ClinicalTrials.gov record
Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier)
ClinicalTrials.gov ID: NCT00575055
Public ClinicalTrials.gov record NCT00575055. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Trial of Bapineuzumab (AAB-001, ELN115727) In Patients With Mild to Moderate Alzheimer's Disease Who Are Apolipoprotein E4 Carriers.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, double-blind, placebo controlled, randomized, outpatient, multiple dose study in male and female patients ages 50 to less than 89 years with mild to moderate AD. Approximately 200 study sites in the US and Canada will be involved. Patients will be randomized to receive either bapineuzumab or placebo. Each patient's participation will last approximately 1.5 years. Bapineuzumab is a humanized monoclonal antibody, which binds to and clears beta amyloid peptide, and is designed to provide antibodies to beta amyloid directly to the patient.
Study identification
- NCT ID
- NCT00575055
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,121 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 88 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2007 (Type not available)
- Primary completion
- Apr 2012 (Actual)
- Completion
- Apr 2012 (Actual)
- Last update posted
- Nov 25, 2013
2007 – 2012
United States locations
- U.S. sites
- 186
- U.S. states
- 43
- U.S. cities
- 146
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Hospital (UAB) | Birmingham | Alabama | 35205 | — |
| Dedicated Clinical Research, Inc. | Goodyear | Arizona | 85395 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| HOPE Research Institute, LLC | Phoenix | Arizona | 85050 | — |
| Banner Research Institute | Sun City | Arizona | 85351 | — |
| University of Arizona College of Medicine, Health Sciences Center | Tucson | Arizona | 85724 | — |
| Northwest NeuroSpecialists, PLLC | Tucson | Arizona | 85741 | — |
| Clinical Trials Inc. | Little Rock | Arkansas | 72205 | — |
| East Bay Physicians Medical Group | Berkeley | California | 94705 | — |
| AVI Clinical Research | Carson | California | 90746 | — |
| ATP Clinical Research, Inc | Costa Mesa | California | 92626 | — |
| Pharmacology Research Institute | Encino | California | 91316 | — |
| Margolin Brain Institute | Fresno | California | 93720 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Coordinated Clinical Research | La Jolla | California | 92037 | — |
| University of California San Diego | La Jolla | California | 92037 | — |
| Senior Clinical Trials, Inc | Laguna Hills | California | 92653 | — |
| Collaborative NeuroScience Network, Inc. | Long Beach | California | 90806 | — |
| Pharmacology Research Institute | Los Alamitos | California | 90720 | — |
| Vintage Institute for Clinical Research, Inc | Los Angeles | California | 90035 | — |
| UCLA Department of Neurology | Los Angeles | California | 90095 | — |
| Pharmacology Research Institute | Newport Beach | California | 92660 | — |
| Neurology Center | Oceanside | California | 92056 | — |
| University of California Irvine Medical Center | Orange | California | 92868 | — |
| Neuro-Therapeutics Inc. | Pasadena | California | 91105 | — |
| Sutter Neuroscience Medical Group | Sacramento | California | 95816 | — |
| University of California Davis Alzheimer's Disease Research Center | Sacramento | California | 95817 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92123 | — |
| Sharp Mesa Vista Hospital | San Diego | California | 92123 | — |
| San Francisco Clinical Research Center | San Francisco | California | 94109 | — |
| University of California at San Francisco Medical Center at Parnassus | San Francisco | California | 94117 | — |
| Neurological Research Institute | Santa Monica | California | 90404 | — |
| Schuster Medical Research Institute | Sherman Oaks | California | 91403 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Alpine Clinical Research Center | Boulder | Colorado | 80304 | — |
| Mile High Research Center | Denver | Colorado | 80218 | — |
| Advanced Neurosciences Research, LLC | Fort Collins | Colorado | 80528 | — |
| Associated Neurologists, PC | Danbury | Connecticut | 06810 | — |
| Associated Neurologists of Southern CT, P.C. | Fairfield | Connecticut | 06824 | — |
| Institute for Neurodegenerative Disorders | New Haven | Connecticut | 06510 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Research Center for Clinical Studies, Inc | Norwalk | Connecticut | 06851 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20057 | — |
| JEM Research, LLC | Atlantis | Florida | 33462 | — |
