Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD
Public ClinicalTrials.gov record NCT00499590. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-masked, Parallel-assignment Study of Intravitreal Bevasiranib Sodium, Administered Every 8 or 12 Weeks as Maintenance Therapy Following Three Injections of Lucentis® Compared With Lucentis® Monotherapy Every 4 Weeks in Patients With Exudative Age-Related Macular Degeneration (AMD).
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the safety and effectiveness of bevasiranib given either every 8 weeks or every 12 weeks after an initial pre-treatment with 3 injections of Lucentis® (ranibizumab injection) compared to Lucentis® given every 4 weeks to people with wet AMD. Patients will be assigned at random (like tossing a coin) to receive one of three treatments options for 104 weeks.
Study identification
- NCT ID
- NCT00499590
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 338 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2007 (Type not available)
- Primary completion
- Mar 2009 (Actual)
- Completion
- May 2009 (Actual)
- Last update posted
- Oct 6, 2014
2007 – 2009
United States locations
- U.S. sites
- 55
- U.S. states
- 24
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Consultants of Arizona (site 209) | Phoenix | Arizona | 85014 | — |
| Associated Retina Consultants (site 286) | Phoenix | Arizona | 85020 | — |
| Retina Centers PC (site 215) | Tucson | Arizona | 85704 | — |
| Eye Medical Center (site 287) | Fresno | California | 93720 | — |
| Northern California Retina Vitreous Associates (site 320) | Mountain View | California | 94040 | — |
| Retina Institute of California (site 207) | Pasadena | California | 91105 | — |
| Retina Consultants San Diego (site 232) | Poway | California | 93064 | — |
| Retinal Consultants Medical Group (site 289) | Sacramento | California | 95819 | — |
| Orange County Retina Medical Group (site 252) | Santa Ana | California | 92705 | — |
| Miramar Eye Specialists Medical Group (site 245) | Ventura | California | 93003 | — |
| The Eye Care Group, PC (site 315) | Waterbury | Connecticut | 06708 | — |
| Florida Eye Clinic (site 257) | Altamonte Springs | Florida | 32701 | — |
| Florida Eye Microsurgical Institute, Inc. (site 217) | Boynton Beach | Florida | 33426 | — |
| Retina Health Center (site 247) | Fort Myers | Florida | 33901 | — |
| National Ophthalmic Research Institute at Retina Consultants of SW Florida (site 270) | Fort Myers | Florida | 33912 | — |
| Magruder Eye Institute (site 264) | Orlando | Florida | 32803 | — |
| Southern Vitreoretinal Associates, PL (site 309) | Tallahassee | Florida | 32308 | — |
| University of South Florida Eye Institute (site 311) | Tampa | Florida | 33612 | — |
| Center for Retina and Macular Disease (site 293) | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center (site 268) | Augusta | Georgia | 30909 | — |
| Midwest Eye Institute (site 253) | Indianapolis | Indiana | 46280 | — |
| Retina Associates, PA (site 295) | Shawnee Mission | Kansas | 66204 | — |
| Vitreo-Retinal Consultants & Surgeons, P.A. (site 274) | Wichita | Kansas | 67214 | — |
| Eye Centers of Louisville (site 251) | Louisville | Kentucky | 40207 | — |
| Retina Specialists (site 231) | Towson | Maryland | 21204 | — |
| Retina Associates St. Louis (site 300) | Florissant | Missouri | 63031 | — |
| Eye Foundation of Kansas City Truman Medical Center (site 272) | Kansas City | Missouri | 64108 | — |
| Retinal Consultants of Nevada (site 273) | Las Vegas | Nevada | 89144 | — |
| Eyesight Ophthalmic Services, PA (site 290) | Portsmouth | New Hampshire | 03801 | — |
| Delaware Valley Retina Associates (site 261) | Lawrenceville | New Jersey | 08648 | — |
| Retina-Vitreous Consultants (site 216) | Livingston | New Jersey | 07039 | — |
| Retina Associates of New Jersey (site 298) | Teaneck | New Jersey | 07666 | — |
| Capital Region Retina (site 316) | Albany | New York | 12206 | — |
| New York Eye & Ear Infirmary (site 272) | New York | New York | 10003 | — |
| Vitreous-Retina-Macula Consultants of New York (site 239) | New York | New York | 10022 | — |
| Carolina Eye Associates (site 308) | Southern Pines | North Carolina | 28387 | — |
| Retina Associates of Cleveland (site 228) | Beachwood | Ohio | 44122 | — |
| Cincinnati Eye Institute (site 285) | Cincinnati | Ohio | 45242 | — |
| Retina Associates of Cleveland, Inc. (site 219) | Lakewood | Ohio | 44107 | — |
| Retina-Vitreous Associates (site 266) | Toledo | Ohio | 43608 | — |
| Retina and Vitreous Center of Southern Oregon (site 271) | Ashland | Oregon | 97520 | — |
| Ophthalmology Associates of PA (site 297) | Bala-Cynwyd | Pennsylvania | 19004 | — |
| Palmetto Retina Center (site 275) | West Columbia | South Carolina | 29169 | — |
| Black Hills Regional Eye Institute (site 202) | Rapid City | South Dakota | 57701 | — |
| Southeastern Retina Associates, PC (Site 250) | Knoxville | Tennessee | 37909 | — |
| Retina Research Institute of Texas, L.L.C. (site 269) | Abilene | Texas | 79606 | — |
| Austin Retina Associates (site 304) | Austin | Texas | 78705 | — |
| Retina Research Center (site 204) | Austin | Texas | 78705 | — |
| University of Texas Medical Branch- Galveston (site 301 | Galveston | Texas | 77555 | — |
| Houston Eye Associates (site 321) | Houston | Texas | 77025 | — |
| Valley Retina Institue, PA (site 258) | McAllen | Texas | 78503 | — |
| Eye Care Associates of East Texas (site 282) | Tyler | Texas | 75701 | — |
| Rocky Mountain Retina Consultants (site 256) | Salt Lake City | Utah | 84107 | — |
| University of Utah, John A. Moran Eye Center (site 205) | Salt Lake City | Utah | 84132 | — |
| University of Virginia- Ophthalmology Dept. (site 254) | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00499590, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2014 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00499590 live on ClinicalTrials.gov.