Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension
Public ClinicalTrials.gov record NCT00667823. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Long-term Single-arm Open-label Extension Study of the SERAPHIN Study, to Assess the Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main objective of the AC 055 303/SERAPHIN OL study, which will follow the AC 055 302/SERAPHIN study, will be to assess the long-term safety and tolerability of ACT 064992 in patients with symptomatic PAH.
Study identification
- NCT ID
- NCT00667823
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 550 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 17, 2008 (Actual)
- Primary completion
- Dec 7, 2020 (Actual)
- Completion
- Dec 7, 2020 (Actual)
- Last update posted
- Mar 30, 2025
2008 – 2020
United States locations
- U.S. sites
- 39
- U.S. states
- 27
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249-0001 | — |
| Arizona Pulmonary Specialists | Phoenix | Arizona | 85012 | — |
| University of California, San Diego | La Jolla | California | 92037 | — |
| GLVA Healthcare Center | Los Angeles | California | 90073 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93105 | — |
| Liu Center for Pulmonary Hypertension | Torrance | California | 90502-2006 | — |
| University of Colorado CARDIAC AND VASCULAR CENTER | Aurora | Colorado | 80045-2548 | — |
| University of Florida - Division of Pulmonology | Gainesville | Florida | 32610 | — |
| Mayo Clinic, Jacksonville | Jacksonville | Florida | 32259 | — |
| Emory University Hospital - McKelvey Center for Lung Transplantation & Pulmonary Vascular Disease | Atlanta | Georgia | 30322 | — |
| Pulmonary & Critical Care of Atlanta | Atlanta | Georgia | 30342-1713 | — |
| Atlanta Institute for Medical Research | Decatur | Georgia | 30030 | — |
| University of Chicago | Chicago | Illinois | 60637-1432 | — |
| University of Iowa, Pulmonary Hypertension Program | Iowa City | Iowa | 52242-1081 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Kentuckiana Pulmonary Associate, PLLC | Louisville | Kentucky | 40202 | — |
| Louisiana State University Health Sciences Center | New Orleans | Louisiana | 70112-1393 | — |
| Maine Medical Center | Portland | Maine | 04102-3134 | — |
| University of Maryland School of Medicine; Division of Cardiology | Baltimore | Maryland | 21201-1544 | — |
| Pulmonary/Critical Care Division/Tufts New England Medical Center | Boston | Massachusetts | 02111-1552 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Harper Univ. Hospital/ Wayne State University | Detroit | Michigan | 48201 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110-1010 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| University of NJ - Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903-0010 | — |
| Columbia University Medical Center - Pediatric Cardiology | New York | New York | 10032 | — |
| Duke University Medical Center | Durham | North Carolina | 27710-0001 | — |
| University of Cincinnati Ohio Heart Health Center | Cincinnati | Ohio | 45219-2906 | — |
| Ohio State University, Div. of Pul. & Critical Care | Columbus | Ohio | 43210 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Medical Center - St. Paul University | Dallas | Texas | 75390-8550 | — |
| Baylor College of Medicine and the Methodist Hospital, | Houston | Texas | 77030 | — |
| University of Texas Houston Health Center | Houston | Texas | 77030 | — |
| Intermountain Med Ctr- Pulm Dept Heart and Lung Ctr | Murray | Utah | 84157-5701 | — |
| Sentara Hospitals T/A Sentara Cardiovascular Research Intitute | Norfolk | Virginia | 23507-1904 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53125 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 119 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00667823, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 30, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00667823 live on ClinicalTrials.gov.