Independent directory Public ClinicalTrials.gov records United States
ClinicalTrials.gov record
Completed Phase 3 Interventional Results available

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

ClinicalTrials.gov ID: NCT00566852

Public ClinicalTrials.gov record NCT00566852. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 29, 2026, 12:31 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

RATIONALE: Memantine may be able to decrease side effects caused by whole-brain radiation therapy. It is not yet known if memantine is effective in preventing side effects caused by whole-brain radiation therapy. PURPOSE: This randomized phase III trial is studying memantine to see how well it works compared to a placebo in preventing side effects caused by whole-brain radiation therapy in patients with brain metastases from solid tumors.

Study identification

NCT ID
NCT00566852
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Enrollment
554 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years to 120 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 2008 (Type not available)
Primary completion
Apr 2011 (Actual)
Completion
Dec 2016 (Actual)
Last update posted
Aug 21, 2017

2008 – 2016

United States locations

U.S. sites
229
U.S. states
42
U.S. cities
186
Facility City State ZIP Site status
MBCCOP - Gulf Coast Mobile Alabama 36604 —
Providence Cancer Center at Providence Hospital Mobile Alabama 36608 —
Arizona Oncology Services Foundation Phoenix Arizona 85013 —
Mayo Clinic Scottsdale Scottsdale Arizona 85259-5499 —
Arizona Oncology - Tucson Tucson Arizona 85704 —
Arizona Cancer Center at University of Arizona Health Sciences Center Tucson Arizona 85724-5024 —
Auburn Radiation Oncology Auburn California 95603 —
Providence Saint Joseph Medical Center - Burbank Burbank California 91505 —
Radiation Oncology Centers - Cameron Park Cameron Park California 95682 —
Mercy Cancer Center at Mercy San Juan Medical Center Carmichael California 95608 —
Enloe Cancer Center at Enloe Medical Center Chico California 95926 —
Cancer Care Center at John Muir Health - Concord Campus Concord California 94524-4110 —
City of Hope Comprehensive Cancer Center Duarte California 91010-3000 —
Glendale Adventist Medical Center Glendale California 91206 —
Rebecca and John Moores UCSD Cancer Center La Jolla California 92093-0658 —
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center Los Angeles California 90048 —
USC/Norris Comprehensive Cancer Center and Hospital Los Angeles California 90089-9181 —
St. Joseph Hospital Regional Cancer Center - Orange Orange California 92868 —
Radiation Oncology Center - Roseville Roseville California 95661 —
Radiological Associates of Sacramento Medical Group, Incorporated Sacramento California 95815 —
University of California Davis Cancer Center Sacramento California 95817 —
Mercy General Hospital Sacramento California 95819 —
Stanford Cancer Center Stanford California 94305-5824 —
Emanuel Regional Cancer Services at Emanuel Medical Center Turlock California 95382 —
Solano Radiation Oncology Center Vacaville California 95687 —
John Muir/Mt. Diablo Comprehensive Cancer Center Walnut Creek California 94598 —
Rocky Mountain Cancer Centers - Aurora Aurora Colorado 80012 —
Rocky Mountain Cancer Centers - Colorado Springs Colorado Springs Colorado 80909 —
Poudre Valley Radiation Oncology Fort Collins Colorado 80528 —
Yale Cancer Center New Haven Connecticut 06520-8028 —
CCOP - Christiana Care Health Services Newark Delaware 19713 —
Washington Cancer Institute at Washington Hospital Center Washington D.C. District of Columbia 20010 —
University of Florida Shands Cancer Center Gainesville Florida 32610-0232 —
Baptist Cancer Institute - Jacksonville Jacksonville Florida 32207 —
Integrated Community Oncology Network at Southside Cancer Center Jacksonville Florida 32207 —
Baptist Medical Center South Jacksonville Florida 32258 —
Integrated Community Oncology Network Jacksonville Beach Florida 32250 —
Integrated Community Oncology Network - Orange Park Orange Park Florida 32073 —
Florida Institute of Research, Medicine and Surgery Cancer Center Orlando Florida 32806 —
Florida Cancer Center - Palatka Palatka Florida 32177 —
Flagler Cancer Center Saint Augustine Florida 32086 —
Winship Cancer Institute of Emory University Atlanta Georgia 30322 —
John B. Amos Cancer Center Columbus Georgia 31904 —
