Patent Foramen Ovale Closure or Medical Therapy After Stroke - RESPECT Trial
Public ClinicalTrials.gov record NCT00465270. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment (RESPECT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to investigate whether percutaneous Patent Foramen Ovale (PFO) closure, using the AMPLATZER PFO Occluder, is superior to current standard of care medical treatment in the prevention of recurrent embolic stroke.
Study identification
- NCT ID
- NCT00465270
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 980 participants
Conditions and interventions
Conditions
Interventions
Device · Other
Eligibility (public fields only)
- Age range
- 18 Years to 60 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2003 (Actual)
- Primary completion
- May 2012 (Actual)
- Completion
- May 2016 (Actual)
- Last update posted
- Feb 18, 2019
2003 – 2016
United States locations
- U.S. sites
- 61
- U.S. states
- 32
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35249 | — |
| Mayo Clinic | Scottsdale | Arizona | 85259 | — |
| LAC + USC Medical Center | Los Angeles | California | 90033 | — |
| UCLA | Los Angeles | California | 90095 | — |
| Summit Medical Center | Oakland | California | 94609 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Kaiser Permanente | San Francisco | California | 94115 | — |
| University of Colorado | Denver | Colorado | 80262 | — |
| South Denver Cardiology Associates | Littleton | Colorado | 80120 | — |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| George Washington University Hospital | Washington D.C. | District of Columbia | 20037 | — |
| St. Vincent's Medical Center | Jacksonville | Florida | 32204 | — |
| Northwestern University | Chicago | Illinois | 60611-3078 | — |
| University of Chicago | Chicago | Illinois | 60637-1470 | — |
| Neurologic Associates Inc | Palos Heights | Illinois | 60463 | — |
| OSF St. Francis Medical Center | Peoria | Illinois | 61637 | — |
| Southern Illinois University Neurology | Springfield | Illinois | 62702 | — |
| Indiana Heart Physicians | Indianapolis | Indiana | 46237 | — |
| Ruan Neurology | Des Moines | Iowa | 50314 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Kansas University Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Midatlantic Cardiovascular Associates | Towson | Maryland | 21014 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109-0316 | — |
| St. Mary's Duluth Clinic | Duluth | Minnesota | 55805 | — |
| Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Methodist Hospital/Park Nicollet Medical Center | Saint Louis Park | Minnesota | 55426 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-2045 | — |
| Our Lady of Lourdes Medical Center | Cherry Hill | New Jersey | 08034 | — |
| University of Medicine and Dentistry of New Jersy | Newark | New Jersey | 07103 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| DENT Neurologic Institute | Amherst | New York | 14226 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Moses H. Cone Memorial Hospital | Greensboro | North Carolina | 27410 | — |
| Neurology and Neuroscience Associates | Akron | Ohio | 44320 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Providence St. Vincent's Medical Center | Portland | Oregon | 97225 | — |
| Oregon Stroke Center, OHSU | Portland | Oregon | 97329 | — |
| LeHigh Valley Hospital | Allentown | Pennsylvania | 18105 | — |
| Penn State Milton South Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17543 | — |
| St. Mary's Medical Center | Langhorne | Pennsylvania | 19067 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| North Central Heart Institute | Sioux Falls | South Dakota | 57108 | — |
| St. Thomas Neurology | Nashville | Tennessee | 37205 | — |
| Vanderbilt University | Nashville | Tennessee | 37232-8802 | — |
| UT Southwestern Medical School | Dallas | Texas | 75390-8897 | — |
| University of Texas Houston Health Science Center | Houston | Texas | 77030 | — |
| Sentara Virginia Beach General Hospital | Virginia Beach | Virginia | 23454 | — |
| UW Medicine Stroke Center | Seattle | Washington | 98104 | — |
| Charleston Area Medical Center | Charleston | West Virginia | 25304 | — |
| University of Wisconsin Hospital | Madison | Wisconsin | 53792 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00465270, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 18, 2019 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00465270 live on ClinicalTrials.gov.