Phase 2b Study of Taxol Plus Sorafenib or Placebo in Patients With Advanced Breast Cancer
Public ClinicalTrials.gov record NCT00499525. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Randomized Phase 2b Study Evaluating the Efficacy and Safety of Sorafenib Compared to Placebo When Administered in Combination With Paclitaxel in Patients With Locally Recurrent or Metastatic Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving paclitaxel together with sorafenib may kill more tumor cells. PURPOSE: This randomized phase II trial is studying how well paclitaxel works when given together with or without sorafenib in treating patients with locally recurrent or metastatic breast cancer.
Study identification
- NCT ID
- NCT00499525
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 180 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2007
- Primary completion
- Nov 30, 2020
- Completion
- Nov 30, 2022
- Last update posted
- May 2, 2019
2007 – 2022
United States locations
- U.S. sites
- 43
- U.S. states
- 22
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Northwest Alabama Cancer Center, PC - Muscle Shoals | Muscle Shoals | Alabama | 35661 | — |
| Highlands Oncology Group - Fayetteville | Fayetteville | Arkansas | 72703 | — |
| Pacific Cancer Medical Center, Incorporated | Anaheim | California | 92801 | — |
| Pacific Coast Hematology/Oncology Medical Group, Incorporated | Fountain Valley | California | 92708 | — |
| Desert Hematology-Oncology Medical Group, Incorporated | Rancho Mirage | California | 92270 | — |
| Sutter Cancer Center | Sacramento | California | 95816 | — |
| Cancer Prevention and Treatment Center at Dominican and Watsonville Community Hospital | Soquel | California | 95073 | — |
| Not listed | St. Helena | California | 94574 | — |
| Helen and Harry Gray Cancer Center at Hartford Hospital | Hartford | Connecticut | 06102-5037 | — |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Medical Oncology and Hematology, PC at Harold Leever Cancer Center | Waterbury | Connecticut | 06708 | — |
| George Washington University Cancer Institute | Washington D.C. | District of Columbia | 20037 | — |
| Pasco Hernando Oncology Associates, PA - Brooksville | Brooksville | Florida | 34613 | — |
| Pasco Hernando Oncology Associates, PA - New Port Richey | New Port Richey | Florida | 34652 | — |
| Northeast Georgia Cancer Care, LLC - Medical Oncology | Athens | Georgia | 30607 | — |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise | Idaho | 83712 | — |
| Hematology-Oncology Associates of Illinois | Chicago | Illinois | 60611-2998 | — |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | 60611-3013 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Cancer Institute at Alexian Brothers | Elk Grove Village | Illinois | 60007-3397 | — |
| Medical and Surgical Specialists, LLC | Galesburg | Illinois | 61401 | — |
| Hinsdale Hematology Oncology Associates | Hinsdale | Illinois | 60521 | — |
| Midwest Center for Hematology/Oncology | Joliet | Illinois | 60432 | — |
| Kellogg Cancer Care Center | Oak Park | Illinois | 60302 | — |
| Hematology/Oncology of the North Shore at Gross Point Medical Center | Skokie | Illinois | 60076 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46885-5099 | — |
| Family Medicine of Vincennes Clinical Trial Center | Vincennes | Indiana | 47591 | — |
| Kentuckiana Cancer Institute, PLLC | Louisville | Kentucky | 40202 | — |
| Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge | Louisiana | 70809-3482 | — |
| Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center | Columbia | Missouri | 65201 | — |
| Nebraska Hematology-Oncology, PC | Lincoln | Nebraska | 68510-2482 | — |
| Essex Oncology of North Jersey | Belleville | New Jersey | 07109 | — |
| Sussex County Medical Associates - Sparta | Sparta | New Jersey | 07871 | — |
| Piedmont Hematology-Oncology Associates | Winston-Salem | North Carolina | 27103 | — |
| Tri-County Hematology/Oncology Associates, Incorporated | Canton | Ohio | 44718 | — |
| Hematology Oncology Consultants, Incorporated | Columbus | Ohio | 43235 | — |
| North Coast Cancer Care, Incorporated | Sandusky | Ohio | 44870 | — |
| Hematology and Oncology Associates of Rhode Island | Cranston | Rhode Island | 02920 | — |
| West Clinic - East Memphis | Memphis | Tennessee | 38120 | — |
| Patients' Comprehensive Cancer Center - Carrollton | Carrollton | Texas | 75010-4602 | — |
| Oncology Consultants - Memorial City | Houston | Texas | 77024 | — |
| Cascade Cancer Center at Evergreen Hospital Medical Center | Kirkland | Washington | 98034-3013 | — |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse | Wisconsin | 54601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00499525, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2019 · Synced Sep 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00499525 live on ClinicalTrials.gov.