ClinicalTrials.gov record
A Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Protopic for the Treatment of Atopic Dermatitis
ClinicalTrials.gov ID: NCT00475605
Public ClinicalTrials.gov record NCT00475605. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
APPLES: A Prospective Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Tacrolimus Ointment for the Treatment of Atopic Dermatitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an observational study to assess the long-term safety of Protopic® Ointment for the treatment of atopic dermatitis. Patients whose ages are/were \< 16 years at the time of first tacrolimus ointment exposure are eligible to participate. No drug is distributed during this observational trial.
Study identification
- NCT ID
- NCT00475605
- Recruitment status
- Terminated
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 8,071 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- Up to 16 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 24, 2005
- Primary completion
- Jan 30, 2019
- Completion
- Jan 30, 2019
- Last update posted
- Dec 17, 2019
2005 – 2019
United States locations
- U.S. sites
- 198
- U.S. states
- 42
- U.S. cities
- 158
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Shelby Dermatology | Alabaster | Alabama | 35007 | — |
| Pediatric Care Center of NE Alabama | Anniston | Alabama | 36207 | — |
| Total Skin and Beauty Dermatology Center | Birmingham | Alabama | 35205 | — |
| Metro Pediatrics, P.C | Birmingham | Alabama | 35209 | — |
| Pediatric & Adult Asthma and Allergy, P.C. | Birmingham | Alabama | 35209 | — |
| Skin Wellness Center of Alabama | Birmingham | Alabama | 35209 | — |
| Southview Dermatology | Birmingham | Alabama | 35213 | — |
| Ruth A Yates | Huntsville | Alabama | 35801 | — |
| Alliance Dermatology | Phoenix | Arizona | 85032 | — |
| Derma | Phoenix | Arizona | 85048 | — |
| Burke Pharmaceutical Research | Hot Springs | Arkansas | 71913 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Hull Dermatology, P.A. | Rogers | Arkansas | 72758 | — |
| Coastal Allergy Care | Camarillo | California | 93010 | — |
| Tien Nguyen | Fountain Valley | California | 92708 | — |
| Dermatology Research Associates | Los Angeles | California | 90045 | — |
| California Skin Institute | Mountain View | California | 94040 | — |
| Capital Allergy & Respiratory Disease Center | Roseville | California | 95661 | — |
| Allergy and Immunology Clinic | San Diego | California | 92111 | — |
| Rady Children's Hospital San Diego | San Diego | California | 92123 | — |
| California Dermatology Care | San Ramon | California | 94583 | — |
| Connecticut Children's Medical Center Dept of Dermatology | Hartford | Connecticut | 06106 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06519 | — |
| Webster Dermatology, PA | Hockessin | Delaware | 19707 | — |
| Atlantic Skin & Cosmetic Surgery Group | Wilmington | Delaware | 19810 | — |
| Center for Dermatology | Boca Raton | Florida | 33428 | — |
| Angelos Koutsonikolis, MD, PA | Boynton Beach | Florida | 33437 | — |
| Joshua Berlin P.A. | Boynton Beach | Florida | 33437 | — |
| Fort Lauderdale Dermatology & Cosmetic Skin Center | Fort Lauderdale | Florida | 33308 | — |
| North Florida Dermatology Associates, P.A. | Jacksonville | Florida | 32204 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Andrea Trowers, MD | North Miami | Florida | 33181 | — |
| Tory Patrick Sullivan | North Miami Beach | Florida | 33162 | — |
| Allergy Associates of the Palm Beaches, PA | North Palm Beach | Florida | 33408 | — |
| Orlando Dermatology | Orlando | Florida | 32819 | — |
| Donna Zeide | Palm Beach Gardens | Florida | 33418 | — |
