Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension
Public ClinicalTrials.gov record NCT00660179. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group, Event-driven, Phase III Study to Assess the Effects of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The AC-055-302/SERAPHIN study will be an event-driven Phase III study, comparing two different doses of macitentan (ACT-064992) (3 and 10 mg) vs placebo in patients with symptomatic PAH. The main study objective is to demonstrate that macitentan (ACT-064992) prolongs time to the first morbidity or mortality event, and to evaluate the benefit/risk profile of macitentan (ACT-064992) in the treatment of patients with symptomatic PAH.
Study identification
- NCT ID
- NCT00660179
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 742 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2008
- Primary completion
- Feb 29, 2012
- Completion
- Mar 31, 2012
- Last update posted
- Sep 27, 2015
2008 – 2012
United States locations
- U.S. sites
- 33
- U.S. states
- 25
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249-0001 | — |
| Arizona Pulmonary Specialists | Pheonix | Arizona | 85013 | — |
| GLVA Healthcare Center | Los Angeles | California | — | — |
| University of California, San Diego | San Diego | California | — | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | — | — |
| Liu Center for Pulmonary Hypertension | Torrance | California | — | — |
| University of Colorado Health Sciences Center | Denver | Colorado | — | — |
| Mayo Clinic, Jacksonville | Jacksonville | Florida | — | — |
| Emory University Hospital - McKelvey Center for Lung Transplantation & Pulmonary Vascular Disease | Atlanta | Georgia | 30322 | — |
| Pulmonary & Critical Care of Atlanta | Atlanta | Georgia | 30342 | — |
| Southeastern Lung Care | Decatur | Georgia | — | — |
| University of Chicago Hospitals | Chicago | Illinois | — | — |
| University of Iowa | Iowa City | Iowa | — | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Kentuckiana Pulmonary Associate, PLLC | Louisville | Kentucky | — | — |
| Medical Center of Louisiana at New Orleans | New Orleans | Louisiana | — | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Boston University School of Medicine | Boston | Massachusetts | — | — |
| Pulmonary/Critical Care Division/Tufts New England Medical Center | Boston | Massachusetts | — | — |
| University of Michigan | Ann Arbor | Michigan | — | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of NJ - Robert Wood Johnson Medical School | New Brunswick | New Jersey | — | — |
| Columbia University Medical Center - Pediatric Cardiology | New York | New York | — | — |
| Duke University Medical Center | Durham | North Carolina | — | — |
| University of Cincinnati Ohio Heart Health Center | Cincinnati | Ohio | — | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | — | — |
| University of Texas Medical Center - St. Paul University | Dallas | Texas | 75235 | — |
| Baylor College of Medicine and the Methodist Hospital | Houston | Texas | 77030 | — |
| Dept. of Pulmonary Medicine - Latter Day Saints Hospital | Salt Lake City | Utah | — | — |
| Sentara Hospital T/A Sentara Cardiovascular Research Institute | Norfolk | Virginia | 23507 | — |
| Comprehensive Cardiovascular Care Group | Milwaukee | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 120 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00660179, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 27, 2015 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00660179 live on ClinicalTrials.gov.