A Study of Xeloda (Capecitabine) in Combination With Avastin + Short Course Chemotherapy in Patients With Metastatic Colorectal Cancer
Public ClinicalTrials.gov record NCT00642603. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open Label Study of the Effect of First Line Treatment With Xeloda in Combination With Avastin and Either Short Course Irinotecan or Short Course Oxaliplatin on Progression-free Survival in Patients With Metastatic Colorectal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This 2-arm study was designed to evaluate the efficacy and safety of 2 treatment regimens of Xeloda and Avastin, with either irinotecan or oxaliplatin administered for the first 12 cycles, as first line treatment in patients with metastatic colorectal cancer. Patients were randomized to receive 2-weekly cycles of treatment with either: 1) Xeloda, Avastin and oxaliplatin; or 2) Xeloda, Avastin and irinotecan. After 9 cycles, patients continued to receive maintenance treatment with Xeloda + Avastin. The anticipated time on study treatment was until disease progression, and the target sample size was 100-500 individuals.
Study identification
- NCT ID
- NCT00642603
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 41 participants
Conditions and interventions
Conditions
Interventions
- capecitabine [Xeloda] Drug
- bevacizumab [Avastin] Drug
- oxaliplatin Drug
- irinotecan Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2008 (Type not available)
- Primary completion
- Mar 2009 (Actual)
- Completion
- Mar 2009 (Actual)
- Last update posted
- Aug 26, 2026
2008 – 2009
United States locations
- U.S. sites
- 76
- U.S. states
- 28
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | PARK Springs | Arizona | 71913 | — |
| Not listed | Sedona | Arizona | 86336 | — |
| Not listed | Tucson | Arizona | 85712 | — |
| Not listed | Anaheim | California | 92801 | — |
| Not listed | Colton | California | 92324 | — |
| Not listed | Greenbrae | California | 94904 | — |
| Not listed | Loma Linda | California | 92354 | — |
| Not listed | Modesto | California | 95355 | — |
| Not listed | Montebello | California | 90640 | — |
| Not listed | Pomona | California | 91767 | — |
| Not listed | Sacramento | California | 95816 | — |
| Not listed | Norwich | Connecticut | 06360 | — |
| Not listed | Waterbury | Connecticut | 06708 | — |
| Not listed | Lake Worth | Florida | 33431 | — |
| Not listed | Miami Shores | Florida | 33179 | — |
| Not listed | New Port Richey | Florida | 34655 | — |
| Not listed | Ocala | Florida | 34474 | — |
| Not listed | Ocoee | Florida | 34761 | — |
| Not listed | Marietta | Georgia | 30060 | — |
| Not listed | Niles | Illinois | 60714 | — |
| Not listed | Paducah | Kentucky | 42002 | — |
| Not listed | Alexandria | Louisiana | 71301 | — |
| Not listed | Baltimore | Maryland | 21204 | — |
| Not listed | Baltimore | Maryland | 21237 | — |
| Not listed | Westminster | Maryland | 21157 | — |
| Not listed | Pittsfield | Massachusetts | 01201 | — |
| Not listed | Worcester | Massachusetts | 01608 | — |
| Not listed | Kalamazoo | Michigan | 49048 | — |
| Not listed | Duluth | Minnesota | 55805 | — |
| Not listed | Jefferson City | Missouri | 65109 | — |
| Not listed | Great Falls | Montana | 59405 | — |
| Not listed | Las Vegas | Nevada | 89109 | — |
| Not listed | Neptune City | New Jersey | 07754 | — |
| Not listed | Albuquerque | New Mexico | 87102 | — |
| Not listed | Albuquerque | New Mexico | 87131-5636 | — |
| Not listed | Santa Fe | New Mexico | 87505 | — |
| Not listed | Brooklyn | New York | 11219 | — |
| Not listed | Huntington Station | New York | 11746 | — |
| Not listed | Durham | North Carolina | 27710 | — |
| Not listed | Hickory | North Carolina | 28602 | — |
| Not listed | Canton | Ohio | 44718 | — |
| Not listed | Eugene | Oregon | 97401-8122 | — |
| Not listed | Ephrata | Pennsylvania | 17522 | — |
| Not listed | Langhorne | Pennsylvania | 19047 | — |
| Not listed | Philadelphia | Pennsylvania | 19102 | — |
| Not listed | Scranton | Pennsylvania | 18510 | — |
| Not listed | Charleston | South Carolina | 29403-5740 | — |
| Not listed | Charleston | South Carolina | 29406 | — |
| Not listed | Florence | South Carolina | 29506 | — |
| Not listed | Sumter | South Carolina | 29150 | — |
| Not listed | Chattanooga | Tennessee | 37404 | — |
| Not listed | Cookeville | Tennessee | 38501 | — |
| Not listed | Nashville | Tennessee | 37203 | — |
| Not listed | Amarillo | Texas | 79106 | — |
| Not listed | Arlington | Texas | 76014 | — |
| Not listed | Beaumont | Texas | 77702-1449 | — |
| Not listed | Bedford | Texas | 76022 | — |
| Not listed | Carrollton | Texas | 75010 | — |
| Not listed | Corpus Christi | Texas | 78412 | — |
| Not listed | Dallas | Texas | 75230 | — |
| Not listed | Dallas | Texas | 75231 | — |
| Not listed | Dallas | Texas | 75237 | — |
| Not listed | Fort Worth | Texas | 76104 | — |
| Not listed | Garland | Texas | 75042 | — |
| Not listed | Lewisville | Texas | 75067 | — |
| Not listed | Mesquite | Texas | 75150 | — |
| Not listed | Paris | Texas | 75460 | — |
| Not listed | Round Rock | Texas | 78681 | — |
| Not listed | San Antonio | Texas | 78229 | — |
| Not listed | Southlake | Texas | 76092 | — |
| Not listed | Sugarland | Texas | 77479 | — |
| Not listed | Waco | Texas | 76712 | — |
| Not listed | Webster | Texas | 77598-4420 | — |
| Not listed | Salt Lake City | Utah | 84106 | — |
| Not listed | Christiansburg | Virginia | 24073 | — |
| Not listed | Seattle | Washington | 98133 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00642603, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 26, 2026 · Synced Nov 10, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00642603 live on ClinicalTrials.gov.