Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure in Subjects at Increased Immunological Risk
Public ClinicalTrials.gov record NCT00447187. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Placebo-Controlled, Randomized, Parallel Group, Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure Following Penetrating Keratoplasty With LX201 Implantation in Subjects Who Are at Increased Immunological Risk
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a pivotal trial to determine whether LX201 reduces the likelihood of a graft rejection episode following corneal transplantation in patients at high immunological risk for rejection.
Study identification
- NCT ID
- NCT00447187
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 368 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2007 (Type not available)
- Primary completion
- Mar 2009 (Actual)
- Completion
- Nov 2010 (Actual)
- Last update posted
- Oct 11, 2012
2007 – 2010
United States locations
- U.S. sites
- 24
- U.S. states
- 18
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cornea Consultants of Arizona | Phoenix | Arizona | 85032 | — |
| Loma Linda University Health Care | Loma Linda | California | 92354 | — |
| USC Doheny Eye Institute | Los Angeles | California | 90033 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Emory Eye Center | Atlanta | Georgia | 30322 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Price Vision Group | Indianapolis | Indiana | 46260 | — |
| The Eye Center at Union Memorial Hospital | Baltimore | Maryland | 21218 | — |
| Wilmer Eye Institute, Cornea Service | Baltimore | Maryland | 21287 | — |
| New England Eye Center | Boston | Massachusetts | 02111 | — |
| W.K. Kellogg Eye Center - University of Michigan | Ann Arbor | Michigan | 48105 | — |
| MN Eye Consultants, P.A. | Bloomington | Minnesota | 55431 | — |
| Tauber Eye Center | Kansas City | Missouri | 64111 | — |
| Ophthalmology Associates | St Louis | Missouri | 63141 | — |
| UMDNJ - New Jersey Medical School Institute of Ophthalmology and Visual Science | Newark | New Jersey | 07103 | — |
| New York Eye and Ear Infirmary | New York | New York | 10003 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Ophthalmic Consultants of Long Island | Rockville Centre | New York | 11570 | — |
| Cornea Consultants of Albany | Slingerlands | New York | 12159 | — |
| Duke University Eye Center | Durham | North Carolina | 27705 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cornea Associates of Texas | Dallas | Texas | 75231 | — |
| Virginia Eye Consultants | Norfolk | Virginia | 23502 | — |
| Eye Associates NW | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00447187, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 11, 2012 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00447187 live on ClinicalTrials.gov.