ClinicalTrials.gov record
S0727 Gemcitabine Hydrochloride and Erlotinib Hydrochloride With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery
ClinicalTrials.gov ID: NCT00617708
Public ClinicalTrials.gov record NCT00617708. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I and Randomized Phase II Trial of Gemcitabine + Erlotinib (NSC-718781) + IMC-A12 (NSC-742460) vs. Gemcitabine + Erlotinib as First-Line Treatment in Patients With Metastatic Pancreatic Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase I/II trial is studying the side effects and best dose of monoclonal antibody therapy when given together with gemcitabine hydrochloride and erlotinib hydrochloride and to see how well they work compared with giving gemcitabine hydrochloride and erlotinib hydrochloride alone as first-line therapy in treating patients with metastatic pancreatic cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving erlotinib hydrochloride and gemcitabine hydrochloride together with monoclonal antibody therapy may kill more tumor cells.
Study identification
- NCT ID
- NCT00617708
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 134 participants
Conditions and interventions
Conditions
Interventions
- cixutumumab Biological
- erlotinib hydrochloride Drug
- gemcitabine hydrochloride Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2008 (Type not available)
- Primary completion
- Sep 1, 2012 (Actual)
- Completion
- Feb 25, 2014 (Actual)
- Last update posted
- Feb 8, 2022
2008 – 2014
United States locations
- U.S. sites
- 146
- U.S. states
- 23
- U.S. cities
- 92
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| NEA Baptist Memorial Hospital | Jonesboro | Arkansas | 72401 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Mills - Peninsula Hospitals | Burlingame | California | 94010 | — |
| East Bay Radiation Oncology Center | Castro Valley | California | 94546 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| Valley Medical Oncology Consultants-Castro Valley | Castro Valley | California | 94546 | — |
| City of Hope Medical Center | Duarte | California | 91010 | — |
| Valley Medical Oncology Consultants-Fremont | Fremont | California | 94538 | — |
| Glendale Memorial Hospital and Health Center | Glendale | California | 91204 | — |
| Marin General Hospital | Greenbrae | California | 94904 | — |
| Sutter Health Western Division Cancer Research Group | Greenbrae | California | 94904 | — |
| University of Southern California | Los Angeles | California | 90033-0804 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| El Camino Hospital | Mountain View | California | 94040 | — |
| Highland General Hospital | Oakland | California | 94602 | — |
| Alta Bates Summit Medical Center - Summit Campus | Oakland | California | 94609 | — |
| Bay Area Breast Surgeons Inc | Oakland | California | 94609 | — |
| Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Larry G Strieff MD Medical Corporation | Oakland | California | 94609 | — |
| Tom K Lee Inc | Oakland | California | 94609 | — |
| University of California Medical Center At Irvine-Orange Campus | Orange | California | 92868 | — |
| Valley Care Health System - Pleasanton | Pleasanton | California | 94588 | — |
| Valley Medical Oncology Consultants | Pleasanton | California | 94588 | — |
| California Pacific Medical Center | San Francisco | California | 94118 | — |
| Doctors Medical Center- JC Robinson Regional Cancer Center | San Pablo | California | 94806 | — |
| Sutter Solano Medical Center | Vallejo | California | 94589 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Atlanta Regional CCOP | Atlanta | Georgia | 30342 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Saint Joseph's Hospital of Atlanta | Atlanta | Georgia | 30342 | — |
| Well Star Cobb Hospital | Austell | Georgia | 30106 | — |
| John B Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Dekalb Medical Center | Decatur | Georgia | 30033 | — |
| Gwinnett Medical Center | Lawrenceville | Georgia | 30045 | — |
| Wellstar Kennestone Hospital | Marietta | Georgia | 30060 | — |
| Southern Regional Medical Center | Riverdale | Georgia | 30274 | — |
| Harbin Clinic Medical Oncology and Clinical Research | Rome | Georgia | 30165 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| Saint Joseph's-Candler Health System | Savannah | Georgia | 31405 | — |
| South Georgia Medical Center | Valdosta | Georgia | 31603 | — |
| Cancer Care Center of Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Saint Luke's South Hospital | Overland Park | Kansas | 66213 | — |
| Shawnee Mission Medical Center | Shawnee Mission | Kansas | 66204 | — |
| Christus Saint Frances Cabrini Hospital | Alexandria | Louisiana | 71301 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Mecosta County Medical Center | Big Rapids | Michigan | 49307 | — |
| Wayne State University | Detroit | Michigan | 48202 | — |
| Grand Rapids Clinical Oncology Program | Grand Rapids | Michigan | 49503 | — |
| Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| Mercy Health Partners-Mercy Campus | Muskegon | Michigan | 49444 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48073 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Metro Health Hospital | Wyoming | Michigan | 49519 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Truman Medical Center | Kansas City | Missouri | 64108 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Saint Joseph Health Center | Kansas City | Missouri | 64114 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | 64118 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | 64086 | — |
| Liberty Hospital | Liberty | Missouri | 64068 | — |
| Liberty Radiation Oncology Clinic | Liberty | Missouri | 64068 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Saint Joseph Oncology Inc | Saint Joseph | Missouri | 64507 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| Montana Cancer Consortium CCOP | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies PC | Billings | Montana | 59102 | — |
| Billings Clinic | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Berdeaux, Donald MD (UIA Investigator) | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Northern Montana Hospital | Havre | Montana | 59501 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Medical Oncology | Kalispell | Montana | 59901 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Hospital | Missoula | Montana | 59801 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Guardian Oncology and Center for Wellness | Missoula | Montana | 59804 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| Arnot Ogden Medical Center | Elmira | New York | 14905 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| Interlakes Foundation Inc-Rochester | Rochester | New York | 14623 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Randolph Hospital | Asheboro | North Carolina | 27203 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Presbyterian Hospital | Charlotte | North Carolina | 28204 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | — |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| Annie Penn Memorial Hospital | Reidsville | North Carolina | 27320 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| Veterans Administration Medical Center - Cincinnati | Cincinnati | Ohio | 45220 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| The Don and Sybil Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555-0565 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Ben Taub General Hospital | Houston | Texas | 77030 | — |
| Methodist Hospital | Houston | Texas | 77030 | — |
| Saint Luke's Episcopal Hospital | Houston | Texas | 77030 | — |
| Veterans Administration Medical Center | Houston | Texas | 77030 | — |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | — |
| American Fork Hospital | American Fork | Utah | 84003 | — |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | — |
| Logan Regional Hospital | Logan | Utah | 84321 | — |
| Intermountain Medical Center | Murray | Utah | 84157 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604-3337 | — |
| Intermountain Health Care | Salt Lake City | Utah | 84103 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | 84770 | — |
| Memorial Hospital Of Martinsville | Martinsville | Virginia | 24115 | — |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | — |
| Harrison Bremerton Hematology and Oncology | Bremerton | Washington | 98310 | — |
| Columbia Basin Hematology and Oncology PLLC | Kennewick | Washington | 99336 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| Harrison Poulsbo Hematology and Oncology | Poulsbo | Washington | 98370 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical PLLC | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | Seattle | Washington | 98109 | — |
| Group Health Cooperative | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122-4307 | — |
| The Polyclinic | Seattle | Washington | 98122 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology PS | Spokane | Washington | 99218 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00617708, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 8, 2022 · Synced Nov 11, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00617708 live on ClinicalTrials.gov.