Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT00487825. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 26-week, Phase II, Multi-center, Randomized, Double-blind, Placebo-controlled Study to Assess the Response to Treatment (ACR50) and to Determine a Biomarker Profile in Responders to ACZ885 (Anti-interleukin-1beta Monoclonal Antibody) Plus MTX as Compared to MTX Alone in Early Rheumatoid Arthritis Patients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study was intended to evaluate the safety and efficacy of intravenous (IV) ACZ885 and oral methotrexate (MTX) therapy in patients with early rheumatoid arthritis (RA)
Study identification
- NCT ID
- NCT00487825
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 78 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2007 (Type not available)
- Primary completion
- Dec 2008 (Actual)
- Completion
- Dec 2008 (Actual)
- Last update posted
- Aug 1, 2012
2007 – 2008
United States locations
- U.S. sites
- 17
- U.S. states
- 12
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheumatology Associates of Northern Alabama (Dr. William Shergy) | Huntsville | Alabama | 35801 | — |
| Clinic for Rheumatic Diseases (Dr. Richard Jones, III) | Tuscaloosa | Alabama | 35406 | — |
| Arizona Arthritis and Rheumatology Research (Dr. Paul Caldron) | Paradise Valley | Arizona | 85253 | — |
| Jacksonville Center for Clinical Research (Dr. Steven Mathews) | Jacksonville | Florida | 32216 | — |
| Center for Arthritis and Rheumatic Diseases (Dr. Michael Weitz) | South Miami | Florida | 33143 | — |
| West Broward Rheumatology Associates, Incorporated (Dr. Elias Halpert) | Tamarac | Florida | 33321 | — |
| Rockford Orthopedic Associates (Dr. Richard Olson) | Rockford | Illinois | 61107 | — |
| Mercy Arthritis and Osteoporosis Center (Dr. Alan Braun) | Urbandale | Iowa | 50322 | — |
| Clayton Medical Research (Dr. Iri Don) | Richmond Heights | Missouri | 63117 | — |
| Westroads Medical Group (Dr. William Palmer) | Omaha | Nebraska | 68114 | — |
| Arthritis Center of Reno (Dr. Malin Prupas) | Reno | Nevada | 89502 | — |
| Oklahoma Center for Arthritis therapy and Research (Dr. James McKay) | Tulsa | Oklahoma | 74104 | — |
| MetaClin Research, Incorporated (Dr. Paul Pickrell) | Austin | Texas | 78704 | — |
| John M. Joseph, MD (Dr. John Joseph) | Carlton | Texas | 75007 | — |
| Southwest Rheumatology, P.A. (Dr. Atul Singhal) | Mesquite | Texas | 75150 | — |
| Arthritis Clinic of Northern Virginia (Dr. Philip Kempf) | Arlington | Virginia | 22205 | — |
| Arthritis Northwest Rheumatology, PLLC (Dr. Jeffrey Butler) | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00487825, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 1, 2012 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00487825 live on ClinicalTrials.gov.