| Waterman Dermatology | Plantation | Florida | 33324 | — |
| Olympian Clinical Research | Tampa | Florida | 33615 | — |
| Dr.Robert A. Norman | Tampa | Florida | 33626 | — |
| Georgia Pollens Clinical Research Centers, Inc | Albany | Georgia | 31707 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Dermatology Consultants PC | Covington | Georgia | 30014 | — |
| Dermatologic Surgery Specialist Inc. | Macon | Georgia | 31217 | — |
| MedaPhase,Inc. | Newnan | Georgia | 30263 | — |
| AeroAllergy Research Labs of Savannah, Inc. | Savannah | Georgia | 31406 | — |
| Southern Crescent Dermatology | Stockbridge | Georgia | 30281 | — |
| Paul S. Takiguchi- MD- Inc. | ‘Aiea | Hawaii | 96701 | — |
| Wayne Fujita, M.D. - Private Practice | ‘Aiea | Hawaii | 96701 | — |
| Dermatology Clinic of Idaho | Boise | Idaho | 83704 | — |
| Southeast Idaho Family Practice | Idaho Falls | Idaho | 83404 | — |
| DermAssociates LTD | Belleville | Illinois | 62226 | — |
| Christie Clinic | Champaign | Illinois | 61820 | — |
| Children's Memorial Hospital | Chicago | Illinois | 60614 | — |
| Dermatology, Inc. | Carmel | Indiana | 46032 | — |
| Shideler Clinical Research Center | Carmel | Indiana | 46032 | — |
| Dermatology Associates, PC | Indianapolis | Indiana | 46240 | — |
| Dawes Fretzin Clinical Research Group, LLC | Indianapolis | Indiana | 46256 | — |
| The Dermatology Center | New Albany | Indiana | 47150 | — |
| Dermatology Center of Indiana P.C. | Plainfield | Indiana | 46168 | — |
| Randall Dermatology | West Lafayette | Indiana | 47906 | — |
| Clinton Urgent Care | Clinton | Iowa | 52732 | — |
| Midwest Dermatology | Overland Park | Kansas | 66209 | — |
| Kansas City Dermatology, PA | Overland Park | Kansas | 66215 | — |
| Kansas Medical Clinic, PA | Topeka | Kansas | 66614 | — |
| Mid-Kansas Dermatology Clinic, PA | Wichita | Kansas | 67206 | — |
| Melissa Knuckles | Corbin | Kentucky | 40701 | — |
| Michael W. Simon, M.D. | Nicholasville | Kentucky | 40356 | — |
| LA Dermatology Assoc LLC | Baton Rouge | Louisiana | 70809 | — |
| Kids First Prytania | New Orleans | Louisiana | 70115 | — |
| All Kids Pediatrics of Opelousas APMC | Opelousas | Louisiana | 70570 | — |
| Holliway Pediatric Clinic | Shreveport | Louisiana | 71103 | — |
| Highland Clinic | Shreveport | Louisiana | 71105 | — |
| Wee Care Pediatrics & Kidmed Clinic | Shreveport | Louisiana | 71107 | — |
| Healing Hands Family Medicine | Shreveport | Louisiana | 71129 | — |
| Dimitri Dermatology | Slidell | Louisiana | 70458 | — |
| Johns Hopkins University, Division of Pediatric Dermatolgy | Baltimore | Maryland | 21287 | — |
| Clarksburg Pediatrics, LLC | Clarksburg | Maryland | 20871 | — |
| Family Allergy & Asthma Care | Gaithersburg | Maryland | 20878 | — |
| Callender Skin and Laser Center | Glenn Dale | Maryland | 20769 | — |
| DermAssociates, PC | Silver Spring | Maryland | 20902 | — |
| Beverly Johnson, MD | Silver Spring | Maryland | 20904 | — |
| Robert S. Berger | White Plains | Maryland | 20695 | — |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | — |
| Adult & Pediatric Dermatology | Marlborough | Massachusetts | 01752 | — |
| Kenneth M. Reed, MD | Quincy | Massachusetts | 02169 | — |
| Drs. Iacobelli & DiGregorio, PC | Clinton Township | Michigan | 48038 | — |
| Henry Ford Medical Center | Detroit | Michigan | 48202 | — |
| Hamzavi Dermatology | Fort Gratiot | Michigan | 48059 | — |
| Silverton Skin Institute | Grand Blanc | Michigan | 48439 | — |
| SVC Dermatology PC | Sterling Heights | Michigan | 48314 | — |
| Somerset Skin Centre | Troy | Michigan | 48084 | — |
| Grekin Skin Institute | Warren | Michigan | 48093 | — |
