Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee
Public ClinicalTrials.gov record NCT00488267. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, 12-Week Study to Evaluate the Efficacy of ThermoProfen™ in the Treatment of Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee (ZMK-301)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
ThermoProfen is a transdermal ketoprofen patch that is integrated with a long-lasting CHADD (Controlled Heat-Assisted Drug Delivery) unit for the treatment of chronic pain associated with osteoarthritis. This study will evaluate ThermoProfen for the treatment of mild to moderate pain associated with osteoarthritis of the knee in adults.
Study identification
- NCT ID
- NCT00488267
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 679 participants
Conditions and interventions
Conditions
Interventions
- ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System) Drug
- Placebo Matrix/CHADD Patch Drug
- Ketoprofen matrix/placebo CHADD Patch Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2007 (Type not available)
- Primary completion
- Jun 2008 (Actual)
- Completion
- Sep 2008 (Actual)
- Last update posted
- May 30, 2012
2007 – 2008
United States locations
- U.S. sites
- 36
- U.S. states
- 20
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Peoria | Arizona | 85381 | — |
| Not listed | Anaheim | California | 92801 | — |
| Not listed | Buena Park | California | 90620 | — |
| Not listed | San Diego | California | 92103 | — |
| Not listed | Westlake Village | California | 91361 | — |
| Not listed | Hamden | Connecticut | 06518 | — |
| Not listed | Milford | Connecticut | 06460 | — |
| Not listed | Clearwater | Florida | 33761 | — |
| Not listed | Jupiter | Florida | 33458 | — |
| Not listed | Pembroke Pines | Florida | 33024 | — |
| Not listed | South Miami | Florida | 33143 | — |
| Not listed | Tampa | Florida | 33614 | — |
| Not listed | Boise | Idaho | 83704 | — |
| Not listed | Springfield | Illinois | 62704 | — |
| Not listed | Evansville | Indiana | 47714 | — |
| Not listed | Overland Park | Kansas | 66215 | — |
| Not listed | Baltimore | Maryland | 21239 | — |
| Not listed | Wheaton | Maryland | 20902 | — |
| Not listed | Lansing | Michigan | 48910 | — |
| Not listed | Kansas City | Missouri | 64114 | — |
| Not listed | Mercerville | New Jersey | 08619 | — |
| Not listed | Greensboro | North Carolina | 27408 | — |
| Not listed | Raleigh | North Carolina | 27612 | — |
| Not listed | Lake Oswego | Oregon | 97035 | — |
| Not listed | Portland | Oregon | 97239 | — |
| Not listed | Duncansville | Pennsylvania | 16635 | — |
| Not listed | Erie | Pennsylvania | 16508 | — |
| Not listed | Mechanicsburg | Pennsylvania | 17055 | — |
| Not listed | Anderson | South Carolina | 29621 | — |
| Not listed | Myrtle Beach | South Carolina | 29572 | — |
| Not listed | Nashville | Tennessee | 37205 | — |
| Not listed | Houston | Texas | 77090 | — |
| Not listed | San Antonio | Texas | 78217 | — |
| Not listed | Salt Lake City | Utah | 84106 | — |
| Not listed | Spokane | Washington | 99204 | — |
| Not listed | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00488267, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 30, 2012 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00488267 live on ClinicalTrials.gov.