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Completed Phase 2 Interventional

Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement

ClinicalTrials.gov ID: NCT00641732

Public ClinicalTrials.gov record NCT00641732. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 18, 2026, 4:14 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Randomized, Active Comparator-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to determine if TAK-442, once daily (QD) or twice daily (BID), is as safe and effective as enoxaparin in preventing the development of blood clots after knee replacement surgery.

Study identification

NCT ID
NCT00641732
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Lead sponsor
Takeda
Industry
Enrollment
1,045 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 2007 (Type not available)
Primary completion
Oct 2008 (Actual)
Completion
Oct 2008 (Actual)
Last update posted
Apr 13, 2016

2007 – 2008

United States locations

U.S. sites
38
U.S. states
17
U.S. cities
38
Facility City State ZIP Site status
Not listed Birmingham Alabama — —
Not listed Tuscaloosa Alabama — —
Not listed Phoenix Arizona — —
Not listed Little Rock Arkansas — —
Not listed Bakersfield California — —
Not listed Fountain Valley California — —
Not listed Long Beach California — —
Not listed Montclair California — —
Not listed Oceanside California — —
Not listed Vista California — —
Not listed Yuba City California — —
Not listed Aurora Colorado — —
Not listed Centennial Colorado — —
Not listed Denver Colorado — —
Not listed Bay Pines Florida — —
Not listed Clearwater Florida — —
Not listed DeLand Florida — —
Not listed Gulf Breeze Florida — —
Not listed Hollywood Florida — —
Not listed Pinellas Park Florida — —
Not listed Tamarac Florida — —
Not listed Atlanta Georgia — —
Not listed Boise Idaho — —
Not listed Meridian Idaho — —
Not listed Springfield Illinois — —
Not listed Towson Maryland — —
Not listed Charlotte North Carolina — —
Not listed Greensboro North Carolina — —
Not listed Cincinnati Ohio — —
Not listed Tulsa Oklahoma — —
Not listed Altoona Pennsylvania — —
Not listed Johnstown Pennsylvania — —
Not listed Charleston South Carolina — —
Not listed Dallas Texas — —
Not listed Grapenne Texas — —
Not listed Lubbock Texas — —
Not listed San Antonio Texas — —
Not listed Spokane Washington — —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00641732, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 13, 2016 · Synced Oct 18, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00641732 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →