A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT00535782. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Mechanism of Action Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) on Lipids, Arterial Stiffness, and Markers of Atherogenic Risk in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA).
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This 2 arm study will investigate the effects of tocilizumab on lipids, arterial stiffness, and markers of atherogenic risk in patients with moderate to severe active rheumatoid arthritis. In Part 1 of the study, patients will be randomized to receive either tocilizumab 8mg/kg intravenously or placebo every 4 weeks, in combination with methotrexate 7.5-25 mg weekly. In Part 2, all patients will receive open-label treatment with tocilizumab plus methotrexate.
Study identification
- NCT ID
- NCT00535782
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 132 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 31, 2007 (Actual)
- Primary completion
- Sep 30, 2008 (Actual)
- Completion
- Jan 31, 2011 (Actual)
- Last update posted
- Jul 26, 2017
2007 – 2011
United States locations
- U.S. sites
- 26
- U.S. states
- 16
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group; Llc, Central | Anniston | Alabama | 36207 | — |
| Rheumatology Associates of North Alabama | Huntsville | Alabama | 35801 | — |
| Advanced Arthritis Care & Research | Scottsdale | Arizona | 85258 | — |
| Catalina Pointe Clinical Research, Inc. | Tucson | Arizona | 85704 | — |
| Pacific Arthritis Care Center | Los Angeles | California | 90045 | — |
| Arthritis & Rheumatism; Disease Specialities | Aventura | Florida | 33180 | — |
| Science and Research Institute, Inc. | Jupiter | Florida | 33458 | — |
| Arthritis Center Palm Harbor | Palm Harbor | Florida | 34684 | — |
| Arthritis Rsrch of Florida, Inc. | Palm Harbor | Florida | 34684 | — |
| Sarasota Arthritis Center; Research Dept | Sarasota | Florida | 34239 | — |
| Burnette & Silverfield, MDS | Tampa | Florida | 33614 | — |
| Arthritis & Rheumatology of Georgia | Atlanta | Georgia | 30342 | — |
| Deerbrook Medical Associates | Vernon Hills | Illinois | 60061 | — |
| Johns Hopkins Uni | Baltimore | Maryland | 21224 | — |
| Borgess Research Institute | Kalamazoo | Michigan | 49048 | — |
| Jackson Arthritis Clinic | Flowood | Mississippi | 39232 | — |
| Physicians Group, LC DBA Rheumatology & Internal Medicine Associates | St Louis | Missouri | 63131 | — |
| NJP Clinical Research | Clifton | New Jersey | 07012 | — |
| Asheville Arthritis & Osteoporosis Center, PA | Asheville | North Carolina | 28803 | — |
| Health Research of Oklahoma, Llc | Oklahoma City | Oklahoma | 73103 | — |
| Lehigh Valley Hospital; Dept of Medicine | Allentown | Pennsylvania | 18103 | — |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Clinical Research Center of Reading | Wyomissing | Pennsylvania | 19610 | — |
| Houston Inst. For Clinical Research | Houston | Texas | 77074 | — |
| Texas Research Center | Sugar Land | Texas | 77479 | — |
| South Puget Sound Clinical Research | Olympia | Washington | 98502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00535782, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 26, 2017 · Synced Nov 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00535782 live on ClinicalTrials.gov.