ClinicalTrials.gov record
High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
ClinicalTrials.gov ID: NCT00533949
Public ClinicalTrials.gov record NCT00533949. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Comparison of Standard-Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy With Concurrent and Consolidation Carboplatin/Paclitaxel +/- Cetuximab (IND #103444) in Patients With Stage IIIA/IIIB Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.
Study identification
- NCT ID
- NCT00533949
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 544 participants
Conditions and interventions
Conditions
Interventions
- Cetuximab Biological
- Carboplatin Drug
- Paclitaxel Drug
- 60 Gy RT Radiation
- 74 Gy RT Radiation
Biological · Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 31, 2007
- Primary completion
- May 31, 2013
- Completion
- May 19, 2022
- Last update posted
- Jun 20, 2022
2007 – 2022
United States locations
- U.S. sites
- 207
- U.S. states
- 42
- U.S. cities
- 173
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Comprehensive Cancer Center | Birmingham | Alabama | 35294 | — |
| Mayo Clinic Scottsdale | Scottsdale | Arizona | 85259-5499 | — |
| Arizona Oncology - Tucson | Tucson | Arizona | 85704 | — |
| Mercy Cancer Center at Mercy San Juan Medical Center | Carmichael | California | 95608 | — |
| Enloe Cancer Center at Enloe Medical Center | Chico | California | 95926 | — |
| Cancer Care Center at John Muir Health - Concord Campus | Concord | California | 94524-4110 | — |
| Saint Agnes Cancer Center at Saint Agnes Medical Center | Fresno | California | 93720 | — |
| Rebecca and John Moores UCSD Cancer Center | La Jolla | California | 92093-0658 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| St. Joseph Hospital Regional Cancer Center - Orange | Orange | California | 92868 | — |
| Feather River Hospital Cancer Center | Paradise | California | 95969 | — |
| Radiation Oncology Center - Roseville | Roseville | California | 95661 | — |
| Radiological Associates of Sacramento Medical Group, Incorporated | Sacramento | California | 95815 | — |
| University of California Davis Cancer Center | Sacramento | California | 95817 | — |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| Saint Helena Hospital | St. Helena | California | 94574 | — |
| Stanford Cancer Center | Stanford | California | 94305-5824 | — |
| Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | 80933 | — |
| Swedish Medical Center | Englewood | Colorado | 80110 | — |
| Poudre Valley Radiation Oncology | Fort Collins | Colorado | 80528 | — |
| North Suburban Medical Center | Thornton | Colorado | 80229 | — |
| CCOP - Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Washington Cancer Institute at Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Broward General Medical Center Cancer Center | Fort Lauderdale | Florida | 33316 | — |
| University of Florida Shands Cancer Center | Gainesville | Florida | 32610-0232 | — |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Baptist Cancer Institute - Jacksonville | Jacksonville | Florida | 32207 | — |
| Integrated Community Oncology Network at Southside Cancer Center | Jacksonville | Florida | 32207 | — |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | — |
| Baptist Medical Center South | Jacksonville | Florida | 32258 | — |
| Integrated Community Oncology Network | Jacksonville Beach | Florida | 32250 | — |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter | Florida | 33458 | — |
| Baptist-South Miami Regional Cancer Program | Miami | Florida | 33176 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Integrated Community Oncology Network - Orange Park | Orange Park | Florida | 32073 | — |
| M.D. Anderson Cancer Center at Orlando | Orlando | Florida | 32806 | — |
| Florida Cancer Center - Palatka | Palatka | Florida | 32177 | — |
| Sacred Heart Cancer Center at Sacred Heart Hospital | Pensacola | Florida | 32504 | — |
| Flagler Cancer Center | Saint Augustine | Florida | 32086 | — |
| Georgia Cancer Center for Excellence at Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Emory Crawford Long Hospital | Atlanta | Georgia | 30308 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | — |
| Charles B. Eberhart Cancer Center at DeKalb Medical Center | Decatur | Georgia | 30033 | — |
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | — |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise | Idaho | 83712 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637-1470 | — |
| Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| Community Cancer Center | Normal | Illinois | 61761 | — |
| Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | 61554 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF St. Francis Medical Center | Peoria | Illinois | 61637 | — |
| Radiation Oncology Associates Southwest | Fort Wayne | Indiana | 46804 | — |
| Parkview Regional Cancer Center at Parkview Health | Fort Wayne | Indiana | 46805 | — |
| Center for Cancer Care at Goshen General Hospital | Goshen | Indiana | 46526 | — |
| Central Indiana Cancer Centers - East | Indianapolis | Indiana | 46219 | — |
| Community Regional Cancer Care at Community Hospital East | Indianapolis | Indiana | 46219 | — |
