ClinicalTrials.gov record
Velcade,Thalidomide, and Dexamethasone Versus Velcade and Dexamethasone Versus Velcade, Melphalan, and Prednisone
ClinicalTrials.gov ID: NCT00507416
Public ClinicalTrials.gov record NCT00507416. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase 3b Study of Three Treatment Regimens in Subjects With Previously Untreated Multiple Myeloma Who Are Not Considered Candidates for High-Dose Chemotherapy and Autologous Stem Cell Transplantation: VELCADE, Thalidomide, and Dexamethasone Versus VELCADE and Dexamethasone Versus VELCADE, Melphalan, and Prednisone
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, open label, multicenter clinical trial to compare the efficacy and safety of Velcade (bortezomib) and dexamethasone versus Velcade, thalidomide, and dexamethasone versus Velcade, melphalan, and prednisone in patients with previously untreated multiple myeloma not considered candidates for high-dose chemotherapy and autologous stem cell transplantation.
Study identification
- NCT ID
- NCT00507416
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 502 participants
Conditions and interventions
Conditions
Interventions
- Bortezomib Drug
- Dexamethasone Drug
- Melphalan Drug
- Prednisone Drug
- Thalidomide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2007
- Primary completion
- Feb 28, 2013
- Completion
- Feb 28, 2013
- Last update posted
- Apr 30, 2014
2007 – 2013
United States locations
- U.S. sites
- 234
- U.S. states
- 43
- U.S. cities
- 208
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham Hematology Oncology Assciates, LLC | Birmingham | Alabama | 35205 | — |
| Desert Oasis Cancer Center | Casa Grande | Arizona | 85222 | — |
| Northern Arizona Hematology & Oncology Associates - AOA | Sedona | Arizona | 86336 | — |
| Arizona Oncology Associates | Tucson | Arizona | 85704 | — |
| Heritage Physician Group Oncology | Hot Springs | Arkansas | 71913 | — |
| Hematology Oncology Services of Arkansas | Little Rock | Arkansas | 72205 | — |
| Pacific Cancer Medical Centre | Anaheim | California | 92801 | — |
| Tower Cancer Research Foundation | Beverly Hills | California | 90211-1850 | — |
| Compassionate Cancer Care Medical Group | Corona | California | 92882 | — |
| Compassionate Cancer Care Medical Group, Inc. | Fountain Valley | California | 92708 | — |
| Robert A. Moss, MD, FACP, Inc. | Fountain Valley | California | 92708 | — |
| Cancer Care Associates | Fresno | California | 93720 | — |
| Glendale Memorial Hospital & Health Center | Glendale | California | 91204 | — |
| California Cancer Care | Greenbrae | California | 94904 | — |
| Beaver Medical Group | Highland | California | 92346 | — |
| Edward A. Wagner, MD | Laguna Beach | California | 92882 | — |
| Clinical Trials and Research Associates, Inc. | Montebello | California | 90640 | — |
| Medical Oncology Care Associates | Orange | California | 92868 | — |
| Ventura County Hematology Oncology Specialists | Oxnard | California | 93030 | — |
| Southwest Cancer Care | Poway | California | 92064 | — |
| Desert Cancer Care, Incorporated | Rancho Mirage | California | 92270 | — |
| Compassionate Cancer Care Medical Group, Inc. | Riverside | California | 92501 | — |
| Sutter Cancer Center | Sacramento | California | 95816 | — |
| Cancer Research & Prevention Center | Soquel | California | 95073 | — |
| Stockton Hematology/Oncology | Stockton | California | 95204 | — |
| Trivalley Oncology Hematology | Westlake Village | California | 91361 | — |
| Rocky Mountain Cancer Center | Denver | Colorado | 80218 | — |
| Cancer Center of Central Connecticut | Southington | Connecticut | 06489 | — |
