Tezosentan in the Treatment of Acute Heart Failure
Public ClinicalTrials.gov record NCT00524433. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Study to Assess the Efficacy, Safety, and Tolerability of Tezosentan in Patients With Acute Heart Failure.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The randomized patients with acute heart failure will be stratified based on the presence or absence of a Swan-Ganz catheter and assigned to receive either tezosentan 5 mg/h for the first 30 minutes and 1 mg/h thereafter or matching placebo in a 1:1 manner. The duration of the treatment is 24 hours up to 72 hours. The duration of the follow-up period is 30 days after treatment initiation for death, re-hospitalizations and SAEs followed by a follow-up period of 5 months for vital status.
Study identification
- NCT ID
- NCT00524433
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 713 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2003 (Type not available)
- Primary completion
- Jan 2005 (Actual)
- Completion
- Jan 2005 (Actual)
- Last update posted
- Jul 10, 2018
2003 – 2005
United States locations
- U.S. sites
- 16
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Oracle Research | Huntsville | Alabama | — | — |
| USC Medical Center | Los Angeles | California | — | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | — | — |
| University of Miami-Jackson Memorial Hospital | Miami | Florida | — | — |
| University Hospital | Augusta | Georgia | — | — |
| University of Iowa Hospital and Clinics | Iowa City | Iowa | — | — |
| Medical Research Institute | Slidell | Louisiana | — | — |
| Baystate Medical Center-Cardiology Section | Springfield | Massachusetts | — | — |
| Elmhurst Hospital Center | Elmhurst | New York | — | — |
| Columbia Presbyterian Medical Center-Heart Failure Center | New York | New York | — | — |
| New York University School of Medicine | New York | New York | — | — |
| University of North Carolina | Chapel Hill | North Carolina | — | — |
| Duke University Medical Center | Durham | North Carolina | — | — |
| LeBauer Cardiovascular Research Foundation | Greensboro | North Carolina | — | — |
| Baylor College of Medicine - Texas Medical Center | Houston | Texas | — | — |
| University of Texas, MD Anderson Cancer Center | Houston | Texas | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00524433, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 10, 2018 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00524433 live on ClinicalTrials.gov.