| Bradenton Research Center, Inc | Bradenton | Florida | 34205 | — |
| Quantum Laboratories, Inc. | Deerfield Beach | Florida | 33064 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neurologic Consultants, P.A. | Fort Lauderdale | Florida | 33308 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Clinical Physiology Associates, Inc. | Fort Myers | Florida | 33916 | — |
| Emerald Coast Mood & Memory, PA. | Fort Walton Beach | Florida | 32547 | — |
| MD Clinical | Hallandale | Florida | 33009 | — |
| Mayo Clinic College of Medicine | Jacksonville | Florida | 32224 | — |
| Neurology Associates | Maitland | Florida | 32751 | — |
| Melbourne Internal Medicine Associates, MIMA | Melbourne | Florida | 32901 | — |
| Pharmax Research Clinic, LLC | Miami | Florida | 33126 | — |
| Miami Jewish Health Systems | Miami | Florida | 33137 | — |
| Allied Clinical Trials, Inc. | Miami | Florida | 33156 | — |
| Renstar Medical Research | Ocala | Florida | 34471 | — |
| Compass Research, LLC | Orlando | Florida | 32806 | — |
| Palm Beach Neurological Center/Advanced Research Consultants | Palm Beach Gardens | Florida | 33418 | — |
| Neurostudies, Inc | Port Charlotte | Florida | 33952 | — |
| The Roskamp Institute, Inc | Sarasota | Florida | 34243 | — |
| Miami Research Associates | South Miami | Florida | 33143 | — |
| Meridien Research | St. Petersburg | Florida | 33709 | — |
| Suncoast Neuroscience Associates, Inc. | St. Petersburg | Florida | 33713 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute | Tampa | Florida | 33613 | — |
| Stedman Clinical Trials, LLC | Tampa | Florida | 33613 | — |
| University of South Florida Suncoast Alzheimer's and Gerontology Center | Tampa | Florida | 33613 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Emory University, School of Medicine | Atlanta | Georgia | 30322 | — |
| Multiple Sclerosis Center of Atlanta | Atlanta | Georgia | 30327 | — |
| NeuroTrials Research, Inc. | Atlanta | Georgia | 30342 | — |
| Medical Research and Health Educational Foundation, Inc | Columbus | Georgia | 31909 | — |
| DeKalb Neurology Associates, LLC | Decatur | Georgia | 30033 | — |
| Gwinnett Medical Center | Lawrenceville | Georgia | 30045 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Alexian Brothers Neurosciences Institute | Elk Grove Village | Illinois | 60007 | — |
| Southern Illinois University, School of Medicine | Springfield | Illinois | 62794 | — |
| Elkhart Clinic, LLC | Elkhart | Indiana | 46514 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Mid America Neuroscience Institute | Lenexa | Kansas | 66214 | — |
| Associates in Neurology, PSC | Lexington | Kentucky | 40513 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Four Rivers Clinical Research, Inc | Paducah | Kentucky | 42003 | — |
| Lake Charles Clinical Trials | Lake Charles | Louisiana | 70629 | — |
| Louisiana State University Health Sciences Center | Shreveport | Louisiana | 70112 | — |
| J. Gary Booker, MD, APMC | Shreveport | Louisiana | 71104 | — |
| Maine Medical Partners Neurology | Scarborough | Maine | 04074 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21224 | — |
| McLean Hospital | Belmont | Massachusetts | 02478 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| ActivMed Practices and Research, Inc | Haverhill | Massachusetts | 01830 | — |
| Neurocare, Inc | Newton | Massachusetts | 02459 | — |
| Neuroscience Research of the Berkshires | Pittsfield | Massachusetts | 01201 | — |
| Donald S. Marks, MD, P.C. | Plymouth | Massachusetts | 02360 | — |
| Springfield Neurology Associates | Springfield | Massachusetts | 01104 | — |
| University of Michigan | Ann Arbor | Michigan | 48105 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Michigan State University | East Lansing | Michigan | 48824 | — |
| Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| Borgess Medical Center/Borgess Research Institute | Kalamazoo | Michigan | 49048 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Saint Luke's Hospital, Mid America Brain and Stroke Institute | Kansas City | Missouri | 64111 | — |
| The Center for Pharmaceutical Research | Kansas City | Missouri | 64114 | — |
| St. Louis University School of Medicine | St Louis | Missouri | 63104 | — |
| Washington University School of Medicine | St Louis | Missouri | 63108 | — |
| Deaconess Billings Clinical Research Center | Billings | Montana | 59101 | — |
| Advanced Neurology Specialists | Great Falls | Montana | 59405 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-2045 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| Memory Enhancement Center of America, Inc. | Eatontown | New Jersey | 07724 | — |