| Midwest Center for Dermatology and Cosmetic Surgery | Warren | Michigan | 48093 | — |
| Dermatology Center for Children and Young Adults | Eagan | Minnesota | 55121 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Asthma & Allergy Center of North Jackson | Jackson | Mississippi | 39206 | — |
| Peace Children's Clinic | Jackson | Mississippi | 39216 | — |
| North County Dermatology | Florissant | Missouri | 63031 | — |
| Kosse Pediatrics | Saint Joseph | Missouri | 64506 | — |
| South Lincoln Dermatology Clinic | Lincoln | Nebraska | 68502 | — |
| Skin Specialists PC | Omaha | Nebraska | 68144 | — |
| Bettencourt Skin Center | Henderson | Nevada | 89014 | — |
| Aistheta | Reno | Nevada | 89509 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Cheryl D. Ackerman | Glen Ridge | New Jersey | 07028 | — |
| CDLC | Ridgewood | New Jersey | 07450 | — |
| The Dermatology Group, PC | Verona | New Jersey | 07044 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| Allergy & Asthma Associates of NNM | Los Alamos | New Mexico | 87544 | — |
| New York Dermatology, P.C. | Bayside | New York | 11360 | — |
| Robert S. Darr, MD, PC | Brooklyn | New York | 11209 | — |
| Morris Westfried, M.D. | Brooklyn | New York | 11228 | — |
| Garden City Dermatology, P.C. | Garden City | New York | 11530 | — |
| Hollis Medisys | Hollis | New York | 11432 | — |
| Marvin S.Watsky | Lindenhurst | New York | 11757 | — |
| Orange Dermatology Assoc, PC | Monroe | New York | 10950 | — |
| St. Luke's Roosevelt Hospital Center | New York | New York | 10025 | — |
| Columbia University Medical Center., Dept. of Medicine | New York | New York | 10032 | — |
| Helendale Dermatology & Medical Spa, LLC | Rochester | New York | 14609 | — |
| Marina I Peredo, MD | Smithtown | New York | 11787 | — |
| Derm Research Center of New York, Inc. | Stony Brook | New York | 11790 | — |
| Joseph D. Sutton, MD | Suffern | New York | 10901 | — |
| Stanley A. Newfield | Valley Stream | New York | 11581 | — |
| Davie Dermatology | Advance | North Carolina | 27006 | — |
| Alamance Skin Center | Burlington | North Carolina | 27215 | — |
| Pediatrx Clinic | Fayetteville | North Carolina | 28305 | — |
| Southeastern Dermatology, PA | Lumberton | North Carolina | 28358 | — |
| FMC/OIC | Rocky Mount | North Carolina | 27801 | — |
| DermOne Dermatology Center, PA | Wilmington | North Carolina | 28401 | — |
| Carolina Dermatology & Skin Cancer Surgery | Wilmington | North Carolina | 28403 | — |
| Knox Clinic Pediatrics, PLLC | Wilmington | North Carolina | 28403 | — |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| Haber Dermatology and Cosmetic Surgery, Inc | Beachwood | Ohio | 44122 | — |
| University Dermatology Consultants, Inc. | Cincinnati | Ohio | 45219 | — |
| Dermatology Research Associates, Inc. | Cincinnati | Ohio | 45230 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Warren Dermatology & Allergy | Warren | Ohio | 44484 | — |
| Oklahoma University Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Brian Lepley, D.O. | Oklahoma City | Oklahoma | 73139 | — |
| Family Health Center South | Oklahoma City | Oklahoma | 73139 | — |
| OSU-CHS Houston Center Physicians | Tulsa | Oklahoma | 74127 | — |
| Philadelphia Institute of Dermatology | Fort Washington | Pennsylvania | 19034 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| East Penn Dermatology | North Wales | Pennsylvania | 19454 | — |
| Paddington Testing Co, Inc. | Philadelphia | Pennsylvania | 19103 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Clinical Partners, LLC | Johnston | Rhode Island | 02919 | — |
| Dermatology and Laser Center of Charleston | Charleston | South Carolina | 29414 | — |