Veterans Affairs Medical Center - Atlanta (Decatur) Decatur Georgia 30033 —
Northeast Georgia Medical Center Gainesville Georgia 30501 —
Northwest Community Hospital Arlington Heights Illinois 60005 —
John H. Stroger, Jr. Hospital of Cook County Chicago Illinois 60612-3785 —
Cancer Institute at St. John's Hospital Springfield Illinois 62702 —
CCOP - Carle Cancer Center Urbana Illinois 61801 —
Saint John's Cancer Center at Saint John's Medical Center Anderson Indiana 46016 —
Bloomington Hospital Regional Cancer Institute Bloomington Indiana 47403 —
Radiation Oncology Associates Southwest Fort Wayne Indiana 46804 —
Parkview Regional Cancer Center at Parkview Health Fort Wayne Indiana 46805 —
Center for Cancer Care at Goshen General Hospital Goshen Indiana 46526 —
Indiana University Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202-5289 —
Methodist Cancer Center at Methodist Hospital Indianapolis Indiana 46202 —
Central Indiana Cancer Centers - East Indianapolis Indiana 46219 —
Community Regional Cancer Care at Community Hospital East Indianapolis Indiana 46219 —
Community Regional Cancer Care at Community Hospital North Indianapolis Indiana 46256 —
Cancer Center at Ball Memorial Hospital Muncie Indiana 47303-3499 —
CCOP - Northern Indiana CR Consortium South Bend Indiana 46601 —
Holden Comprehensive Cancer Center at University of Iowa Iowa City Iowa 52242-1002 —
Kansas City Cancer Centers - Southwest Overland Park Kansas 66210 —
Lucille P. Markey Cancer Center at University of Kentucky Lexington Kentucky 40536-0093 —
Norton Suburban Hospital Louisville Kentucky 40207 —
Greenebaum Cancer Center at University of Maryland Medical Center Baltimore Maryland 21201 —
St. Agnes Hospital Cancer Center Baltimore Maryland 21229 —
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center Baltimore Maryland 21237 —
Good Samaritan Hospital of Maryland Baltimore Maryland 21239 —
Central Maryland Oncology Center Columbia Maryland 21044 —
Tate Cancer Center at Baltimore Washington Medical Center Glen Burnie Maryland 21061 —
Cancer Institute at St. Joseph Medical Center Towson Maryland 21204 —
Boston University Cancer Research Center Boston Massachusetts 02118 —
Charach Cancer Center at Huron Valley - Sinai Hospital Commerce Michigan 48382 —
Barbara Ann Karmanos Cancer Institute Detroit Michigan 48201-1379 —
Josephine Ford Cancer Center at Henry Ford Hospital Detroit Michigan 48202 —
Great Lakes Cancer Institute at McLaren Regional Medical Center Flint Michigan 48532 —
CCOP - Grand Rapids Grand Rapids Michigan 49503 —
St. Mary Mercy Hospital Livonia Michigan 48154 —
William Beaumont Hospital - Royal Oak Campus Royal Oak Michigan 48073 —
Albert Lea Cancer Center at Albert Lea Medical Center Albert Lea Minnesota 56007 —
Fairview Ridges Hospital Burnsville Minnesota 55337 —
Mercy and Unity Cancer Center at Mercy Hospital Coon Rapids Minnesota 55433 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Mercy and Unity Cancer Center at Unity Hospital Fridley Minnesota 55432 —
Immanuel St. Joseph's Mankato Minnesota 56002 —
Minnesota Oncology Hematology, PA - Maplewood Maplewood Minnesota 55109 —
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital Minneapolis Minnesota 55407 —
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center Robbinsdale Minnesota 55422-2900 —
Mayo Clinic Cancer Center Rochester Minnesota 55905 —
CentraCare Clinic - River Campus Saint Cloud Minnesota 56303 —
CCOP - Metro-Minnesota Saint Louis Park Minnesota 55416 —
United Hospital Saint Paul Minnesota 55102 —
Ridgeview Medical Center Waconia Minnesota 55387 —
Regional Cancer Center at Singing River Hospital Pascagoula Mississippi 39581 —
Kansas City Cancer Centers - South Kansas City Missouri 64131 —
Kansas City Cancer Centers - North Kansas City Missouri 64154 —
Hulston Cancer Center at Cox Medical Center South Springfield Missouri 65807 —
CCOP - St. Louis-Cape Girardeau St Louis Missouri 63141 —
CCOP - Montana Cancer Consortium Billings Montana 59101 —
Northern Rockies Radiation Oncology Center Billings Montana 59101 —
Billings Clinic - Downtown Billings Montana 59107-7000 —
Methodist Estabrook Cancer Center Omaha Nebraska 68114 —
Nebraska Medical Center Omaha Nebraska 68198 —
CCOP - Nevada Cancer Research Foundation Las Vegas Nevada 89106 —
Renown Institute for Cancer at Renown Regional Medical Center Reno Nevada 89502 —
Payson Center for Cancer Care at Concord Hospital Concord New Hampshire 03301 —