| Christiana Care Health Services | Newark | Delaware | 19718 | — |
| The Center for Hematology-Oncology | Boca Raton | Florida | 33486 | — |
| Pasco Hernando Oncology | Brooksville | Florida | 34613 | — |
| Northwest Oncology & Hematology Associates | Coral Springs | Florida | 33065 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Horizon Institute for Clinical Research | Hollywood | Florida | 33021 | — |
| Baptist Cancer Institute | Jacksonville | Florida | 32207 | — |
| University of Florida- Jacksonville | Jacksonville | Florida | 32209 | — |
| Cancer Care of North Florida | Lake City | Florida | 32024 | — |
| Lakeland Regional Cancer Center | Lakeland | Florida | 33805 | — |
| Cancer & Blood Disease Center | Lecanto | Florida | 34461 | — |
| Pasco Hernando Oncology | New Port Richey | Florida | 34652 | — |
| Florida Cancer Institute | New Port Richey | Florida | 34655 | — |
| Innovative Medical Research of South Florida Inc. | North Miami Beach | Florida | 33179 | — |
| Ocala Oncology Center | Ocala | Florida | 34474 | — |
| Cancer Centers of Florida, P.A. | Ocoee | Florida | 34761 | — |
| MD Anderson Cancer Center Orlando | Orlando | Florida | 32806 | — |
| Hematology Oncology Associates of the Treasure Coast, PA | Port Saint Lucie | Florida | 34952 | — |
| Gulfcoast Oncology Associates | St. Petersburg | Florida | 33705 | — |
| S. Florida Oncology/ Hematology | West Palm Beach | Florida | 33458 | — |
| Medical Oncology Associates of Augusta | Augusta | Georgia | 30901 | — |
| Central Georgia Cancer Care | Macon | Georgia | 31201 | — |
| Northwest Georgia Oncology Centers, P.C. | Marietta | Georgia | 30060 | — |
| Summit Cancer Care | Savannah | Georgia | 31405 | — |
| St. Lukes Mountain States Tumor Institute | Boise | Idaho | 83712 | — |
| Snake River Oncology of Eastern Idaho, PLLC. | Idaho Falls | Idaho | 83404 | — |
| Cancer Care & Hematology Specialists of Chicagoland | Arlington Heights | Illinois | 60005 | — |
| Hematology Oncology Associates of Illinois | Chicago | Illinois | 60611 | — |
| John H. Stroger, Jr. Hospital of Cook County | Chicago | Illinois | 60612 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Hematology Oncology Associates of Illinois | Chicago | Illinois | 60657 | — |
| Elmhurst Memorial Hospital | Elmhurst | Illinois | 60126 | — |
| Oncology Hematology Associates of North Illinois Ltd. | Gurnee | Illinois | 60031-3399 | — |
| Midwest Center for Hematology / Oncology | Joliet | Illinois | 60432 | — |
| Joliet Oncology-Hematology Associates, Ltd. | Joliet | Illinois | 60435 | — |
| Hematology Oncology Consultants, Inc. | Naperville | Illinois | 60540 | — |
| Cancer Care and Hematology Specialists of Chicagoland | Niles | Illinois | 60714 | — |
| Mid-Illinois Hem & Onc | Normal | Illinois | 61761 | — |
| Quincy Medical Group | Quincy | Illinois | 62301 | — |
| Deaconess Clinic Incorporated | Evansville | Indiana | 47713 | — |
| Central Indiana Cancer Centers | Indianapolis | Indiana | 46227 | — |
| Investigative Clinical Research of Indiana, LLC | Indianapolis | Indiana | 46254 | — |
| Clarian Arnett Cancer Center | Lafayette | Indiana | 47904 | — |
| Medical Consultants, PC | Muncie | Indiana | 47303 | — |
| Cancer Care Center | New Albany | Indiana | 47150 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Hope Center | Terre Haute | Indiana | 47802 | — |
| McFarland Clinic, P.C. | Ames | Iowa | 50010 | — |
| Heartland Hematology-Oncology Associates, Inc. | Council Bluffs | Iowa | 51503 | — |
| Siouxland Hematology/Oncology Assoc., LLP | Sioux City | Iowa | 51101 | — |
