A Study of Oseltamivir (Tamiflu) for Treatment of Influenza in Immunocompromised Participants.
Public ClinicalTrials.gov record NCT00545532. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Randomized, Stratified Multi-Center Trial Evaluating Conventional and Double Dose Oseltamivir in the Treatment of Immunocompromised Patients With Influenza
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This 2-arm study will investigate the safety and tolerability of oseltamivir for the treatment of influenza in immunocompromised participants and characterize the effects of oseltamivir in immunocompromised participants on the development of resistant influenza virus. Eligible immunocompromised participants with laboratory-confirmed influenza will be randomized to receive either conventional dose (30 milligrams \[mg\] to 75 mg twice daily orally \[po\], depending on age and weight) or double dose (60 mg-150 mg twice daily po depending on age and weight) olseltamivir for 10 days. Nasal and throat swabs will be taken, and safety evaluations made, at intervals during the study. The anticipated time on study medication is 10 days and the anticipated time on study is 40 days.
Study identification
- NCT ID
- NCT00545532
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 228 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 1 Year and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 4, 2008 (Actual)
- Primary completion
- May 2, 2017 (Actual)
- Completion
- May 2, 2017 (Actual)
- Last update posted
- Jul 12, 2018
2008 – 2017
United States locations
- U.S. sites
- 60
- U.S. states
- 22
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of Alabama At Birmingham; Division of Nephrology | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham; Pediatric Nephrology | Birmingham | Alabama | 35233 | — |
| Pacific Oaks Medical Group | Beverly Hills | California | 90211 | — |
| Providence Clinical Research | Burbank | California | 91505 | — |
| AIDS Research Alliance | Los Angeles | California | 90015 | — |
| UCLA Medical center Medicine/Nephrology | Los Angeles | California | 90095 | — |
| University of California Davis Health System | Sacramento | California | 95817 | — |
| CALIFORNIA PACIFIC MEDICAL CENTER; Office of Dr. Venkat Peddi | San Francisco | California | 94115 | — |
| University of Colorado; Kidney Transplant Center Office of Dr. Laurence Chan | Aurora | Colorado | 80045 | — |
| New England Research Associates | Trumbull | Connecticut | 06611 | — |
| Christiana Care Health System | Newark | Delaware | 19713 | — |
| Omega Research Consultants | Orlando | Florida | 32810 | — |
| Kendall South Medical Center Inc. | South Miami | Florida | 33143 | — |
| All Children'S Hospital; Pediatric Blood & Marrow Transplant Program | St. Petersburg | Florida | 33701 | — |
| Vita Research Solutions, Inc | Tamarac | Florida | 33319 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Piedmont Hospital; Transplant Services | Atlanta | Georgia | 30309 | — |
| EMORY UNIVERSITY; Bone Marrow & Stem Cell Transplant Center | Atlanta | Georgia | 30322 | — |
| Medical College of Georgia; Medicine/ Nephrology | Augusta | Georgia | 30912 | — |
| Northwestern Memorial Hospital; Divison of Infectious Diseases/ Dept of Medicine | Chicago | Illinois | 60611 | — |
| Rush Uni Medical Center; Medicine/ Section of Infectious Diseases | Chicago | Illinois | 60612 | — |
| University of Chicago; Infectious Disease | Chicago | Illinois | 60655 | — |
| Tulane University Medical Center | New Orleans | Louisiana | 70112 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Brigham & Women'S Hospital | Boston | Massachusetts | 02115 | — |
| Western New England Renal & Transplant Associates, P.C. | Springfield | Massachusetts | 01107 | — |
| Uni of Michigan Medical Center; Internal Medicine/ Infectious Disease | Ann Arbor | Michigan | 48109-0378 | — |
| Karmanos Cancer Inst. ; Hudson Webber; Cancer Research Building | Detroit | Michigan | 48201 | — |
| Henry Ford Health System; Gastroenterology | Detroit | Michigan | 48202-2689 | — |
| Wayne State University School of Medicine | Detroit | Michigan | 48210 | — |
| Beals Institute PC | Lansing | Michigan | 48917 | — |
| Washington University; Wash Uni. Sch. Of Med | St Louis | Missouri | 63110 | — |
| Our Lady of Lourdes Medical Center; Transplant Dept | Camden | New Jersey | 08103 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Long Island Jewish/North Shore Hospital | New Hyde Park | New York | 11042 | — |
| Mount Sinai Medical Center; Division of Liver Diseases | New York | New York | 10029 | — |
| DJL Clinical Research PLLC | Charlotte | North Carolina | 28210 | — |
| Novant Health Pulmonary and Critical Care | Matthews | North Carolina | 28105 | — |
| Duke University Health Systems | Raleigh | North Carolina | 27609 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Uni of Cincinnati Medical Center; Nephrology & Hypertension | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic Foundation; Infectious Disease | Cleveland | Ohio | 44195 | — |
| Toledo Hospital | Toledo | Ohio | 43606 | — |
| Nazih Zuhdi Transplant Inst. ; Integris Baptist Medical Center | Oklahoma City | Oklahoma | 73112-4481 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Drexel University; College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| Uni of Pennsylvania; Infectious Diseases | Philadelphia | Pennsylvania | 19104 | — |
| University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | — |
| Children'S Hospital of Pittsburgh; Infectious Disease | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina; Pediatric Cardiology | Charleston | South Carolina | 29425 | — |
| Children'S Medical Center of Dallas | Dallas | Texas | 75235 | — |
| Baylor University Medical Center Transplant Administration | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center; Pediatrics Dept. | Dallas | Texas | 75390 | — |
| Sammons Cancer Center-Baylor University; Blood & Marrow Transplantation | Dallas | Texas | TX 75246 | — |
| The Methodist Hospital | Houston | Texas | 77005 | — |
| M.D Anderson Cancer Center; Infectious Diseases, Infection Control, and Employee Health | Houston | Texas | 77030 | — |
| Texas Tech University Health Sciences Center; Department of Urology | Lubbock | Texas | 79430 | — |
| University of Texas Health Science Center Transplant center | San Antonio | Texas | 78229 | — |
| Scott and White Division of Nephrology Dept of Medicine | Temple | Texas | 76508 | — |
| University of Utah Health Science Center Gastroenterology | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 148 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00545532, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 12, 2018 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00545532 live on ClinicalTrials.gov.