ClinicalTrials.gov record

Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

PET Study Examining the Dopaminergic Activity of Armodafinil in Adults

ClinicalTrials.gov ID: NCT00592943

Public ClinicalTrials.gov record NCT00592943. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Nov 11, 2026, 9:33 AM EST

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Official title

A PET Study Examining the Dopaminergic Activity of Armodafinil in Adults

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The specific aims of this study are 1) to document the Dopamine Transporter (DAT) receptor occupancy of armodafinil using positron emission tomography (PET) scanning with C-11 altropane as the ligand and 2) to document the increased intrasynaptic dopamine produced by armodafinil using PET scanning with C-11 raclopride as the ligand. We hypothesize that DAT occupancy will be low with armodafinil; less than the DAT occupancy produced by therapeutic doses of methylphenidate. We also hypothesize that increases in intrasynaptic dopamine will be relatively low with armodafinil.

Study identification

NCT ID: NCT00592943
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Massachusetts General Hospital; Other
Enrollment: 12 participants

Conditions and interventions

Conditions

Healthy

Interventions

armodafinil Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 35 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 2007 (Type not available)
Primary completion: May 2008 (Actual)
Completion: May 2010 (Actual)
Last update posted: Nov 13, 2013

2007 – 2010

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Massachusetts General Hospital	Cambridge	Massachusetts	02138	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00592943, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 13, 2013 · Synced Nov 11, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00592943 live on ClinicalTrials.gov.

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