| Community Regional Cancer Care at Community Hospital North | Indianapolis | Indiana | 46256 | — |
| Cancer Center at Ball Memorial Hospital | Muncie | Indiana | 47303-3499 | — |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | — |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City | Iowa | 50401 | — |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | 51101 | — |
| Central Baptist Hospital | Lexington | Kentucky | 40503-9985 | — |
| Tulane Cancer Center Office of Clinical Research | Alexandria | Louisiana | 71315-3198 | — |
| Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| St. Agnes Hospital Cancer Center | Baltimore | Maryland | 21229 | — |
| Shore Regional Cancer Center at Memorial Hospital - Easton | Easton | Maryland | 21601 | — |
| Peninsula Regional Medical Center | Salisbury | Maryland | 21801 | — |
| Baystate Regional Cancer Program at D'Amour Center for Cancer Care | Springfield | Massachusetts | 01107 | — |
| Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | 48106-0995 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | — |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | 48236 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007-3731 | — |
| St. Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Mercy Regional Cancer Center at Mercy Hospital | Port Huron | Michigan | 48060 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Minnesota Oncology Hematology, PA - Maplewood | Maplewood | Minnesota | 55109 | — |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | 55422-2900 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| CentraCare Clinic - River Campus | Saint Cloud | Minnesota | 56303 | — |
| Regions Hospital Cancer Care Center | Saint Paul | Minnesota | 55101 | — |
| University of Mississippi Cancer Clinic | Jackson | Mississippi | 39216 | — |
| Regional Cancer Center at Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St Louis | Missouri | 63110 | — |
| Barnes-Jewish West County Hospital | St Louis | Missouri | 63141 | — |
| Billings Clinic - Downtown | Billings | Montana | 59107-7000 | — |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney | Nebraska | 68848-1990 | — |
| Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | 68510 | — |
| Methodist Estabrook Cancer Center | Omaha | Nebraska | 68114 | — |
| CCOP - Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| Renown Institute for Cancer at Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Saint Mary's Regional Medical Center | Reno | Nevada | 89503 | — |
| Payson Center for Cancer Care at Concord Hospital | Concord | New Hampshire | 03301 | — |
| Center for Cancer Care at Exeter Hospital | Exeter | New Hampshire | 03833 | — |
| Elliot Regional Cancer Center at Elliot Hospital | Manchester | New Hampshire | 03103 | — |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton | New Jersey | 08053 | — |
| UMDNJ University Hospital | Newark | New Jersey | 07103 | — |
| J. Phillip Citta Regional Cancer Center at Community Medical Center | Toms River | New Jersey | 08755 | — |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees Township | New Jersey | 08043 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87131-5636 | — |
| New York Oncology Hematology, PC at Albany Regional Cancer Care | Albany | New York | 12206 | — |
| Veterans Affairs Medical Center - Albany | Albany | New York | 12208 | — |
| Sands Cancer Center | Canandaigua | New York | 14424 | — |
| St. Luke's - Roosevelt Hospital Center - St.Luke's Division | New York | New York | 10025 | — |
| Highland Hospital of Rochester | Rochester | New York | 14620 | — |
| University Radiation Oncology at Parkridge Hospital | Rochester | New York | 14626 | — |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University Hospital | Syracuse | New York | 13210 | — |
| Alamance Cancer Center at Alamance Regional Medical Center | Burlington | North Carolina | 27216 | — |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599-7295 | — |
| Blumenthal Cancer Center at Carolinas Medical Center | Charlotte | North Carolina | 28232-2861 | — |
| Presbyterian Cancer Center at Presbyterian Hospital | Charlotte | North Carolina | 28233-3549 | — |
| Kinston Medical Specialists | Kinston | North Carolina | 28501 | — |
| FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst | North Carolina | 28374 | — |
| Cancer Centers of North Carolina - Raleigh | Raleigh | North Carolina | 27607 | — |
| CCOP - MeritCare Hospital | Fargo | North Dakota | 58122 | — |
| Altru Cancer Center at Altru Hospital | Grand Forks | North Dakota | 58201 | — |
| Trinity CancerCare Center | Minot | North Dakota | 58701 | — |
| McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | 44307 | — |
| Summa Center for Cancer Care at Akron City Hospital | Akron | Ohio | 44309-2090 | — |
| Barberton Citizens Hospital | Barberton | Ohio | 44203 | — |
| Aultman Cancer Center at Aultman Hospital | Canton | Ohio | 44710-1799 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Charles M. Barrett Cancer Center at University Hospital | Cincinnati | Ohio | 45267 | — |
| Case Comprehensive Cancer Center | Cleveland | Ohio | 44106-5065 | — |
| Cleveland Clinic Cancer Center at Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| Riverside Methodist Hospital Cancer Care | Columbus | Ohio | 43214-3998 | — |
