Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study Two
Public ClinicalTrials.gov record NCT00548405. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Rater- and Dose-Blinded Study Comparing Two Annual Cycles of Intravenous Low- and High-Dose Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta 1a (Rebif®) in Patients With Relapsing Remitting Multiple Sclerosis Who Have Relapsed On Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to establish the efficacy and safety of two different doses of alemtuzumab (Lemtrada™) as a treatment for relapsing-remitting multiple sclerosis (MS), in comparison with subcutaneous interferon beta-1a (Rebif®). The study enrolled participants who had received an adequate trial of disease-modifying therapies but experienced at least 1 relapse during prior treatment, and who met a minimum severity of disease as measured by magnetic resonance imaging (MRI). Participants had monthly laboratory tests and comprehensive testing every 3 months.
Study identification
- NCT ID
- NCT00548405
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 840 participants
Conditions and interventions
Conditions
Interventions
- Alemtuzumab 12 mg Biological
- Alemtuzumab 24 mg Biological
- Interferon beta-1a Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2007 (Type not available)
- Primary completion
- Sep 2011 (Actual)
- Completion
- Sep 2011 (Actual)
- Last update posted
- Apr 17, 2017
2007 – 2011
United States locations
- U.S. sites
- 85
- U.S. states
- 34
- U.S. cities
- 74
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Central Neurology Associates, P.C. | Cullman | Alabama | — | — |
| Barrow Neurological Institute, St. Joseph's Hospital and Medical Center | Phoenix | Arizona | — | — |
| Hope Research Institute | Phoenix | Arizona | — | — |
| Mayo Clinic Arizona, Department of Neurology | Scottsdale | Arizona | — | — |
| Northwest NeuroSpecialists, PLLC | Tucson | Arizona | — | — |
| East Bay Physicians Medical Group/Sutter East Bay Medical Foundation | Berkeley | California | — | — |
| Neurology Center of North Orange County | La Habra | California | — | — |
| Department of Neurology, Keck School of Medicine, University of Southern California | Los Angeles | California | — | — |
| Neuro-Therapeutics Inc. | Pasadena | California | — | — |
| Neuro-Therapeutics, Inc | Pasadena | California | — | — |
| University of California, Davis Medical Center | Sacramento | California | — | — |
| Stanford University School of Medicine | Stanford | California | — | — |
| University of Colorado Hospital, Anschutz Outpatient Pavilioin | Aurora | Colorado | — | — |
| Neurological Consultants | Denver | Colorado | — | — |
| Advanced Neurosciences Research | Fort Collins | Colorado | — | — |
| Yale University | New Haven | Connecticut | — | — |
| George Washington University Medical Faculty Associates | Washington D.C. | District of Columbia | — | — |
| University of Florida Neuroscience Institute | Jacksonville | Florida | — | — |
| Neurology Associates, P.A. | Maitland | Florida | — | — |
| Neurological Associates | Pompano Beach | Florida | — | — |
| Negroski, Stein, Sutherland and Hanes Neurology | Sarasota | Florida | — | — |
| Axiom Clinical Research of Florida | Tampa | Florida | — | — |
| University of South Florida, Department of Neurology | Tampa | Florida | — | — |
| Emory University, Department of Neurology | Atlanta | Georgia | — | — |
| Shepherd Center, Inc. | Atlanta | Georgia | — | — |
| Idaho Falls Multiple Sclerosis Center, PLLC | Idaho Falls | Idaho | — | — |
| University of Chicago Medical Center, Department of Neurology | Chicago | Illinois | — | — |
| Consultants in Neurology, Ltd | Northbrook | Illinois | — | — |
| Fort Wayne Neurological Center | Fort Wayne | Indiana | — | — |
| Indiana University School of Medicine, Department of Neurology | Indianapolis | Indiana | — | — |
| Josephson Wallack Munshower Neurology P.C. | Indianapolis | Indiana | — | — |
| Iowa Health Physicians | Des Moines | Iowa | — | — |
| Ruan Neurology Clinic and Research Center | Des Moines | Iowa | — | — |
| University of Kansas Medical Center, Department of Neurology | Kansas City | Kansas | — | — |