| Kansas City Cancer Centers - Southwest | Overland Park | Kansas | 66210 | — |
| Cancer Center of Kansas | Wichita | Kansas | 67214 | — |
| Commonwealth Cancer Center | Danville | Kentucky | 40422 | — |
| Kentucky Cancer Clinic | Hazard | Kentucky | 41701 | — |
| Western Kentucky Hematology and Oncology Group | Paducah | Kentucky | 42003 | — |
| Christus St. Francis Cabrini Cancer Center | Alexandria | Louisiana | 71301 | — |
| Hematology-Oncology Clinic | Baton Rouge | Louisiana | 70809 | — |
| Annapolis Oncology Center | Annapolis | Maryland | 21401 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| St. Agnes Health Care | Baltimore | Maryland | 21229 | — |
| Auerbach Hematology Oncology Associates | Baltimore | Maryland | 21237 | — |
| Maryland Hematology Oncology Association | Baltimore | Maryland | 21237 | — |
| Center for Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| Oncology-Hematology Associates, P.A. | Clinton | Maryland | 20735 | — |
| Maryland Oncology Hematology, PA | Columbia | Maryland | 21044 | — |
| Carroll County Cancer Center | Westminster | Maryland | 21157 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Fallon Clinic at Worcester Medical Center | Worcester | Massachusetts | 01608-1320 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Cancer & Hematology Centers of Western Michigan | Grand Rapids | Michigan | 49546 | — |
| Kalamazoo Hematology and Oncology | Kalamazoo | Michigan | 49048 | — |
| Hematology Oncology Associates of Ohio & Michigan, PC | Lambertville | Michigan | 48144 | — |
| Breslin Cancer Center / Great Lakes Cancer Institute | Lansing | Michigan | 48910 | — |
| Oncology Care Associates, P.L.L.C. | Saint Joseph | Michigan | 49085 | — |
| Providence Cancer Center | Southfield | Michigan | 48075 | — |
| Osteopathic Medical Hematology & Oncology | Woodhaven | Michigan | 48183 | — |
| St. Luke's Hospital | Duluth | Minnesota | 55805 | — |
| Metro MN CCOP | Minneapolis | Minnesota | 55416 | — |
| Hubert H. Humphrey Cancer Center | Robbinsdale | Minnesota | 55422 | — |
| St. Louis Cancer Center | Chesterfield | Missouri | 63017 | — |
| Capital Region Medical Center/Cancer Center | Jefferson City | Missouri | 65109 | — |
| Heartland Hematology-Oncology Associates, Inc. | Kansas City | Missouri | 64118 | — |
| Kansas City Veterans Administration Medical Center | Kansas City | Missouri | 64128 | — |
| St. Joseph Oncology | Saint Joseph | Missouri | 64507 | — |
| Great Falls Clinic, LLP | Great Falls | Montana | 59405 | — |
| Great Plains Regional Medical Center | North Platte | Nebraska | 69101 | — |
| Creighton Cancer Center | Omaha | Nebraska | 68131-2137 | — |
| Las Vegas Cancer Center | Henderson | Nevada | 89052 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| Veterans Affairs New Jersey Healthcare System | East Orange | New Jersey | 07018 | — |
| Drs. Forte, Schleider, Attas and Condemi, PA | Englewood | New Jersey | 07631 | — |
| St. Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Newark Beth Israel Hospital | Newark | New Jersey | 07112 | — |
| Somerset Hematology Oncology Associates | Somerville | New Jersey | 08876 | — |
| Sparta Cancer Center | Sparta | New Jersey | 07871 | — |
| New Mexico Cancer Care Associates | Santa Fe | New Mexico | 87505 | — |
| Stratton VA Medical Center IRB | Albany | New York | 12208 | — |
| Buffalo Institute for Medical Research, Inc. | Buffalo | New York | 14215 | — |
| Erie County Medical Center | Buffalo | New York | 14215 | — |
| Goshen Medical Associates | Goshen | New York | 10924 | — |
| Huntington Medical Group | Huntington Station | New York | 11746 | — |
