Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer
Public ClinicalTrials.gov record NCT00625651. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1b/2 Study of AMG 655 in Combination With Modified FOLFOX6 and Bevacizumab for the First-Line Treatment of Subjects With Metastatic Colorectal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 1/2, multi-center, randomized, double-blind, placebo-controlled trial is designed to evaluate the efficacy and safety of AMG 655 when combined with mFOLFOX6 and bevacizumab compared with mFOLFOX6 and bevacizumab alone in subjects with previously untreated metastatic colorectal cancer (CRC). The clinical benefit of AMG 655 in combination with mFOLFOX6 and bevacizumab will be measured by progression-free survival, objective response rate, time to response, duration of response, and overall survival. This study is also designed to evaluate the safety and tolerability of AMG 655 in combination with mFOLFOX6 and bevacizumab and to evaluate anti-AMG 655 antibody formation and the pharmacokinetics of AMG 655.
Study identification
- NCT ID
- NCT00625651
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 202 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2007 (Type not available)
- Primary completion
- Aug 2010 (Actual)
- Completion
- Sep 2011 (Actual)
- Last update posted
- Apr 25, 2014
2007 – 2011
United States locations
- U.S. sites
- 61
- U.S. states
- 30
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Hot Springs | Arkansas | 71913 | — |
| Research Site | Downey | California | 90241 | — |
| Research Site | La Jolla | California | 92093-0957 | — |
| Research Site | Loma Linda | California | 92354 | — |
| Research Site | Orange | California | 92868 | — |
| Research Site | Rancho Mirage | California | 92270 | — |
| Research Site | San Diego | California | 92123 | — |
| Research Site | Denver | Colorado | 80218 | — |
| Research Site | Newark | Delaware | 19718 | — |
| Research Site | Washington D.C. | District of Columbia | 20007 | — |
| Research Site | Boca Raton | Florida | 33486 | — |
| Research Site | Kissimmee | Florida | 34741 | — |
| Research Site | Leesburg | Florida | 34788 | — |
| Research Site | Miami | Florida | 33136 | — |
| Research Site | Miami | Florida | 33176 | — |
| Research Site | Atlanta | Georgia | 30309 | — |
| Research Site | Lawrenceville | Georgia | 30045 | — |
| Research Site | Harvey | Illinois | 60426 | — |
| Research Site | Maywood | Illinois | 60153 | — |
| Research Site | Indianapolis | Indiana | 46227 | — |
| Research Site | Overland Park | Kansas | 66210 | — |
| Research Site | Louisville | Kentucky | 40202 | — |
| Research Site | Baltimore | Maryland | 21215 | — |
| Research Site | Baltimore | Maryland | 21237 | — |
| Research Site | Boston | Massachusetts | 02115 | — |
| Research Site | Ann Arbor | Michigan | 48106-0995 | — |
| Research Site | Saint Joseph | Michigan | 49085 | — |
| Research Site | Rochester | Minnesota | 55905 | — |
| Research Site | St Louis | Missouri | 63136 | — |
| Research Site | Great Falls | Montana | 59405 | — |
| Research Site | Long Branch | New Jersey | 07740 | — |
| Research Site | Albuquerque | New Mexico | 87109-4397 | — |
| Research Site | Buffalo | New York | 14263 | — |
| Research Site | Hudson | New York | 12534 | — |
| Research Site | New York | New York | 10021 | — |
| Research Site | The Bronx | New York | 10469 | — |
| Research Site | Asheville | North Carolina | 28801 | — |
| Research Site | Burlington | North Carolina | 27215 | — |
| Research Site | Gastonia | North Carolina | 28054 | — |
| Research Site | Raleigh | North Carolina | 27607 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Cincinnati | Ohio | 45226 | — |
| Research Site | Columbus | Ohio | 43219 | — |
| Research Site | Middletown | Ohio | 45042 | — |
| Research Site | Portland | Oregon | 97227 | — |
| Research Site | Harrisburg | Pennsylvania | 17109 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Pottsville | Pennsylvania | 17901 | — |
| Research Site | Greenville | South Carolina | 29605 | — |
| Research Site | Memphis | Tennessee | 38120 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Austin | Texas | 78731 | — |
| Research Site | Richardson | Texas | 75080 | — |
| Research Site | Tyler | Texas | 75702 | — |
| Research Site | Wichita Falls | Texas | 76310 | — |
| Research Site | Ogden | Utah | 84403 | — |
| Research Site | Fairfax | Virginia | 22031 | — |
| Research Site | Norfolk | Virginia | 23502 | — |
| Research Site | Richmond | Virginia | 23235 | — |
| Research Site | Tacoma | Washington | 98405 | — |
| Research Site | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00625651, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 25, 2014 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00625651 live on ClinicalTrials.gov.