| The NeuroCognitive Institute | Mount Arlington | New Jersey | 07856 | — |
| Alzheimer's Research Corporation (ARC) | Paterson | New Jersey | 08759 | — |
| Princeton Medical Institute | Princeton | New Jersey | 08540 | — |
| University of Medicine and Dentistry of New Jersey | Stratford | New Jersey | 08084 | — |
| Albuquerque Neuroscience, Inc. | Albuquerque | New Mexico | 87109 | — |
| Upstate Clinical Research, LLC | Albany | New York | 12205 | — |
| Neurological Associates Albany PC | Albany | New York | 12208 | — |
| Neuroscience Research Center at Albany Medical Center | Albany | New York | 12208 | — |
| Five Towns Neuroscience Research | Cedarhurst | New York | 11516 | — |
| Advanced BioBehavioral Sciences | Elmsford | New York | 10523 | — |
| Empire Neurology, PC | Latham | New York | 12110 | — |
| Neurological Care of CNY | Liverpool | New York | 13088 | — |
| Parker Jewish Institute for Health Care & Rehabilitation | New Hyde Park | New York | 11040 | — |
| NYU School of Medicine/Psychiatry | New York | New York | 10016 | — |
| Mt. Sinai School of Medicine | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Nathan S. Kline Institute for Psychiatric Research | Orangeburg | New York | 10962 | — |
| University of Rochester Medical Center @ Monroe Community Hospital | Rochester | New York | 14620 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Clinical Trials of America, Inc | Hickory | North Carolina | 28601 | — |
| New Hope Clinical Research | Hickory | North Carolina | 28601 | — |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| University Hospitals of Cleveland, Case Medical Center, Memory and Cognition Center | Beachwood | Ohio | 44122 | — |
| Neuro-Behavioral Clinical Research, Inc | Canton | Ohio | 44718 | — |
| NeuroCare Center, Inc | Canton | Ohio | 44718 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| Neurology Specialists, Inc. | Dayton | Ohio | 45417 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Red River Medical Research Center, LLC | Oklahoma City | Oklahoma | 73112 | — |
| Providence Medical Group-Medford Neurology | Medford | Oregon | 97504 | — |
| Summit Research Group, LLC | Portland | Oregon | 97210 | — |
| Providence Health Service System, AD Center, Brain Institute | Portland | Oregon | 97225 | — |
| Oregon Health & Sciences University | Portland | Oregon | 97239 | — |
| Abington Neurological Assoc | Abington | Pennsylvania | 19001 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| Penn Memory Center | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson Hospital for Neuroscience | Philadelphia | Pennsylvania | 19107 | — |
| Clinical Trials Research Services, LLC | Pittsburgh | Pennsylvania | 15206 | — |
| University of Virginia | Pittsburgh | Pennsylvania | 15213 | — |
| Universtiy of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Rhode Island Mood and Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Medical University of South Carolina | North Charleston | South Carolina | 29406 | — |
| Avera Research Institute | Sioux Falls | South Dakota | 57105 | — |
| Neurology Clinic, PC | Cordova | Tennessee | 38018 | — |
| Psychiatric Consultants, PC | Franklin | Tennessee | 37067 | — |
| East Tennessee State University | Johnson City | Tennessee | 37614-1707 | — |
| Volunteer Research Group | Knoxville | Tennessee | 37920 | — |
| Texas Neurology, PA | Dallas | Texas | 75214 | — |
| University of North Texas/Health Sciences Center-Fort Worth | Fort Worth | Texas | 76106 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Innovative Clinical Trials | San Antonio | Texas | 78229 | — |
| Integra Clinical Research, LLC | San Antonio | Texas | 78231 | — |
| Wasatch Clinical Research | Salt Lake City | Utah | 84107 | — |
| University of Utah, Dept. of Neurology | Salt Lake City | Utah | 84108 | — |
| The Memory Clinic | Bennington | Vermont | 05201 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| Innovative Clinical Research Center | Alexandria | Virginia | 22304 | — |
| Alliance Research Group, LLC | Richmond | Virginia | 23230 | — |
| University of Washington Veterans Affairs | Seattle | Washington | 98108 | — |
| Pacific Medical Centers | Seattle | Washington | 98144 | — |
| University of Wisconsin School of Medicine and Public Health | Madison | Wisconsin | 53705 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00575055, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 25, 2013 · Synced Nov 2, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00575055 live on ClinicalTrials.gov.