| North Shore-Long Island Jewish Health System | Lake Success | New York | 11042 | — |
| Arena Oncology Associates | New Hyde Park | New York | 11042 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10021 | — |
| New York Presbyterian Hospital-Cornell Campus | New York | New York | 10021 | — |
| Interlakes Foundation, Inc. | Rochester | New York | 14623 | — |
| Richmond University Medical Center | Staten Island | New York | 10301 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Eastchester Center for Cancer Care | The Bronx | New York | 10469 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Cancer Care of WNC | Asheville | North Carolina | 28801 | — |
| Alamance Regional Medical Center | Burlington | North Carolina | 27215 | — |
| Blood and Cancer Clinic | Fayetteville | North Carolina | 28304 | — |
| Gaston Hematology & Oncology | Gastonia | North Carolina | 28054 | — |
| Carolina Oncology Specialist, PA | Hickory | North Carolina | 28603 | — |
| Emerywood Hematology/Oncology | High Point | North Carolina | 27262 | — |
| Raleigh Hematology Oncology / Associates, P.C. | Raleigh | North Carolina | 27607 | — |
| Hanover Medical Specialists, P.A. | Wilmington | North Carolina | 28401 | — |
| St. Alexius Clinical Research Services | Bismarck | North Dakota | 58501 | — |
| Gabrail Cancer Center | Canton | Ohio | 44718 | — |
| Oncology Hematology Care, Inc. | Cincinnati | Ohio | 45215 | — |
| Oncology Partners Network | Cincinnati | Ohio | 45247 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| Hematology Oncology Consultants Inc. | Columbus | Ohio | 43235 | — |
| Dayton Clinical Oncology Program | Dayton | Ohio | 45429 | — |
| Dayton Oncology & Hematology | Kettering | Ohio | 45409 | — |
| Toledo Community Hospital Oncology Program | Toledo | Ohio | 43617 | — |
| Trilogy Cancer Center | Wooster | Ohio | 44691 | — |
| Cancer Care Associates | Oklahoma City | Oklahoma | 73112 | — |
| Oklahoma Oncology and Hematology | Tulsa | Oklahoma | 74136 | — |
| Willamette Valley Cancer Center | Eugene | Oregon | 97401 | — |
| Onc-Hem of Lehigh Valley, PC | Bethlehem | Pennsylvania | 18015 | — |
| Hematology & Oncology Associates of NEPA | Dunmore | Pennsylvania | 18512 | — |
| Medical Oncology Associates | Kingston | Pennsylvania | 18704 | — |
| Regional Hematology Oncology Associates | Langhorne | Pennsylvania | 19047 | — |
| Greater Philadelphia Cancer and Hematology Specialists, PC | Philadelphia | Pennsylvania | 19114 | — |
| UPMC Cancer Pavillioin | Pittsburgh | Pennsylvania | 15232 | — |
| Guthrie Research Institute | Sayre | Pennsylvania | 18840 | — |
| Scranton Hematology Oncology | Scranton | Pennsylvania | 18510 | — |
| Roger Williams Medical Center | Providence | Rhode Island | 02908 | — |
| MUSC Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Cancer Center of the Carolinas | Greenville | South Carolina | 29605 | — |
| Low Country Hematology & Oncology | Mt. Pleasant | South Carolina | 29464 | — |
| Santee Hematology/Oncology | Sumter | South Carolina | 29150 | — |
| Avera Research Institute | Sioux Falls | South Dakota | 57105 | — |
| Chattanooga Oncology Hematology Associates | Chattanooga | Tennessee | 37404 | — |
| The Family Cancer Center, PLLC | Collierville | Tennessee | 38017 | — |
| The Cancer Center of Cookeville Regional Medical Center | Cookeville | Tennessee | 38501 | — |
| The Jones Clinic | Germantown | Tennessee | 38138 | — |
| East Tennessee Oncology/Hematology | Knoxville | Tennessee | 37920 | — |
| University of Tennesee Medical Center | Knoxville | Tennessee | 37920 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Texas Cancer Center | Abilene | Texas | 79606-5208 | — |