| MidAmerica Neuroscience Institute | Lenexa | Kansas | — | — |
| Associates in Neurology, PSC | Lexington | Kentucky | — | — |
| University of Louisville Research Foundation | Louisville | Kentucky | — | — |
| Louisiana State University Health Sciences Center | Shreveport | Louisiana | — | — |
| Caritas St. Elizabeth's Medical Center | Boston | Massachusetts | — | — |
| Partners Multiple Sclerosis Center/Brigham and Women's Hospital | Boston | Massachusetts | — | — |
| Springfield Neurology Associates, LLC | Springfield | Massachusetts | — | — |
| UMass Memorial Medical Center | Worcester | Massachusetts | — | — |
| University of Michigan Department of Neurology | Ann Arbor | Michigan | — | — |
| Henry Ford Hospital | Detroit | Michigan | — | — |
| Wayne State University, School of Medicine, Department of Neurology | Detroit | Michigan | — | — |
| Spectrum Health Medical Group, Neurology (Previously known as Michigan Medical P.C., Neurology) | Grand Rapids | Michigan | — | — |
| Michigan Neurology Associates, P.C. | Saint Clair Shores | Michigan | — | — |
| Northern Michigan Neurology | Traverse City | Michigan | — | — |
| Mayo Clinic Rochester | Rochester | Minnesota | — | — |
| Neurology Consultants of Kansas City, Inc. | Kansas City | Missouri | — | — |
| Montana Neurobehavioral Specialists | Missoula | Montana | — | — |
| University of Nevada School of Medicine | Las Vegas | Nevada | — | — |
| Renown Institute for Neurosciences / Renown regional Medical Center | Reno | Nevada | — | — |
| Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center | Lebanon | New Hampshire | — | — |
| MS Center at Holy Name Hospital | Teaneck | New Jersey | — | — |
| University of New Mexico, Health Sciences Center, MS Specialty Clinic | Albuquerque | New Mexico | — | — |
| Empire Neurology, PC | Latham | New York | — | — |
| Winthrop University Hospital, Clinical Trials Center | Mineola | New York | — | — |
| Mount Sinai School of Medicine, Corinne Goldsmith Dickinson Center for Multiple Sclerosis | New York | New York | — | — |
| Comprehensive Multiple Sclerosis Care Center at South Shore Neurologic Associates, P.C. | Patchogue | New York | — | — |
| University of Rochester Medical Center | Rochester | New York | — | — |
| SUNY Upstate Medical University, Department of Neurology | Syracuse | New York | — | — |
| University of North Carolina-Chapel Hill, Department of Neurology | Chapel Hill | North Carolina | — | — |
| Wake Forest University Health Science, Department of Neurology | Winston-Salem | North Carolina | — | — |
| Cleveland Clinic Foundation, Mellen Center | Cleveland | Ohio | — | — |
| Neurology Specialists, Inc. | Dayton | Ohio | — | — |
| Oak Clinic for Multiple Sclerosis | Uniontown | Ohio | — | — |
| MS Center of Oklahoma | Oklahoma City | Oklahoma | — | — |
| Lehigh Valley Hospital, Neuroscience and Pain Research | Allentown | Pennsylvania | — | — |
| Northshore Clinical Associates | Erie | Pennsylvania | — | — |
| University of Pittsburgh, Kaufmann Medical Building | Pittsburgh | Pennsylvania | — | — |
| The Neurology Foundation, Inc. | Providence | Rhode Island | — | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | — | — |
| Advanced Neurosciences Institute | Franklin | Tennessee | — | — |
| Biomedical Research Alliance of NY, LLC | Franklin | Tennessee | — | — |
| Hope Neurology PC | Knoxville | Tennessee | — | — |
| Vanderbilt Multiple Sclerosis Center | Nashville | Tennessee | — | — |
| Clinical Center for Multiple Sclerosis | Dallas | Texas | — | — |
| Central Texas Neurology | Round Rock | Texas | — | — |
| Integra Clinical Research | San Antonio | Texas | — | — |
| Neurology Center of San Antonio | San Antonio | Texas | — | — |
| MS Center of Greater Washington, P.C. | Vienna | Virginia | — | — |
| Swedish Neuroscience Institute | Seattle | Washington | — | — |
| Virginia Mason Medical Center | Seattle | Washington | — | — |
| Rockwood Clinical Research Center | Spokane | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 106 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00548405, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 17, 2017 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00548405 live on ClinicalTrials.gov.