ClinicalTrials.gov record
Pemetrexed Disodium With or Without Sorafenib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
ClinicalTrials.gov ID: NCT00454194
Public ClinicalTrials.gov record NCT00454194. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase II Randomized Study of Pemetrexed With Sorafenib Versus Pemetrexed Alone as Second-Line Therapy in Patients With Advanced Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Pemetrexed disodium and sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving pemetrexed disodium together with sorafenib may kill more tumor cells. PURPOSE: This randomized phase II trial is studying pemetrexed disodium and sorafenib to see how well they work compared with pemetrexed disodium alone as second-line therapy in treating patients with stage IIIB or stage IV non-small cell lung cancer.
Study identification
- NCT ID
- NCT00454194
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 110 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2007 (Type not available)
- Primary completion
- Jul 2010 (Actual)
- Completion
- May 2013 (Actual)
- Last update posted
- Mar 21, 2017
2007 – 2013
United States locations
- U.S. sites
- 207
- U.S. states
- 20
- U.S. cities
- 127
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Scottsdale | Scottsdale | Arizona | 85259-5499 | — |
| Aurora Presbyterian Hospital | Aurora | Colorado | 80012 | — |
| Boulder Community Hospital | Boulder | Colorado | 80301-9019 | — |
| Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | 80933 | — |
| St. Anthony Central Hospital | Denver | Colorado | 80204 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| Presbyterian - St. Luke's Medical Center | Denver | Colorado | 80218 | — |
| St. Joseph Hospital | Denver | Colorado | 80218 | — |
| Rose Medical Center | Denver | Colorado | 80220 | — |
| CCOP - Colorado Cancer Research Program | Denver | Colorado | 80224-2522 | — |
| Swedish Medical Center | Englewood | Colorado | 80110 | — |
| St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction | Colorado | 81502 | — |
| North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| Hope Cancer Care Center at Longmont United Hospital | Longmont | Colorado | 80501 | — |
| McKee Medical Center | Loveland | Colorado | 80539 | — |
| St. Mary - Corwin Regional Medical Center | Pueblo | Colorado | 81004 | — |
| North Suburban Medical Center | Thornton | Colorado | 80229 | — |
| Exempla Lutheran Medical Center | Wheat Ridge | Colorado | 80033 | — |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | — |
| Rush-Copley Cancer Care Center | Aurora | Illinois | 60504 | — |
| Illinois CancerCare - Bloomington | Bloomington | Illinois | 61701 | — |
| St. Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital | Canton | Illinois | 61520 | — |
| Illinois CancerCare - Canton | Canton | Illinois | 61520 | — |
| Illinois CancerCare - Carthage | Carthage | Illinois | 62321 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| Eureka Community Hospital | Eureka | Illinois | 61530 | — |
| Illinois CancerCare - Eureka | Eureka | Illinois | 61530 | — |
| Galesburg Clinic, PC | Galesburg | Illinois | 61401 | — |
| Galesburg Cottage Hospital | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare - Galesburg | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare - Havana | Havana | Illinois | 62644 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Illinois CancerCare - Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| Illinois CancerCare - Macomb | Macomb | Illinois | 61455 | — |
| McDonough District Hospital | Macomb | Illinois | 61455 | — |
| Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline | Illinois | 61265 | — |
| Not listed | Moline | Illinois | 61265 | — |
| Illinois CancerCare - Monmouth | Monmouth | Illinois | 61462 | — |
| OSF Holy Family Medical Center | Monmouth | Illinois | 61462 | — |
| BroMenn Regional Medical Center | Normal | Illinois | 61761 | — |
| Community Cancer Center | Normal | Illinois | 61761 | — |
| Illinois CancerCare - Community Cancer Center | Normal | Illinois | 61761 | — |
| Community Hospital of Ottawa | Ottawa | Illinois | 61350 | — |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa | Illinois | 61350 | — |
| Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | 61554 | — |
| Illinois CancerCare - Pekin | Pekin | Illinois | 61603 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61615 | — |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF St. Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois CancerCare - Peru | Peru | Illinois | 61354 | — |
| Illinois Valley Community Hospital | Peru | Illinois | 61354 | — |
