Evaluation of Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-threatening Influenza
Public ClinicalTrials.gov record NCT00453999. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase II, Multicenter, Randomized, Double-Mask, Double-Dummy Study Comparing Efficacy and Safety of Intravenous Peramivir Once Daily Versus Oral Oseltamivir Twice Daily in Adults With Acute Serious or Potentially Life-Threatening Influenza
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study has been designed as a randomized, double-blind, controlled, study to evaluate the efficacy and safety of two once daily intravenous peramivir regimens (200 mg and 400 mg) versus oral oseltamivir phosphate (75 mg twice daily) in hospitalized subjects with acute serious or potentially life threatening influenza. Study treatments will be provided for up to 5 consecutive days.
Study identification
- NCT ID
- NCT00453999
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 137 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2007
- Primary completion
- Aug 31, 2008
- Completion
- Jul 31, 2009
- Last update posted
- Feb 11, 2015
2007 – 2009
United States locations
- U.S. sites
- 41
- U.S. states
- 26
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pulmonary Associates of Mobile, P.C. | Mobile | Alabama | 36608 | — |
| St. Bernards Research Center/Clopton Clinic | Jonesboro | Arkansas | 72401 | — |
| Pulmonary Consultants & Primary Care Physicians Medical Group, Inc. | Orange | California | 92868 | — |
| University of California Irvine Medical Center | Orange | California | 92868 | — |
| University of California Davis Medical Center, Department of Emergency Medicine | Sacramento | California | 95817 | — |
| Good Samaritan Hospital | San Jose | California | 95124 | — |
| National Jewish Medical and Research Center, Clinical Research Unit | Denver | Colorado | 80206 | — |
| Orlando Regional Healthcare | Orlando | Florida | 32806 | — |
| James A. Haley Veterans Hospital, Department of Infectious Disease | Tampa | Florida | 33612 | — |
| Medical College of Georgia | Augusta | Georgia | 30912 | — |
| Infectious Disease Specialists of Atlanta, P.C. | Decatur | Georgia | 30033 | — |
| St. Joseph's/Candler Health System, Inc. | Savannah | Georgia | 31405 | — |
| Idaho Falls Infectious Diseases, PLLC | Idaho Falls | Idaho | 83404 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Springfield Clinic, LLP | Springfield | Illinois | 62701 | — |
| Wishard Hospital/Indiana University | Indianapolis | Indiana | 46202 | — |
| Infectious Disease of Indiana, PSC | Indianapolis | Indiana | 46280 | — |
| Natchitoches Internal Medicine | Natchitoches | Louisiana | 71457 | — |
| Louisiana State University Health Sciences Center-Shreveport | Shreveport | Louisiana | 71103 | — |
| VA Maryland Health Care System | Baltimore | Maryland | 21201 | — |
| Franklin Square Hospital | Baltimore | Maryland | 21237 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Wayne State University School of Medicine | Detroit | Michigan | 48201 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| William Beaumont Hospital Troy | Troy | Michigan | 48085 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Hackensack University Medical Center, Department of Infectious Disease | Hackensack | New Jersey | 07601 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07754 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131-0001 | — |
| Rochester General Hospital/University of Rochester | Rochester | New York | 14621-3001 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106-5083 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Lowcountry Infectious Diseases, P.A. | Charleston | South Carolina | 29414 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84132 | — |
| Veterans Affairs Medical Center | Salem | Virginia | 24153 | — |
| Franciscan Health System | Tacoma | Washington | 98405 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449-5703 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226-3522 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 42 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00453999, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 11, 2015 · Synced Sep 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00453999 live on ClinicalTrials.gov.