APRiCOT-B: Study to Evaluate Apricoxib in Combination With Lapatinib and Capecitabine in the Treatment of HER2/Neu+ Breast Cancer (TP2001-202)
Public ClinicalTrials.gov record NCT00657137. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of the Efficacy and Safety of Apricoxib in Combination With Lapatinib and Capecitabine in the Treatment of Patients With HER2/Neu+ Breast Cancer Who Have Failed Trastuzumab and Chemotherapy Including a Taxane
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will compare the anti-tumor efficacy of apricoxib and lapatinib/capecitabine with placebo and lapatinib/capecitabine as measured by time to disease progression and evaluate urinary PGE-M measurements or baseline COX-2 expression in tumor tissue by IHC as a surrogate selection criterion for patients who will benefit from future treatment with apricoxib.
Study identification
- NCT ID
- NCT00657137
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 12 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2008 (Type not available)
- Primary completion
- Sep 2009 (Actual)
- Completion
- Sep 2009 (Actual)
- Last update posted
- Mar 15, 2012
2008 – 2009
United States locations
- U.S. sites
- 44
- U.S. states
- 20
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Clinical Research Center | Tucson | Arizona | — | — |
| Comprehensive Blood and Cancer Center | Bakersfield | California | — | — |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley | California | — | — |
| Bay Area Cancer Research Group, LLC | Concord | California | — | — |
| St. Jude Heritage Healthcare | Fullerton | California | — | — |
| Wilshire Oncology Medical Group Inc | Inland Valleys/Pomona | California | — | — |
| UCLA | Los Angeles | California | — | — |
| Olive View- UCLA Medical Center | Olive View | California | — | — |
| Cancer Care Associates Medical Group Inc | Redondo Beach | California | — | — |
| North America Research Institute | San Dimas | California | — | — |
| Central Coast Medical Oncology Corporation | Santa Maria | California | — | — |
| Front Range Cancer Specialists | Fort Collins | Colorado | — | — |
| Hematology Oncology Associates | Lake Worth | Florida | — | — |
| MD Anderson Cancer Center in Orlando | Orlando | Florida | — | — |
| Suburban Hematology-Oncology Associates | Lawrenceville | Georgia | — | — |
| Warren Billhartz Cancer Center | Maryville | Illinois | — | — |
| Mid-Illinois Hematology Oncology Associates | Normal | Illinois | — | — |
| Medical Consultants PC | Muncie | Indiana | — | — |
| SJMH Cancer Center | Ann Arbor | Michigan | — | — |
| Genesys Hurley Cancer Center Institute | Flint | Michigan | — | — |
| Foote Health System | Jackson County | Michigan | — | — |
| Bresline Cancer Center at Michigan State University | Lansing | Michigan | — | — |
| St. Mary Mercy Hospital | Livonia | Michigan | — | — |
| Mercy Hospital | Port Huron | Michigan | — | — |
| St. Mary's of Michigan | Saginaw | Michigan | — | — |
| St. Francis Cancer Treatment Center | Grand Island | Nebraska | — | — |
| Warren Hospital | Phillipsburg | New Jersey | — | — |
| San Juan Oncology Associates | Farmington | New Mexico | — | — |
| Flower Hospital Cancer Center | Sylvania | Ohio | — | — |
| University of Toledo | Toledo | Ohio | — | — |
| Samaritan Hematology and Oncology Consulting | Corvallis | Oregon | — | — |
| Providence Portland Medical Center | Portland | Oregon | — | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | — | — |
| Eastern Regional Medical Center | Philadelphia | Pennsylvania | — | — |
| Associates in Hematology-Oncology PC | Upland | Pennsylvania | — | — |
| Charleston Oncology Hematology Associates | Charleston | South Carolina | — | — |
| Baptist Regional Cancer Center | Knoxville | Tennessee | — | — |
| University of Texas Medical Branch | Galveston | Texas | — | — |
| Jabboury Foundation for Cancer Research Inc | Houston | Texas | — | — |
| The Methodist Hospital Research Institute | Houston | Texas | — | — |
| Fletcher Allen Healthcare Inc. | Burlington | Vermont | — | — |
| Community Cancer Center at Rutland Regional Medical Center | Rutland | Vermont | — | — |
| Peninsula Cancer Institute | Newport News | Virginia | — | — |
| Madigan Army Medical Center | Tacoma | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00657137, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 15, 2012 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00657137 live on ClinicalTrials.gov.