | California | 95403 | — |
| Kaiser Permanente Medical Center - South San Francisco | South San Francisco | California | 94080 | — |
| Kaiser Permanente Medical Facility - Stockton | Stockton | California | 95210 | — |
| Tahoe Forest Cancer Center | Truckee | California | 96161 | — |
| Kaiser Permanente Medical Center - Vallejo | Vallejo | California | 94589 | — |
| Kaiser Permanente Medical Center - Walnut Creek | Walnut Creek | California | 94596 | — |
| University of Colorado Cancer Center at UC Health Sciences Center | Aurora | Colorado | 80045 | — |
| Kaiser Permanente - Denver | Denver | Colorado | 80205 | — |
| Shaw Regional Cancer Center | Edwards | Colorado | 81632 | — |
| Valley View Hospital Cancer Center | Glenwood Springs | Colorado | 81601 | — |
| Kaiser Permanente - Lafayette | Lafayette | Colorado | 80026 | — |
| Montrose Memorial Hospital Cancer Center | Montrose | Colorado | 81401 | — |
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford | Connecticut | 06105 | — |
| Broward General Medical Center Cancer Center | Fort Lauderdale | Florida | 33316 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Northside Hospital Cancer Center | Atlanta | Georgia | 30342-1611 | — |
| Saint Joseph's Hospital of Atlanta | Atlanta | Georgia | 30342-1701 | — |
| CCOP - Atlanta Regional | Atlanta | Georgia | 30342 | — |
| WellStar Cobb Hospital | Austell | Georgia | 30106 | — |
| John B. Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Charles B. Eberhart Cancer Center at DeKalb Medical Center | Decatur | Georgia | 30033 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Gwinnett Medical Center | Lawrenceville | Georgia | 30045 | — |
| Kennestone Cancer Center at Wellstar Kennestone Hospital | Marietta | Georgia | 30060 | — |
| Southern Regional Medical Center | Riverdale | Georgia | 30274-2600 | — |
| Harbin Clinic Cancer Center - Medical Oncology | Rome | Georgia | 30165 | — |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Kaiser Permanente - Moanalua Medical Center and Clinic | Honolulu | Hawaii | 96819 | — |
| Cancer Care Center of Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Edward Hospital Cancer Center | Naperville | Illinois | 60540 | — |
| Central Dupage Cancer Center | Winfield | Illinois | 60190 | — |
| Cancer Center of Kansas, PA - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas, PA - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas, PA - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Cancer Center of Kansas, PA - Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas, PA - Liberal | Liberal | Kansas | 67905 | — |
| Cancer Center of Kansas, PA - Newton | Newton | Kansas | 67114 | — |
| Cancer Center of Kansas, PA - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas, PA - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas, PA - Salina | Salina | Kansas | 67401 | — |
| Tammy Walker Cancer Center at Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Cotton-O'Neil Cancer Center | Topeka | Kansas | 66606 | — |
| Cancer Center of Kansas, PA - Wellington | Wellington | Kansas | 67152 | — |
| Associates in Womens Health, PA - North Review | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas, PA - Wichita | Wichita | Kansas | 67214 | — |
| CCOP - Wichita | Wichita | Kansas | 67214 | — |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas, PA - Winfield | Winfield | Kansas | 67156 | — |
| Lucille P. Markey Cancer Center at University of Kentucky | Lexington | Kentucky | 40536-0093 | — |
| Boston University Cancer Research Center | Boston | Massachusetts | 02118 | — |
| Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | 48106-0995 | — |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48106 | — |
| Battle Creek Health System Cancer Care Center | Battle Creek | Michigan | 49017 | — |
| Mecosta County Medical Center | Big Rapids | Michigan | 49307 | — |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | 48123-2500 | — |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Butterworth Hospital at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| CCOP - Grand Rapids | Grand Rapids | Michigan | 49503 | — |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | 48236 | — |
| Foote Memorial Hospital | Jackson | Michigan | 49201 | — |
| Sparrow Regional Cancer Center | Lansing | Michigan | 48912-1811 | — |
| St. Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Mercy General Health Partners | Muskegon | Michigan | 49443 | — |
| St. Joseph Mercy Oakland | Pontiac | Michigan | 48341-2985 | — |
| Mercy Regional Cancer Center at Mercy Hospital | Port Huron | Michigan | 48060 | — |
| Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw | Michigan | 48601 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| St. John Macomb Hospital | Warren | Michigan | 48093 | — |
| Metro Health Hospital | Wyoming | Michigan | 49519 | — |
| Regional Cancer Center at Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| CCOP - Cancer Research for the Ozarks | Springfield | Missouri | 65802 | — |
| St. John's Regional Health Center | Springfield | Missouri | 65804 | — |
| Hulston Cancer Center at Cox Medical Center South | Springfield | Missouri | 65807 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies - Billings | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| St. Vincent Healthcare Cancer Care Services | Billings | Montana | 59101 | — |
| Billings Clinic - Downtown | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| St. James Healthcare Cancer Care | Butte | Montana | 59701 | — |
| Big Sky Oncology | Great Falls | Montana | 59405-5309 | — |
| Great Falls Clinic - Main Facility | Great Falls | Montana | 59405 | — |
| Sletten Cancer Institute at Benefis Healthcare | Great Falls | Montana | 59405 | — |
| Not listed | Great Falls | Montana | 59405 | — |
| Northern Montana Hospital | Havre | Montana | 59501 | — |
| St. Peter's Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology, PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Medical Oncology at KRMC | Kalispell | Montana | 59901 | — |
| Guardian Oncology and Center for Wellness | Missoula | Montana | 59804 | — |
| Montana Cancer Specialists at Montana Cancer Center | Missoula | Montana | 59807-7877 | — |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula | Montana | 59807 | — |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney | Nebraska | 68848-1990 | — |
| Highland Hospital of Rochester | Rochester | New York | 14620 | — |
| Interlakes Oncology/Hematology PC | Rochester | New York | 14623 | — |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Randolph Hospital | Asheboro | North Carolina | 27203-5400 | — |
| Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro | North Carolina | 27403-1198 | — |
| Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| Annie Penn Cancer Center | Reidsville | North Carolina | 27320 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Providence Milwaukie Hospital | Milwaukie | Oregon | 97222 | — |
| Providence Cancer Center at Providence Portland Medical Center | Portland | Oregon | 97213-2967 | — |
| Adventist Medical Center | Portland | Oregon | 97216 | — |
| CCOP - Columbia River Oncology Program | Portland | Oregon | 97225 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| St. Joseph Cancer Center | Bellingham | Washington | 98225 | — |
| Olympic Hematology and Oncology | Bremerton | Washington | 98310 | — |
| Columbia Basin Hematology | Kennewick | Washington | 99336 | — |
| Skagit Valley Hospital Cancer Care Center | Mount Vernon | Washington | 98273 | — |
| Harrison Poulsbo Hematology and Onocology | Poulsbo | Washington | 98370 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical, PLLC | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Group Health Central Hospital | Seattle | Washington | 98112 | — |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle | Washington | 98122-4307 | — |
| Polyclinic First Hill | Seattle | Washington | 98122 | — |
| University Cancer Center at University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology, PS | Spokane | Washington | 99218 | — |
| Southwest Washington Medical Center Cancer Center | Vancouver | Washington | 98668 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801-2028 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center at Sheridan Memorial Hospital | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00445848, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 5, 2020 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00445848 live on ClinicalTrials.gov.