A Study of Mircera in Hemoglobin Control of Patients Transitioning to Dialysis.
Public ClinicalTrials.gov record NCT00454246. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open Label Study of the Effect of Intravenous Mircera on Hemoglobin Control in Patients Transitioning From Chronic Kidney Disease Stage 4 Through Dialysis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the efficacy and safety of methoxy polyethylene glycol-epoetin beta (Mircera) in the maintenance of hemoglobin levels in patients who have previously received treatment with epoetin alfa or darbepoetin alfa, and who are transitioning from chronic kidney disease stage 4 through dialysis. Patients will be randomized either to receive Mircera or to remain on their existing therapy; the initial monthly dose of subcutaneous (sc) Mircera (120-360 micrograms) will be based on the average weekly dose of epoetin alfa or darbepoetin alfa administered in the week preceding the switch to Mircera. At the initiation of dialysis, patients in the Mircera group will receive monthly intravenous (iv) Mircera at a starting dose based on their previous (sc) dose, and those in the control group will receive weekly (iv) epoetin alfa. The anticipated time on study treatment is 1-2 years, and the target sample size is 500+ individuals.
Study identification
- NCT ID
- NCT00454246
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 111 participants
Conditions and interventions
Conditions
Interventions
- methoxy polyethylene glycol-epoetin beta Drug
- epoetin alfa Drug
- darbepoetin alfa Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2007 (Type not available)
- Primary completion
- Feb 2008 (Actual)
- Completion
- Feb 2008 (Actual)
- Last update posted
- Dec 16, 2011
2007 – 2008
United States locations
- U.S. sites
- 78
- U.S. states
- 32
- U.S. cities
- 78
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Birmingham | Alabama | — | — |
| Not listed | Mobile | Alabama | — | — |
| Not listed | Phoenix | Arizona | — | — |
| Not listed | El Dorado | Arkansas | — | — |
| Not listed | Hot Springs | Arkansas | — | — |
| Not listed | Bakersfield | California | — | — |
| Not listed | Glendale | California | — | — |
| Not listed | Granada Hills | California | 91344 | — |
| Not listed | Los Angeles | California | — | — |
| Not listed | Orange | California | — | — |
| Not listed | Palm Springs | California | — | — |
| Not listed | Riverside | California | — | — |
| Not listed | San Diego | California | — | — |
| Not listed | Yuba City | California | — | — |
| Not listed | Colorado Springs | Colorado | — | — |
| Not listed | Lakewood | Colorado | — | — |
| Not listed | Stamford | Connecticut | — | — |
| Not listed | Miami | Florida | — | — |
| Not listed | Ocala | Florida | — | — |
| Not listed | Orlando | Florida | — | — |
| Not listed | Palm Beach Gardens | Florida | — | — |
| Not listed | Pembroke Pines | Florida | — | — |
| Not listed | Tampa | Florida | — | — |
| Not listed | Atlanta | Georgia | — | — |
| Not listed | Augusta | Georgia | — | — |
| Not listed | Macon | Georgia | — | — |
| Not listed | Meridan | Idaho | 83642 | — |
| Not listed | Evergreen Park | Illinois | — | — |
| Not listed | Fort Wayne | Indiana | — | — |
| Not listed | Wichita | Kansas | — | — |
| Not listed | Baton Rouge | Louisiana | — | — |
| Not listed | Shreveport | Louisiana | — | — |
| Not listed | Germantown | Maryland | — | — |
| Not listed | Boston | Massachusetts | — | — |
| Not listed | Springfield | Massachusetts | — | — |
| Not listed | Detroit | Michigan | — | — |
| Not listed | Milwaukee | Michigan | — | — |
| Not listed | Royal Oak | Michigan | — | — |
| Not listed | Columbus | Mississippi | — | — |
| Not listed | St Louis | Missouri | — | — |
| Not listed | Omaha | Nebraska | — | — |
| Not listed | Voorhees Township | New Jersey | — | — |
| Not listed | West Orange | New Jersey | 07052 | — |
| Not listed | Brooklyn | New York | — | — |
| Not listed | Buffalo | New York | — | — |
| Not listed | Flushing | New York | — | — |
| Not listed | Great Neck | New York | — | — |
| Not listed | Mineola | New York | — | — |
| Not listed | Springfield Gardens | New York | — | — |
| Not listed | Syracuse | New York | — | — |
| Not listed | The Bronx | New York | — | — |
| Not listed | Durham | North Carolina | — | — |
| Not listed | Greenville | North Carolina | — | — |
| Not listed | Raleigh | North Carolina | — | — |
| Not listed | Winston-Salem | North Carolina | — | — |
| Not listed | Maimisburg | Ohio | — | — |
| Not listed | Toledo | Ohio | — | — |
| Not listed | Portland | Oregon | — | — |
| Not listed | Erie | Pennsylvania | — | — |
| Not listed | Lewistown | Pennsylvania | — | — |
| Not listed | Philadelphia | Pennsylvania | — | — |
| Not listed | Pittsburgh | Pennsylvania | — | — |
| Not listed | Providence | Rhode Island | — | — |
| Not listed | Columbia | South Carolina | — | — |
| Not listed | Greenville | South Carolina | — | — |
| Not listed | Orangeburg | South Carolina | — | — |
| Not listed | Chattanooga | Tennessee | — | — |
| Not listed | Dyersburg | Tennessee | — | — |
| Not listed | Houston | Texas | 77024 | — |
| Not listed | San Antonio | Texas | — | — |
| Not listed | Temple | Texas | — | — |
| Not listed | Alexandria | Virginia | — | — |
| Not listed | Fairfax | Virginia | — | — |
| Not listed | Richmond | Virginia | — | — |
| Not listed | Salem | Virginia | — | — |
| Not listed | Bluefield | West Virginia | — | — |
| Not listed | Morgantown | West Virginia | — | — |
| Not listed | Appleton | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00454246, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 16, 2011 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00454246 live on ClinicalTrials.gov.