CRx-102 Osteoarthritis Multicenter Evaluation Trial
Public ClinicalTrials.gov record NCT00521989. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy of CRx-102 in Subjects With Symptomatic Knee Osteoarthritis and Optional One-Year Extension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
CRx-102 is a synergistic combination drug candidate containing the cardiovascular drug dipyridamole and a very low dose of the glucocorticoid prednisolone. CRx-102 is believed to work through a novel mechanism of action in which dipyridamole selectively amplifies the anti-inflammatory and immunomodulatory activities of the glucocorticoid without replicating the dose-dependent adverse effects. CRx-102 has been associated with clinical benefit in proof of concept studies in subjects with hand OA and RA. This is the first study to explore the efficacy of CRx-102 in knee OA. It is considered a dose-finding study and will also compare the potential benefits of CRx-102 treatment to both prednisolone administered alone and to placebo in this indication.
Study identification
- NCT ID
- NCT00521989
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 279 participants
Conditions and interventions
Conditions
Interventions
- CRx-102 (2.7/90) Drug
- Prednisolone Drug
- Placebo Drug
- CRx-102 (2.7/180) Drug
- CRx-102 (2.7/360) Drug
Drug
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2007 (Type not available)
- Primary completion
- Jul 2009 (Actual)
- Completion
- Jul 2009 (Actual)
- Last update posted
- Apr 29, 2014
2007 – 2009
United States locations
- U.S. sites
- 57
- U.S. states
- 27
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Huntsville | Alabama | — | — |
| Not listed | Chandler | Arizona | — | — |
| Not listed | Mesa | Arizona | — | — |
| Not listed | Phoenix | Arizona | — | — |
| Not listed | Tuscon | Arizona | — | — |
| Not listed | Little Rock | Arkansas | — | — |
| Not listed | Anaheim | California | — | — |
| Not listed | Rancho Mirage | California | — | — |
| Not listed | Upland | California | — | — |
| Not listed | Westlake Village | California | — | — |
| Not listed | DeLand | Florida | — | — |
| Not listed | Jupiter | Florida | — | — |
| Not listed | Kissimee | Florida | — | — |
| Not listed | Largo | Florida | — | — |
| Not listed | Longwood | Florida | — | — |
| Not listed | Palm Harbor | Florida | — | — |
| Not listed | Sarasota | Florida | — | — |
| Not listed | Tampa | Florida | — | — |
| Not listed | Atlanta | Georgia | — | — |
| Not listed | Paducah | Kentucky | — | — |
| Not listed | Covington | Louisiana | — | — |
| Not listed | Towson | Maryland | — | — |
| Not listed | Brockton | Massachusetts | — | — |
| Not listed | Haverhill | Massachusetts | — | — |
| Not listed | Peabody | Massachusetts | — | — |
| Not listed | Worcester | Massachusetts | — | — |
| Not listed | Bingham Farms | Michigan | — | — |
| Not listed | Missoula | Montana | — | — |
| Not listed | Reno | Nevada | — | — |
| Not listed | Haddon Heights | New Jersey | — | — |
| Not listed | Voorhees Township | New Jersey | — | — |
| Not listed | Albuquerque | New Mexico | — | — |
| Not listed | New York | New York | — | — |
| Not listed | Plainview | New York | — | — |
| Not listed | Rochester | New York | — | — |
| Not listed | Hickory | North Carolina | — | — |
| Not listed | High Point | North Carolina | — | — |
| Not listed | Winston-Salem | North Carolina | — | — |
| Not listed | Fargo | North Dakota | — | — |
| Not listed | Cincinnati | Ohio | — | — |
| Not listed | Dayton | Ohio | — | — |
| Not listed | Mayfield Village | Ohio | — | — |
| Not listed | Oklahoma City | Oklahoma | — | — |
| Not listed | Eugene | Oregon | — | — |
| Not listed | Duncansville | Pennsylvania | — | — |
| Not listed | Pittsburgh | Pennsylvania | — | — |
| Not listed | West Reading | Pennsylvania | — | — |
| Not listed | Cumberland | Rhode Island | — | — |
| Not listed | Warwick | Rhode Island | — | — |
| Not listed | Dallas | Texas | — | — |
| Not listed | Houston | Texas | — | — |
| Not listed | San Antonio | Texas | — | — |
| Not listed | Bountiful | Utah | — | — |
| Not listed | Sandy City | Utah | — | — |
| Not listed | Roanoke | Virginia | — | — |
| Not listed | Virginia Beach | Virginia | — | — |
| Not listed | Tacoma | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00521989, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 29, 2014 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00521989 live on ClinicalTrials.gov.