Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Public ClinicalTrials.gov record NCT00447564. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Probuphine in Patients With Opioid Dependence
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low. Probuphine is an implant placed just beneath the skin that contains BPN. It is designed to provide 6 months of stable BPN blood levels. This study will test the safety and efficacy of Probuphine in the treatment of patients with opioid dependence.
Study identification
- NCT ID
- NCT00447564
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 163 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2006 (Type not available)
- Primary completion
- Jul 2008 (Actual)
- Completion
- Jul 2008 (Actual)
- Last update posted
- Dec 31, 2018
2006 – 2008
United States locations
- U.S. sites
- 18
- U.S. states
- 12
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90025 | — |
| Synergy Clinical Research Center | National City | California | 91950 | — |
| North County Clinical Research | Oceanside | California | 92056 | — |
| Amit Vijapura, MD and Associates | Jacksonville | Florida | 32256 | — |
| Fidelity Clinical Research | Lauderhill | Florida | 33319 | — |
| Scientific Clinical Research, Inc | North Miami | Florida | 33161 | — |
| Northwest Behavioral Research Center | Roswell | Georgia | 30076 | — |
| Behavioral Biology Research Unit, Johns Hopkins Bayview Campus | Baltimore | Maryland | 21224 | — |
| Dual Diagnosis Unit, SSTAR: Stanley Street Treatment and Resources, Inc. | Fall River | Massachusetts | 02720-6009 | — |
| Wayne State University Department of Psychiatry and Behavioral Neurosciences | Detroit | Michigan | 48207 | — |
| Psych Care Consultants Research | St Louis | Missouri | 63128 | — |
| New York VA Medical Center, NYU School of Medicine | New York | New York | 10010 | — |
| Addiction Institute of New York | New York | New York | 10019 | — |
| Duke University Medical Center Addictions Program | Durham | North Carolina | 27705 | — |
| Pahl Pharmaceutical Research, LLC | Oklahoma City | Oklahoma | 73118 | — |
| University of Pennsylvania Treatment Research Center | Philadelphia | Pennsylvania | 19104 | — |
| Providence Behavioral Health Services | Everett | Washington | 98206 | — |
| Puget Sound Health Care Systems | Seattle | Washington | 98108 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00447564, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 31, 2018 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00447564 live on ClinicalTrials.gov.