ClinicalTrials.gov record
Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
ClinicalTrials.gov ID: NCT00628498
Public ClinicalTrials.gov record NCT00628498. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Single arm, open-label study to provide Defibrotide to patients diagnosed with VOD. Defibrotide is no longer available though the Emergency Use IND mechanism (also known as compassionate use, or single patient named use). This protocol is the only mechanism by which Defibrotide can be made available to patients in the U.S.
Study identification
- NCT ID
- NCT00628498
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,206 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2007 (Type not available)
- Primary completion
- Jul 2016 (Actual)
- Completion
- Sep 2016 (Actual)
- Last update posted
- Nov 30, 2017
2007 – 2016
United States locations
- U.S. sites
- 125
- U.S. states
- 41
- U.S. cities
- 90
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Alabama | Birmingham | Alabama | 35233 | — |
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | — |
| Mayo Clinic Cancer Center | Phoenix | Arizona | 85054 | — |
| Arizona Oncology | Scottsdale | Arizona | 85258 | — |
| University Medical Center | Tucson | Arizona | 85724 | — |
| University of Arkansas for Medical Services | Little Rock | Arkansas | 72205 | — |
| City of Hope Medical Center | Duarte | California | 91010 | — |
| The University of California, San Diego | La Jolla | California | 92037 | — |
| Loma Linda University | Loma Linda | California | 92354 | — |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Children's Hospital of Los Angeles | Los Angeles | California | 90027 | — |
| Children's Hospital & Research Center Oakland | Oakland | California | 94609 | — |
| Children's Hospital of Orange County (CHOC) | Orange | California | 92868 | — |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| University of California Davis Health System | Sacramento | California | 95817 | — |
| Rady's Children's Hospital - San Diego | San Diego | California | 92123 | — |
| University of California San Francisco Medical Center | San Francisco | California | 94143 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| US Oncology - Denver | Denver | Colorado | 80218 | — |
| Yale - New Haven Hospital | New Haven | Connecticut | 06520 | — |
| Nemours-Al duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| UF Health Shands Hospital | Gainesville | Florida | 32610 | — |
| Jackson Memorial- University of Miami Health System- Pediatrics | Miami | Florida | 33136 | — |
| Nicklaus Children's Hospital (Miami Children's Hospital) | Miami | Florida | 33155 | — |
| Florida Hospital | Orlando | Florida | 42803 | — |
| All Children's Hospital Specialty Physicians | St. Petersburg | Florida | 33701 | — |
| H. Lee Moffitt Cancer Center & Research Institute | Tampa | Florida | 33612 | — |
| Childrens Healthcare of Atlanta | Atlanta | Georgia | 30322 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Kapi'olani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | — |
| Northwest Memorial Hospital | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Pediatric Hematology/Oncology MC4060 - University of Chicago | Chicago | Illinois | 60637 | — |
| Cardinal Bernardin Cancer-Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Riley Hospital for Children | Indianapolis | Indiana | 46202 | — |
| Indiana Blood and Marrow Transplantation Clinical Lab LLC/St. Francis Hospital | Indianapolis | Indiana | 46237 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Pediatric Blood and Cancer Disorders Clinic | Louisville | Kentucky | 40202 | — |
| University of Louisville Research Foundation | Louisville | Kentucky | 40202 | — |
| Tulane University Hospital & Clinic (Tuhc) - Tulane Cancer Center Comprehensive Clinic (Tcccc) | New Orleans | Louisiana | 70112 | — |
| Children's Hospital | New Orleans | Louisiana | 70118 | — |
| University of Maryland - Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| National Institutes of Health | Bethesda | Maryland | 20892 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston Children's Hospital DFCI/CHB-Pediatrics | Boston | Massachusetts | 02115 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | — |
| Wayne State University/Children's Hospital of Michigan | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Helen DeVos Children's Hospital - Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| Children's Hospitals and Clinics of Minnesota and Minneapolis | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota Medical Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Children's Mercy Hospital and Clinics - Infectious Diseases | Kansas City | Missouri | 64108 | — |
| Cardinal Glennon Children's Medical Center/St. Louis University Department of Pediatrics | St Louis | Missouri | 63104 | — |
| Washington University/St. Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Hackensack University Medical Center - Joseph M. Sanzari Childrens Hospital | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Presbyterian Hospital | Albuquerque | New Mexico | 87106 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Steven and Alexandra Cohen Children's Medical Center | New Hyde Park | New York | 11040 | — |
| New York University School of Medicine | New York | New York | 10016 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10021 | — |
| Mount Sinai Hospital - BMT Program | New York | New York | 10029 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Morgan Stanley Children's Hospital - Columbia University Medical Center | New York | New York | 10032 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10065 | — |
| University of Rochester Medical Center, Strong Memorial Hospital | Rochester | New York | 14642 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Levine Children's Hospital | Charlotte | North Carolina | 28203 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Children's Hospital Medical | Akron | Ohio | 44308 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| The Jewish Hospital | Cincinnati | Ohio | 45236 | — |
| Case Western Reserve University (Cwru) - University Hospitals of Cleveland (Uhc) | Cleveland | Ohio | 44106 | — |
| Robert J Tomsich Pathology & Laboratory Medicine Institute | Cleveland | Ohio | 44195 | — |
| Nationwide Children's Hospital - Ohio State University College of Medicine (OSUCOM) | Columbus | Ohio | 43205 | — |
| The Ohio State University, James Cancer Hospital | Columbus | Ohio | 43210 | — |
| The University of Oklahoma Health Science Center | Oklahoma City | Oklahoma | 73104 | — |
| Doernbecher Children's Hospital - Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| The Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15219 | — |
| West Penn Allegheny Health System | Pittsburgh | Pennsylvania | 15224 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Greenville Health System Cancer Institute | Greenville | South Carolina | 29605 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Methodist University Hospital | Memphis | Tennessee | 38104 | — |
| St. Jude Children's Research Hospital - Department of Bone Marrow Transplantation and Cellular Therapy | Memphis | Tennessee | 38105 | — |
| The Children's Hospital at TriStar Centennial | Nashville | Tennessee | 37203 | — |
| Vanderbilt Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Children's Medical Center of Dallas | Dallas | Texas | 75235 | — |
| San Antonio Military Medical Center | Fort Sam Houston | Texas | 78234 | — |
| Cook Children's Health Care Hospital | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Texas Children's Hospital | Houston | Texas | 77030 | — |
| The University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Methodist Healthcare System of San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| Children's Hospital of the King's Daughter | Norfolk | Virginia | 23507 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Fred Hutchinson Cancer Research Center/Seattle Children Hospital | Seattle | Washington | 98109 | — |
| Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | 99204 | — |
| Mary Babb Randolph Cancer Center - West Virginia University Hospital | Morgantown | West Virginia | 26505 | — |
| University of Wisconsin, American Family Children's Hospital, Medical School | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin/ Children's Hospitalof Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00628498, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 30, 2017 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00628498 live on ClinicalTrials.gov.