| Cleveland Clinic Cancer Center | Independence | Ohio | 44131 | — |
| Hillcrest Cancer Center at Hillcrest Hospital | Mayfield Heights | Ohio | 44124 | — |
| Southwest General Health Center | Middleburg Heights | Ohio | 44130 | — |
| UHHS Chagrin Highlands Medical Center | Orange | Ohio | 44122 | — |
| St. Charles Mercy Hospital | Oregon | Ohio | 43616 | — |
| North Coast Cancer Care, Incorporated | Sandusky | Ohio | 44870 | — |
| Flower Hospital Cancer Center | Sylvania | Ohio | 43560 | — |
| St. Anne Mercy Hospital | Toledo | Ohio | 43623 | — |
| UHHS Westlake Medical Center | Westlake | Ohio | 44145 | — |
| Cleveland Clinic - Wooster | Wooster | Ohio | 44691 | — |
| Oklahoma University Cancer Institute | Oklahoma City | Oklahoma | 73104 | — |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | 74136 | — |
| Willamette Valley Cancer Center - Eugene | Eugene | Oregon | 97401 | — |
| Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown | Pennsylvania | 18105 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Geisinger Cancer Institute at Geisinger Health | Danville | Pennsylvania | 17822-0001 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Dale and Frances Hughes Cancer Center at Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| Regional Cancer Center - Erie | Erie | Pennsylvania | 16505 | — |
| Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Cancer Center of Paoli Memorial Hospital | Paoli | Pennsylvania | 19301-1792 | — |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107-5541 | — |
| Fox Chase Cancer Center - Philadelphia | Philadelphia | Pennsylvania | 19111-2497 | — |
| Frankford Hospital Cancer Center - Torresdale Campus | Philadelphia | Pennsylvania | 19114 | — |
| Albert Einstein Cancer Center | Philadelphia | Pennsylvania | 19141 | — |
| McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center | Reading | Pennsylvania | 19612-6052 | — |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Lankenau Cancer Center at Lankenau Hospital | Wynnewood | Pennsylvania | 19096 | — |
| Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Cancer Centers of the Carolinas - Faris Road | Greenville | South Carolina | 29605 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| Cancer Centers of the Carolinas - Seneca | Seneca | South Carolina | 29672 | — |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls | South Dakota | 57117-5039 | — |
| Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | Kingsport | Tennessee | 37662 | — |
| Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| Texas Oncology, PA at Texas Cancer Center - Arlington South | Arlington | Texas | 76014 | — |
| Texas Oncology, PA at Harris Center HEB | Bedford | Texas | 76022 | — |
| Texas Oncology, PA at Texas Cancer Center - Denton South | Denton | Texas | 76210 | — |
| Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital | Fort Worth | Texas | 76104 | — |
| M. D. Anderson Cancer Center at University of Texas | Houston | Texas | 77030-4009 | — |
| Longview Cancer Center | Longview | Texas | 75601 | — |
| West Texas Cancer Center | Odessa | Texas | 79761 | — |
| Cancer Care Centers of South Texas - Northeast | San Antonio | Texas | 78217 | — |
| Texas Oncology, PA at Texas Cancer Center - Sherman | Sherman | Texas | 75090 | — |
| Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land | Sugar Land | Texas | 77479 | — |
| Tyler Cancer Center | Tyler | Texas | 75702 | — |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray | Utah | 84157 | — |
| Utah Valley Regional Medical Center - Provo | Provo | Utah | 84604 | — |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City | Utah | 84106 | — |
| Dixie Regional Medical Center - East Campus | St. George | Utah | 84770 | — |
| Fletcher Allen Health Care - University Health Center Campus | Burlington | Vermont | 05401 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| CCOP - Virginia Mason Research Center | Seattle | Washington | 98101 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Theda Care Cancer Institute | Appleton | Wisconsin | 54911 | — |
| Midelfort Clinic - Luther | Eau Claire | Wisconsin | 54703-1510 | — |
| Luther Midlelfort Hospital | Eau Claire | Wisconsin | 54703 | — |
| Bellin Memorial Hospital | Green Bay | Wisconsin | 54301 | — |
| St. Mary's Hospital Medical Center - Green Bay | Green Bay | Wisconsin | 54303 | — |
| St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | 54307-3508 | — |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse | Wisconsin | 54601 | — |
| Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | — |
| Veterans Affairs Medical Center - Milwaukee | Milwaukee | Wisconsin | 53295 | — |
| D.N. Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| All Saints Cancer Center at Wheaton Franciscan Healthcare | Racine | Wisconsin | 53405 | — |
| Door County Cancer Center at Door County Memorial Hospital | Sturgeon Bay | Wisconsin | 54235-1495 | — |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | 53188 | — |
| Riverview UW Cancer Center at Riverview Hospital | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00533949, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 20, 2022 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00533949 live on ClinicalTrials.gov.