Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE)
Public ClinicalTrials.gov record NCT00456508. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Open-label Patient Continuation of DX-88 (Ecallantide) for Acute Hereditary Angioedema Attacks
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of repeated doses of ecallantide in the treatment of acute attacks of hereditary angioedema and to allow HAE patients continued access to ecallantide. In addition, patients enrolled in DX-88/20 (EDEMA4) trial will be followed up and treated for subsequent attacks in this trial.
Study identification
- NCT ID
- NCT00456508
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 147 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 10 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 1, 2007 (Actual)
- Primary completion
- Jun 1, 2010 (Actual)
- Completion
- Sep 1, 2010 (Actual)
- Last update posted
- Jun 8, 2021
2007 – 2010
United States locations
- U.S. sites
- 39
- U.S. states
- 26
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Aaron Davis | Scottsdale | Arizona | 85251 | — |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | — |
| Little Rock Allergy & Asthma Clinic | Little Rock | Arkansas | 72205 | — |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley | California | 94704 | — |
| Pacific Coast Allergy | Crescent City | California | 95531 | — |
| Jacob Offenberger | Granada Hills | California | 91344 | — |
| UCLA David Geffen School of Medicine, Department of Medicine | Los Angeles | California | 90095-1680 | — |
| Asthma and Allergy Associates, P.C. | Colorado Springs | Colorado | 80907 | — |
| Christiana Hospital, Christiana Care Health Services | Newark | Delaware | 19718 | — |
| Georgetown University Medical Center, Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| University of Miami, General Clinical Research Center | Miami | Florida | 33136 | — |
| University of South Florida, Asthma, Allergy and Immunology Clinical Research Unit | Tampa | Florida | 33613 | — |
| Roberson Allergy and Asthma | West Palm Beach | Florida | 33401 | — |
| Family Allergy & Asthma Center, PC | Atlanta | Georgia | 30342 | — |
| Allergy Center of Brookstone | Columbus | Georgia | 31904 | — |
| University Consultants in Allergy and Immunology | Chicago | Illinois | 60612 | — |
| Muncie Allergy Center | Muncie | Indiana | 47304 | — |
| Kansas City Allergy & Asthma | Overland Park | Kansas | 66210 | — |
| Institute for Asthma and Allergy | Wheaton | Maryland | 20902 | — |
| Brigham and Women's Hospital | Chestnut Hill | Massachusetts | 02467 | — |
| Asthma and Allergy Institutes of Michigan | Clinton Township | Michigan | 48038 | — |
| Respiratory Medicine Research Institute of Michigan, PLC | Ypsilanti | Michigan | 48197 | — |
| Nevada Access to Research and Education Society | Las Vegas | Nevada | 89102 | — |
| University of Nevada School of Medicine | Reno | Nevada | 89503 | — |
| UMDNJ- New Jersey Medical School | Newark | New Jersey | 07103 | — |
| Allergy Partners of Albuquerque | Albuquerque | New Mexico | 87109 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| Allergy Partners of Western North Carolina | Asheville | North Carolina | 28801 | — |
| University of Cincinnati, Division of Internal Medicine | Cincinnati | Ohio | 45267 | — |
| Optimed Research, LLC | Columbus | Ohio | 43235 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Asthma Allergy and Pulmonary Associates | Philadelphia | Pennsylvania | 19107 | — |
| Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Highlands Allergy and Asthma Center, PC | Bristol | Tennessee | 37620 | — |
| The Paull Allergy and Asthma Clinic, P.A | Bryan | Texas | 77802 | — |
| AARA Research Center | Dallas | Texas | 75231 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84132-2409 | — |
| Clinical Research Associates of Tidewater | Norfolk | Virginia | 23507 | — |
| Puget Sound Allergy, Asthma, & Immunology | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00456508, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 8, 2021 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00456508 live on ClinicalTrials.gov.