Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)
Public ClinicalTrials.gov record NCT00457015. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EDEMA4: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess the Efficacy and Safety of DX-88 (Ecallantide) for the Treatment of Acute Attacks of Hereditary Angioedema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of DX-88 (ecallantide) versus placebo in the treatment of moderate to severe acute attacks of hereditary angioedema.
Study identification
- NCT ID
- NCT00457015
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 96 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 10 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 1, 2007 (Actual)
- Primary completion
- Jun 1, 2008 (Actual)
- Completion
- Jun 1, 2008 (Actual)
- Last update posted
- Jun 8, 2021
2007 – 2008
United States locations
- U.S. sites
- 42
- U.S. states
- 26
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Aaron J. Davis | Scottsdale | Arizona | 85251 | — |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | — |
| Little Rock Allergy & Asthma Clinic | Little Rock | Arkansas | 72205 | — |
| Alta Bates Comprehensive Cancer Center | Berkeley | California | 94704 | — |
| Pacific Coast Allergy | Crescent City | California | 95531 | — |
| Jacob Offenberger | Granada Hills | California | 91344 | — |
| UCLA David Geffen School of Medicine, Department of Medicine | Los Angeles | California | 90095-1680 | — |
| Asthma and Allergy Associates, P.C. | Colorado Springs | Colorado | 80907 | — |
| Christiana Hospital | Newark | Delaware | 19718 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| University of Miami, General Clinical Research Center | Miami | Florida | 33136 | — |
| University of South Florida | Tampa | Florida | 33613 | — |
| Roberson Allergy and Asthma | West Palm Beach | Florida | 33401 | — |
| Family Allergy & Asthma Center, PC | Atlanta | Georgia | 30342 | — |
| Allergy Center of Brookstone | Columbus | Georgia | 31904 | — |
| University Consultants in Allergy and Immunology | Chicago | Illinois | 60612 | — |
| Muncie Allergy Center | Muncie | Indiana | 47304 | — |
| Kansas City Allergy & Asthma | Overland Park | Kansas | 66210 | — |
| Institute for Asthma and Allergy | Wheaton | Maryland | 20902 | — |
| Brigham and Women's Hospital | Chestnut Hill | Massachusetts | 02467 | — |
| Asthma and Allergy Institute of Michigan | Clinton Township | Michigan | 48038 | — |
| Respiratory Medicine Research Institute of Michigan, PLC | Ypsilanti | Michigan | 48197 | — |
| Nevada Access to Research and Education Society | Las Vegas | Nevada | 89102 | — |
| University of Nevada School of Medicine | Reno | Nevada | 89503 | — |
| UMDNJ-New Jersey Medical School | Newark | New Jersey | 07103 | — |
| Allergy Partners of Albuquerque | Albuquerque | New Mexico | 87109 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| Allergy Partners of Western North Carolina | Asheville | North Carolina | 28801 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Optimed Research, LLC | Columbus | Ohio | 43235 | — |
| Valley Clinical Research Center | Easton | Pennsylvania | 18045 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Asthma Allergy and Pulmonary Associates | Philadelphia | Pennsylvania | 19107 | — |
| Childrens Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Highlands Allergy and Asthma Center, PC | Bristol | Tennessee | 37620 | — |
| The Paull Allergy and Asthma Clinic, P.A. | Bryan | Texas | 77802 | — |
| AARA Research Center | Dallas | Texas | 75231 | — |
| University of Texas Medical School | Galveston | Texas | 77555-1083 | — |
| Baylor Clinic, Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132-2409 | — |
| Clinical Research Associates of Tidewater | Norfolk | Virginia | 23507 | — |
| Puget Sound Allergy, Asthma, & Immunology | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00457015, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 8, 2021 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00457015 live on ClinicalTrials.gov.