| Cheraw Pediatrics, P.A. | Cheraw | South Carolina | 29520 | — |
| Dermatology Group LLC | Columbia | South Carolina | 29201 | — |
| McClerklin Skin and Laser Center | Columbia | South Carolina | 29203 | — |
| Allergic Disease & Asthma Center | Greenville | South Carolina | 29406 | — |
| National Allergy and Asthma Research, LLC | North Charleston | South Carolina | 29420 | — |
| Palmetto Skin & Laser Center | Rock Hill | South Carolina | 29732 | — |
| The Asthma Institute PLLC | Chattanooga | Tennessee | 37421 | — |
| Rivergate Dermatology Research Center | Goodlettsville | Tennessee | 37072 | — |
| Dermatology Associates of Kingsport, PC | Kingsport | Tennessee | 37660 | — |
| Allergy Associates, PA dba East Tennessee Center for Clinical Research | Knoxville | Tennessee | 37909 | — |
| Dermatology Associates of Knoxville, PC | Knoxville | Tennessee | 37917 | — |
| The Skin Wellness Center | Knoxville | Tennessee | 37922 | — |
| Sheffield Pediatrics, PLLC | Memphis | Tennessee | 38104 | — |
| Raleigh Group PC | Memphis | Tennessee | 38128 | — |
| Academy of Clinical Research | Arlington | Texas | 76002 | — |
| Arlington Center for Dermatology | Arlington | Texas | 76011 | — |
| Zoltan Trizna | Austin | Texas | 78759 | — |
| Allergy Partners North Texas Research | Dallas | Texas | 75230 | — |
| Dermatology Treatment and Research Center, PA | Dallas | Texas | 75230 | — |
| Western Sky Medical Research | El Paso | Texas | 79903 | — |
| University of N. Texas Health Science Center | Fort Worth | Texas | 76107 | — |
| North Texas Institute for Clinical Trials | Fort Worth | Texas | 76109 | — |
| Dermatology Center of Frisco | Frisco | Texas | 75035 | — |
| Pediatric Dermatology of North Texas PA | Grapevine | Texas | 76051 | — |
| Stephen Schwartz | Harlingen | Texas | 78550 | — |
| Heights Dermatology & Aesthetic Center | Houston | Texas | 77008 | — |
| University of Texas - Houston | Houston | Texas | 77030 | — |
| West Houston Dermatology, PA | Houston | Texas | 77082 | — |
| Bear Creek Clinic, PA | Houston | Texas | 77084 | — |
| Lone Star Children's Medical PLLC | Houston | Texas | 77092 | — |
| Dermatology and Laser Center | Irving | Texas | 75061 | — |
| Site US0048 | Irving | Texas | 75061 | — |
| Lubbock Dermatology and Skin Cancer Center | Lubbock | Texas | 79410 | — |
| Rick Lin, D.O., MPH | McAllen | Texas | 78504 | — |
| Pasadena Dermatology Clinic | Pasadena | Texas | 77506 | — |
| Medical Research Network | Spring | Texas | 77373 | — |
| Dermatology Research Associates of Tyler | Tyler | Texas | 75703 | — |
| Dermatology Research Center | Salt Lake City | Utah | 84117 | — |
| Brookside Pediatrics | Bennington | Vermont | 05201 | — |
| Glenn H. Fuchs, MD PC | Arlington | Virginia | 22204 | — |
| Dermatology Assoc of Northern Vineland | Centreville | Virginia | 20121 | — |
| Piedmont Dermatology Center, PC | Martinsville | Virginia | 24112 | — |
| Children's Hospital of the Kings Daughters | Norfolk | Virginia | 23507 | — |
| Virginia Clinical Research, Inc. | Norfolk | Virginia | 23507 | — |
| Dermatology Associates, PLLC | Seattle | Washington | 98101 | — |
| Asthma, Inc. | Seattle | Washington | 98115 | — |
| Eastern Washington Dermatology | Walla Walla | Washington | 99362 | — |
| Univeristy of Wisconsin-Madison | Madison | Wisconsin | 53792 | — |
| George V. Chandy MD SC | Milwaukee | Wisconsin | 53208 | — |
| Central Wyoming Skin Clinic | Casper | Wyoming | 82609 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 115 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00475605, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 17, 2019 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00475605 live on ClinicalTrials.gov.