Elliot Regional Cancer Center at Elliot Hospital Manchester New Hampshire 03103 —
Ocean Medical Center at Meridian Health Brick New Jersey 08724 —
Cancer Institute of New Jersey at Cooper University Hospital - Camden Camden New Jersey 08103 —
Trinitas Comprehensive Cancer Center at Trinitas Hospital Elizabeth New Jersey 07207 —
Princeton Radiation Oncology Center Jamesburg New Jersey 08831 —
Saint Peter's University Hospital New Brunswick New Jersey 08901 —
University Medical Center at Princeton Princeton New Jersey 08540-3298 —
J. Phillip Citta Regional Cancer Center at Community Medical Center Toms River New Jersey 08755 —
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees Township New Jersey 08043 —
Lovelace Medical Center - Downtown Albuquerque New Mexico 87102 —
Radiation Oncology Associates, PA Albuquerque New Mexico 87109 —
University of New Mexico Cancer Center Albuquerque New Mexico 87131-5636 —
New York Oncology Hematology, PC at Albany Regional Cancer Care Albany New York 12206 —
Veterans Affairs Medical Center - Albany Albany New York 12208 —
New York Methodist Hospital Brooklyn New York 11215 —
Roswell Park Cancer Institute Buffalo New York 14263-0001 —
Sands Cancer Center Canandaigua New York 14424 —
CCOP - North Shore University Hospital Manhasset New York 11030 —
Long Island Jewish Medical Center New Hyde Park New York 11040 —
Highland Hospital of Rochester Rochester New York 14620 —
Lipson Cancer and Blood Center at Rochester General Hospital Rochester New York 14621 —
University Radiation Oncology at Parkridge Hospital Rochester New York 14626 —
James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester New York 14642 —
Mission Hospitals - Memorial Campus Asheville North Carolina 28801 —
New Hanover Radiation Oncology, PA Wilmington North Carolina 28401 —
Trinity CancerCare Center Minot North Dakota 58701 —
McDowell Cancer Center at Akron General Medical Center Akron Ohio 44307 —
Summa Center for Cancer Care at Akron City Hospital Akron Ohio 44309-2090 —
Barberton Citizens Hospital Barberton Ohio 44203 —
Charles M. Barrett Cancer Center at University Hospital Cincinnati Ohio 45267 —
Cleveland Clinic Cancer Center at Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Taussig Cancer Center Cleveland Ohio 44195 —
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Columbus Ohio 43210-1240 —
Cleveland Clinic Cancer Center Independence Ohio 44131 —
Northwest Ohio Oncology Center Maumee Ohio 43537-1839 —
Hillcrest Cancer Center at Hillcrest Hospital Mayfield Heights Ohio 44124 —
St. Charles Mercy Hospital Oregon Ohio 43616 —
Cancer Care Center, Incorporated Salem Ohio 44460 —
North Coast Cancer Care, Incorporated Sandusky Ohio 44870 —
Flower Hospital Cancer Center Sylvania Ohio 43560 —
Medical University of Ohio Cancer Center Toledo Ohio 43614 —
CCOP - Toledo Community Hospital Toledo Ohio 43617 —
St. Anne Mercy Hospital Toledo Ohio 43623 —
Precision Radiotherapy at University Pointe West Chester Ohio 45069 —
Cancer Treatment Center Wooster Ohio 44691 —
Cleveland Clinic - Wooster Wooster Ohio 44691 —
Oklahoma University Cancer Institute Oklahoma City Oklahoma 73104 —
Willamette Valley Cancer Center - Eugene Eugene Oregon 97401 —
Three Rivers Community Hospital Grants Pass Oregon 97527 —
Dubs Cancer Center at Rogue Valley Medical Center Medford Oregon 97504 —
Providence Cancer Center at PMCC Medford Oregon 97504 —
Rosenfeld Cancer Center at Abington Memorial Hospital Abington Pennsylvania 19001 —
UPMC Cancer Center at Beaver Medical Center Beaver Pennsylvania 15009 —
St. Luke's Cancer Network at St. Luke's Hospital Bethlehem Pennsylvania 18015 —
Bryn Mawr Hospital Bryn Mawr Pennsylvania 19010 —
UPMC Cancer Center at Jefferson Regional Medical Center Clairton Pennsylvania 15025 —
Cancer Center at Clarion Hospital Clarion Pennsylvania 16214 —
Geisinger Cancer Institute at Geisinger Health Danville Pennsylvania 17822-0001 —
Delaware County Regional Cancer Center at Delaware County Memorial Hospital Drexel Hill Pennsylvania 19026 —
Northeast Radiation Oncology Center Dunmore Pennsylvania 18512 —
Adams Cancer Center Gettysburg Pennsylvania 17325 —
UPMC Cancer Center - Arnold Palmer Pavilion Greensburg Pennsylvania 15601 —
Cherry Tree Cancer Center Hanover Pennsylvania 17331 —
Penn State Cancer Institute at Milton S. Hershey Medical Center Hershey Pennsylvania 17033-0850 —