| Illinois CancerCare - Princeton | Princeton | Illinois | 61356 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| Illinois CancerCare - Spring Valley | Spring Valley | Illinois | 61362 | — |
| Carle Cancer Center at Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove | Indiana | 46107 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46515 | — |
| Howard Community Hospital | Kokomo | Indiana | 46904 | — |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | 46350 | — |
| Saint Anthony Memorial Health Centers | Michigan City | Indiana | 46360 | — |
| Reid Hospital & Health Care Services | Richmond | Indiana | 47374 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Saint Joseph Regional Medical Center | South Bend | Indiana | 46617 | — |
| South Bend Clinic | South Bend | Indiana | 46617 | — |
| McFarland Clinic, PC | Ames | Iowa | 50010 | — |
| Not listed | Bettendorf | Iowa | 52722 | — |
| Cedar Rapids Oncology Associates | Cedar Rapids | Iowa | 52403 | — |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | — |
| Medical Oncology and Hematology Associates - West Des Moines | Clive | Iowa | 50325 | — |
| Mercy Capitol Hospital | Des Moines | Iowa | 50307 | — |
| CCOP - Iowa Oncology Research Association | Des Moines | Iowa | 50309 | — |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | 50314 | — |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines | Iowa | 50316 | — |
| Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City | Iowa | 50401 | — |
| McCreery Cancer Center at Ottumwa Regional | Ottumwa | Iowa | 52501 | — |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | 51101 | — |
| Mercy Medical Center - Sioux City | Sioux City | Iowa | 51104 | — |
| St. Luke's Regional Medical Center | Sioux City | Iowa | 51104 | — |
| Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | 48106-0995 | — |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48106 | — |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | 48123-2500 | — |
| Green Bay Oncology, Limited - Escanaba | Escanaba | Michigan | 49431 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | 48236 | — |
| Dickinson County Healthcare System | Iron Mountain | Michigan | 49801 | — |
| Foote Memorial Hospital | Jackson | Michigan | 49201 | — |
| Sparrow Regional Cancer Center | Lansing | Michigan | 48912-1811 | — |
| St. Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| St. Joseph Mercy Oakland | Pontiac | Michigan | 48341-2985 | — |
| Mercy Regional Cancer Center at Mercy Hospital | Port Huron | Michigan | 48060 | — |
| Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw | Michigan | 48601 | — |
| Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| St. John Macomb Hospital | Warren | Michigan | 48093 | — |
| MeritCare Bemidji | Bemidji | Minnesota | 56601 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Duluth Clinic Cancer Center - Duluth | Duluth | Minnesota | 55805-1983 | — |
| CCOP - Duluth | Duluth | Minnesota | 55805 | — |
| Miller - Dwan Medical Center | Duluth | Minnesota | 55805 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Fergus Falls Medical Group, PA | Fergus Falls | Minnesota | 56537 | — |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley | Minnesota | 55432 | — |
| Hutchinson Area Health Care | Hutchinson | Minnesota | 55350 | — |
| HealthEast Cancer Care at St. John's Hospital | Maplewood | Minnesota | 55109 | — |
| Minnesota Oncology Hematology, PA - Maplewood | Maplewood | Minnesota | 55109 | — |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | 55415 | — |
| Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | 55422-2900 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Cancer Center | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital Cancer Care Center | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee | Minnesota | 55379 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Willmar Cancer Center at Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology Hematology, PA - Woodbury | Woodbury | Minnesota | 55125 | — |
| Missouri Baptist Cancer Center | St Louis | Missouri | 63131 | — |
| Arch Medical Services, Incorporated at Center for Cancer Care and Research | St Louis | Missouri | 63141 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies - Billings | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| St. Vincent Healthcare Cancer Care Services | Billings | Montana | 59101 | — |
| Billings Clinic - Downtown | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| St. James Healthcare Cancer Care | Butte | Montana | 59701 | — |
| Big Sky Oncology | Great Falls | Montana | 59405-5309 | — |
| Great Falls Clinic - Main Facility | Great Falls | Montana | 59405 | — |
| Sletten Cancer Institute at Benefis Healthcare | Great Falls | Montana | 59405 | — |
| Not listed | Great Falls | Montana | 59405 | — |
| Northern Montana Hospital | Havre | Montana | 59501 | — |
| St. Peter's Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology, PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Medical Oncology at KRMC | Kalispell | Montana | 59901 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Center | Missoula | Montana | 59801 | — |
| Guardian Oncology and Center for Wellness | Missoula | Montana | 59804 | — |
| Montana Cancer Specialists at Montana Cancer Center | Missoula | Montana | 59807-7877 | — |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula | Montana | 59807 | — |
| CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| Immanuel Medical Center | Omaha | Nebraska | 68122 | — |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha | Nebraska | 68124 | — |
| Creighton University Medical Center | Omaha | Nebraska | 68131-2197 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Bismarck Cancer Center | Bismarck | North Dakota | 58501 | — |
| Medcenter One Hospital Cancer Care Center | Bismarck | North Dakota | 58501 | — |
| Mid Dakota Clinic, PC | Bismarck | North Dakota | 58501 | — |
| St. Alexius Medical Center Cancer Center | Bismarck | North Dakota | 58502 | — |
| CCOP - MeritCare Hospital | Fargo | North Dakota | 58122 | — |
| MeritCare Broadway | Fargo | North Dakota | 58122 | — |
| Altru Cancer Center at Altru Hospital | Grand Forks | North Dakota | 58201 | — |
| Mary Rutan Hospital | Bellefontaine | Ohio | 43311 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Riverside Methodist Hospital Cancer Care | Columbus | Ohio | 43214-3998 | — |
| CCOP - Columbus | Columbus | Ohio | 43215 | — |
| Grant Medical Center Cancer Care | Columbus | Ohio | 43215 | — |
| Mount Carmel Health - West Hospital | Columbus | Ohio | 43222 | — |
| Doctors Hospital at Ohio Health | Columbus | Ohio | 43228 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital | Dayton | Ohio | 45406 | — |
| David L. Rike Cancer Center at Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Cancer Care Center | Dayton | Ohio | 45415 | — |
| CCOP - Dayton | Dayton | Ohio | 45420 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Blanchard Valley Medical Associates | Findlay | Ohio | 45840 | — |
| Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Charles F. Kettering Memorial Hospital | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Strecker Cancer Center at Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Mercy Medical Center | Springfield | Ohio | 45504 | — |
| Community Hospital of Springfield and Clark County | Springfield | Ohio | 45505 | — |
| UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | 45373-1300 | — |
| Mount Carmel St. Ann's Cancer Center | Westerville | Ohio | 43081 | — |
| Clinton Memorial Hospital | Wilmington | Ohio | 45177 | — |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Genesis - Good Samaritan Hospital | Zanesville | Ohio | 43701 | — |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | 74136 | — |
| Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown | Pennsylvania | 18105 | — |
| AnMed Cancer Center | Anderson | South Carolina | 29621 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29303 | — |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Medical X-Ray Center, PC | Sioux Falls | South Dakota | 57105 | — |
| Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls | South Dakota | 57117-5039 | — |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | 54301-3526 | — |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | 54303 | — |
| St. Mary's Hospital Medical Center - Green Bay | Green Bay | Wisconsin | 54303 | — |
| St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | 54307-3508 | — |
| Franciscan Skemp Healthcare - La Crosse Campus | La Crosse | Wisconsin | 54601 | — |
| Holy Family Memorial Medical Center Cancer Care Center | Manitowoc | Wisconsin | 54221-1450 | — |
| Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Green Bay Oncology, Limited - Oconto Falls | Oconto Falls | Wisconsin | 54154 | — |
| Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay | Wisconsin | 54235 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center at Sheridan Memorial Hospital | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00454194, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 21, 2017 · Synced Nov 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00454194 live on ClinicalTrials.gov.