Evaluation of M118 in Percutaneous Coronary Intervention (EMINENCE)
Public ClinicalTrials.gov record NCT00543400. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label, Parallel Group Feasibility Study to Determine the Safety and Efficacy of M118 vs. Unfractionated Heparin (UFH) in Subjects With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention (PCI)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective is to evaluate the safety and feasibility of using M118 as an anticoagulant in the target population of subjects with stable coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). The secondary objectives are to evaluate the effect of M118 on procedural indices including procedure success, abrupt closure, post-procedure TIMI flow, and catheter thrombus. Substudy Primary Objective The primary objective of the substudy is to characterize the pharmacokinetic and pharmacodynamic profile of M118 among subjects with stable coronary artery disease undergoing elective PCI.
Study identification
- NCT ID
- NCT00543400
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 503 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 19 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2007 (Type not available)
- Primary completion
- Apr 2009 (Actual)
- Completion
- May 2009 (Actual)
- Last update posted
- Oct 15, 2019
2007 – 2009
United States locations
- U.S. sites
- 37
- U.S. states
- 19
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Arkansas Veterans Healthcare System | Little Rock | Arkansas | 72205 | — |
| Washington Hospital Center, Medstar Research Institute | Washington D.C. | District of Columbia | 20010 | — |
| Jim Moran Heart & Vascular Research Institute | Fort Lauderdale | Florida | 33308 | — |
| Shands Jacksonville Medical Center (UFL) | Jacksonville | Florida | 32209 | — |
| Cardiology Research Associates | Ormond Beach | Florida | 32174 | — |
| Suncoast Cardiovascular Research | St. Petersburg | Florida | 33701 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Advocate Good Shephard Hospital | Barrington | Illinois | 60010 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Trinity Medical Center | Rock Island | Illinois | 61201 | — |
| Midwest Cardiovascular Research Foundation | Davenport | Iowa | 52803 | — |
| University of Kentucky-Gill Heart Institute | Lexington | Kentucky | 40536 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109-5869 | — |
| Henry Ford Hospital Heart & Vascular Institute | Detroit | Michigan | 48202 | — |
| Genesys Regional Medical Center | Grand Blanc | Michigan | 48439 | — |
| Saint Mary's Duluth Clinic Health Center | Duluth | Minnesota | 55805 | — |
| Minneapolis VA Medical Center | Minneapolis | Minnesota | 55417 | — |
| Saint-Luke's Hospital / Mid America Heart Institute | Kansas City | Missouri | 64111 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| UNC Health Systems | Chapel Hill | North Carolina | 27514 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157-1045 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Genesis Health Care System | Zanesville | Ohio | 43701 | — |
| Allegheny Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Black Hills Clinical Research Center | Rapid City | South Dakota | 57701 | — |
| Centennial Heart Cardiovascular Consultants | Nashville | Tennessee | 37203 | — |
| Northwest Texas Healthcare System_Amarillo Heart Clinical Research Institute, Inc. | Amarillo | Texas | 79106 | — |
| Austin Heart, P.A. | Austin | Texas | 78756 | — |
| Plaza Medical Center of Fort Worth | Fort Worth | Texas | 76104 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| Victoria Heart & Vascular Center | Victoria | Texas | 77901 | — |
| Providence Health Center | Waco | Texas | 76712 | — |
| UVA Cardiology, UVA Health System | Charlottesville | Virginia | 22908 | — |
| McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| Comprehensive Cardiology Care | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00543400, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2019 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00543400 live on ClinicalTrials.gov.