| Texas Oncology, P.A. | Arlington | Texas | 76014 | — |
| Southwest Regional Cancer Center | Austin | Texas | 78705 | — |
| Texas Oncology, PA | Austin | Texas | 78731 | — |
| Texas Oncology, PA | Beaumont | Texas | 77702 | — |
| Texas Oncology, P.A. | Bedford | Texas | 76022 | — |
| Coastal Bend Cancer Center | Corpus Christi | Texas | 73112 | — |
| South Texas Institute of Cancer and Blood Disorders | Corpus Christi | Texas | 78405 | — |
| Texas Oncology | Dallas | Texas | 75230-2510 | — |
| Dallas Oncology Consultants | Dallas | Texas | 75237 | — |
| Texas Oncology, PA / Methodist Charlton Cancer Center | Dallas | Texas | 75237 | — |
| Texas Oncology PA | Dallas | Texas | 75246 | — |
| Texas Cancer Center | Denton | Texas | 76210 | — |
| El Paso Cancer Treatment Center | El Paso | Texas | 79902 | — |
| Texas Cancer Center | Fort Worth | Texas | 76104 | — |
| Texas Oncology, PA | Garland | Texas | 75042 | — |
| Lee C. Drinkard, MD | Grapevine | Texas | 76051 | — |
| Houston Cancer Institute | Houston | Texas | 77055 | — |
| Medicus Alliance Clinical Research Organization, LLC | Houston | Texas | 77090 | — |
| Lake Vista Cancer Center | Lewisville | Texas | 75067 | — |
| Longview Cancer Center | Longview | Texas | 75601 | — |
| Texas Cancer Center of Mesquite | Mesquite | Texas | 75150 | — |
| Texas Oncology, P.A. | Midland | Texas | 79701 | — |
| Texas Oncology - Odessa | Odessa | Texas | 79761 | — |
| Paris Regional Cancer Center | Paris | Texas | 75460 | — |
| Cancer Care Network of South Texas | San Antonio | Texas | 78217 | — |
| Cancer Care Center of South Texas | San Antonio | Texas | 78229 | — |
| CTRC Institute for Drug Development | San Antonio | Texas | 78245 | — |
| Texas Cancer Center - Sherman | Sherman | Texas | 75090 | — |
| Blood and Cancer Center of East Texas | Tyler | Texas | 75701 | — |
| Tyler Hematology/Oncology, PA | Tyler | Texas | 75701 | — |
| Texas Oncology, PA | Tyler | Texas | 75702 | — |
| Texas Oncology | Waco | Texas | 76712 | — |
| Northern Utah Associates | Ogden | Utah | 84403 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| The University of Vermont | Burlington | Vermont | 05401 | — |
| White River Junction VAMC | White River Junction | Vermont | 05009-001 | — |
| Cancer Specialists of Tidewater | Chesapeake | Virginia | 23320 | — |
| Fairfax/Northern Virginia Hematology/Oncology | Fairfax | Virginia | 22031 | — |
| Lynchburg Hematology Oncology Clinic, Inc. | Lynchburg | Virginia | 24501 | — |
| Peninsula Cancer Institute Riverside Cancer Center | Newport News | Virginia | 23601 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23230 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc. | Salem | Virginia | 24153 | — |
| Masoom Kandahari, MD, PC | Woodbridge | Virginia | 22191 | — |
| Puget Sound Cancer Center - Edmonds | Edmonds | Washington | 98026 | — |
| Providence Everett Medical Center | Everett | Washington | 98201 | — |
| Puget Sound Cancer Center, Inc | Seattle | Washington | 98133 | — |
| Cancer Care Northwest, US Oncology | Spokane | Washington | 99202 | — |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801 | — |
| Yakima Valley Memorial Hospital / North Star Lodge | Yakima | Washington | 98902 | — |
| Gundersen Clinic, Ltd. | La Crosse | Wisconsin | 54601 | — |
| Alyce & Elmore Kraemer Cancer Center | West Bend | Wisconsin | 53095 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00507416, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2014 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00507416 live on ClinicalTrials.gov.