UPMC Cancer Center at the John P. Murtha Pavilion Johnstown Pennsylvania 15901 —
UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania 15132 —
UPMC - Moon Moon Township Pennsylvania 15108 —
UPMC Cancer Center - Natrona Heights Natrona Heights Pennsylvania 15065 —
Jameson Memorial Hospital - North Campus New Castle Pennsylvania 16105 —
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Philadelphia Pennsylvania 19107-5541 —
Fox Chase Cancer Center - Philadelphia Philadelphia Pennsylvania 19111-2497 —
Albert Einstein Cancer Center Philadelphia Pennsylvania 19141 —
UPMC - Shadyside Pittsburgh Pennsylvania 15213-2582 —
UPMC Cancer Center at Magee-Womens Hospital Pittsburgh Pennsylvania 15213 —
UPMC Cancer Center at UPMC St. Margaret Pittsburgh Pennsylvania 15215 —
UPMC Cancer Center at UPMC Passavant Pittsburgh Pennsylvania 15237 —
UPMC Cancer Center - Upper St. Clair Pittsburgh Pennsylvania 15243 —
UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania 16346 —
UPMC Cancer Center - Uniontown Uniontown Pennsylvania 15401 —
Washington Hospital Cancer Center Washington Pennsylvania 15301 —
Lankenau Cancer Center at Lankenau Hospital Wynnewood Pennsylvania 19096 —
York Cancer Center at Apple Hill Medical Center York Pennsylvania 17405 —
Hollings Cancer Center at Medical University of South Carolina Charleston South Carolina 29425 —
CCOP - Upstate Carolina Spartanburg South Carolina 29303 —
Rapid City Regional Hospital Rapid City South Dakota 57701 —
Texas Oncology, PA at Texas Cancer Center - Arlington South Arlington Texas 76014 —
Texas Oncology, PA at Harris Center HEB Bedford Texas 76022 —
Medical City Dallas Hospital Dallas Texas 75230 —
Texas Oncology, PA at Texas Cancer Center Dallas Southwest Dallas Texas 75237 —
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas Texas 75390 —
Texas Oncology, PA at Texas Cancer Center - Denton South Denton Texas 76210 —
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital Fort Worth Texas 76104 —
Longview Cancer Center Longview Texas 75601 —
West Texas Cancer Center Odessa Texas 79761 —
Cancer Care Centers of South Texas - Northeast San Antonio Texas 78217 —
University of Texas Health Science Center at San Antonio San Antonio Texas 78229-3900 —
Texas Oncology, PA at Texas Cancer Center - Sherman Sherman Texas 75090 —
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land Sugar Land Texas 77479 —
Tyler Cancer Center Tyler Texas 75702 —
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center Murray Utah 84157 —
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center Ogden Utah 84403 —
Utah Cancer Specialists at UCS Cancer Center Salt Lake City Utah 84106 —
Huntsman Cancer Institute at University of Utah Salt Lake City Utah 84112 —
Dixie Regional Medical Center - East Campus St. George Utah 84770 —
Fletcher Allen Health Care - University Health Center Campus Burlington Vermont 05401 —
University of Virginia Cancer Center Charlottesville Virginia 22908 —
Sentara Cancer Institute at Sentara Norfolk General Hospital Norfolk Virginia 23507 —
CCOP - Virginia Mason Research Center Seattle Washington 98101 —
Cancer Care Northwest - Spokane South Spokane Washington 99202 —
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington 98902 —
Schiffler Cancer Center at Wheeling Hospital Wheeling West Virginia 26003 —
Theda Care Cancer Institute Appleton Wisconsin 54911 —
St. Vincent Hospital Regional Cancer Center Green Bay Wisconsin 54307-3508 —
Franciscan Skemp Healthcare - La Crosse Campus La Crosse Wisconsin 54601 —
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison Wisconsin 53792-6164 —
Bay Area Cancer Care Center at Bay Area Medical Center Marinette Wisconsin 54143 —
Community Memorial Hospital Cancer Care Center Menomonee Falls Wisconsin 53051 —
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center Milwaukee Wisconsin 53215 —
Medical College of Wisconsin Cancer Center Milwaukee Wisconsin 53226 —
All Saints Cancer Center at Wheaton Franciscan Healthcare Racine Wisconsin 53405 —
University of Wisconcin Cancer Center at Aspirus Wausau Hospital Wausau Wisconsin 54401 —
West Allis Memorial Hospital West Allis Wisconsin 53227 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00566852, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 21, 2017 · Synced Oct 29, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00566852 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →