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Completed Phase 3 Interventional Results available

Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial

ClinicalTrials.gov ID: NCT00593450

Public ClinicalTrials.gov record NCT00593450. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Nov 2, 2026, 10:16 AM EST

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial (CATT)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the study is to evaluate the relative efficacy and safety of treatment of neovascular AMD with Lucentis on a fixed schedule, Avastin on a fixed schedule, Lucentis on a variable schedule, and Avastin on a variable schedule. A five year follow-up visit is being conducted in 2014 to gather information on long term outcomes.

Study identification

NCT ID
NCT00593450
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
University of Pennsylvania
Other
Enrollment
1,208 participants

Conditions and interventions

Eligibility (public fields only)

Age range
50 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 2008 (Actual)
Primary completion
Dec 2010 (Actual)
Completion
Apr 2015 (Actual)
Last update posted
Aug 21, 2017

2008 – 2015

United States locations

U.S. sites
59
U.S. states
26
U.S. cities
53
Facility City State ZIP Site status
Retina Consultants of Arizona Mesa Arizona 85210 —
Retinal Consultants of Arizona Phoenix Arizona 85064 —
Retina Associates Southwest, P.C. Tucson Arizona 85710 —
California Retina Consultants Bakersfield California 93309 —
Retina-Vitreous Associates Medical Group Beverly Hills California 90211 —
University of California-Davis Medical Center Sacramento California 95817 —
Retinal Consultants Medical Group, Inc. Sacramento California 95819 —
West Coast Retina Medical Group, Inc. San Francisco California 94107 —
California Retinal Consultants Santa Barbara California 93103 —
West Coast Retina Medical Group, Inc. Walnut Creek California 94596 —
Colorado Retina Associates Denver Colorado 80457 —
Retina Group of Florida Fort Lauderdale Florida 33334 —
National Ophthalmic Research Institute Fort Myers Florida 33912 —
Emory Eye Center Atlanta Georgia 30322 —
Illinois Retina Associates Flossmoor Illinois 60422 —
Ingalls Memorial Hospital/Illinois Retina Associates Harvey Illinois 60426 —
Illinois Retina Associates Joliet Illinois 60435 —
Midwest Eye Institute Indianapolis Indiana 46280 —
University of Iowa Hospitals and Clinics Iowa City Iowa 52242 —
Retina Associates of Kentucky Lexington Kentucky 40509 —
University of Louisville School of Medicine Louisville Kentucky 40202 —
Elman Retina Group, P.A. Baltimore Maryland 21237 —
The Retina Group of Washington Chevy Chase Maryland 20815 —
Retina Specialists Towson Maryland 21204 —
Massachusetts Eye & Ear Infirmary Boston Massachusetts 02114 —
Opthalmic Consultants of Boston Boston Massachusetts 02114 —
Harvard Vanguard Medical Associates Boston Massachusetts 02459 —
Vision Research Foundation/Associated Retinal Consultants, P.C. Grand Rapids Michigan 49546 —
Vision Research Foundation/Associated Retinal Consultants, P.C. Royal Oak Michigan 48073 —
Vision research Foundation/Associated Retinal Consultants. P.C. Traverse City Michigan 49684 —
VitreoRetinal Surgery Edina Minnesota 55435 —
Mayo Clinic Rochester Minnesota 55905 —
Barnes Retina Institute St Louis Missouri 63110 —
Retina Vitreous Center, PA New Brunswick New Jersey 08901 —
Retina Vitreous Center, PA Toms River New Jersey 08755 —
Long Island Vitreoretinal Consultants Great Neck New York 11021 —
Long Island Vitreoretinal Consultants Riverhead New York 11902 —
University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 —
Charlotte Eye, Ear, nose & Throat Associates Charlotte North Carolina 28210 —
Duke University Eye Center Durham North Carolina 27710 —
Charlotte Eye,Ear, Nose & Throat Associates Monroe North Carolina 28112 —
Retina Associates of Cleveland Beachwood Ohio 44122 —
Ohio State University Eye Physicians & Surgeons-Retina Division Dublin Ohio 43016 —
Retina Associates of Cleveland, Inc. Lakewood Ohio 44107 —
Dean A. McGee Eye Institute Oklahoma City Oklahoma 73104 —
Retina Northwest, P.C. Portland Oregon 97210 —
Casey Eye Institute Portland Oregon 97239 —
Retina Diagnostic and Treatment Associates, LLC Philadelphia Pennsylvania 19107 —
Retina Vitreous Consultants Pittsburgh Pennsylvania 15213 —
Palmetto Retina Center West Columbia South Carolina 29169 —
Southeastern Retina Associates Knoxville Tennessee 37920 —
Southeastern Retina Associates Knoxville Tennessee 38909 —
Retina Vitreous Associates, P.C. Nashville Tennessee 37203 —
Texas Retina Associates Arlington Texas 76012 —
Texas Retina Associates Dallas Texas 75231 —
Retina and Vitreous of Texas Houston Texas 77025 —
Vitreoretinal Consultants Houston Texas 77030 —
The Retina Group of Washington Fairfax Virginia 22310 —
University of Wisconsin Madison Wisconsin 53705 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00593450, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 21, 2017 · Synced Nov 2, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00593450 live on ClinicalTrials.gov.

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