Safety and Efficacy Study of 4975 in Patients Undergoing Total Knee Replacement
Public ClinicalTrials.gov record NCT00681356. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Placebo-Controlled, Parallel-Group, Double-Blind Study to Evaluate the Efficacy, Tolerability, Safety, and Pharmacokinetics of 4975 in Patients Undergoing Primary Unilateral Total Knee Arthroplasty
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Evaluate the efficacy, tolerability, safety, and pharmacokinetics of 4975 in patients undergoing total knee replacement
Study identification
- NCT ID
- NCT00681356
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 214 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2007 (Type not available)
- Primary completion
- Sep 2008 (Actual)
- Completion
- Dec 2008 (Actual)
- Last update posted
- May 4, 2009
2007 – 2008
United States locations
- U.S. sites
- 25
- U.S. states
- 12
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Clinical Therapeutics, LLC | Birmingham | Alabama | 35235 | — |
| Springhill Medical Center | Mobile | Alabama | 36608 | — |
| Hellen Keller Hospital | Sheffield | Alabama | 35660 | — |
| Visions Clinical Research/Tucson Medical Center | Tucson | Arizona | 85712 | — |
| Glendale Adventist Medical Center - Lotus Clinical Research | Glendale | California | 91206 | — |
| Physicians Clinical Research Corporation | Laguna Hills | California | 92653 | — |
| Saddleback Memorial Medical Center/Accurate Clinical Trials | Laguna Hills | California | 92653 | — |
| Webster Orthopeadic Medical Group | Oakland | California | 94612 | — |
| UCSF-Mt. Zion Medical Center | San Francisco | California | 94115 | — |
| Orthopedic Associates of Hartford | Hartford | Connecticut | 06106 | — |
| Florida Hospital - Florida Research Associates, LLC | DeLand | Florida | 32720 | — |
| University of Miami, Miller School of Medicine | Miami | Florida | 33136 | — |
| Miami Institute for Medical Research | Miami | Florida | 33186 | — |
| Southeastern Clinical Research Consultants | Orlando | Florida | 32804 | — |
| Coastal Medical Research | Port Orange | Florida | 32127 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Ruxton Professional Center - Orthopaedic Associates | Towson | Maryland | 21204 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48085 | — |
| William Beaumont Hospital | Troy | Michigan | 48085 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Sewickley Valley Hospital | Sewickley | Pennsylvania | 15143 | — |
| Presbyterian Hospital of Dallas | Dallas | Texas | 75231 | — |
| Memorial City Hospital - Memorial Hermann Healthcare System | Houston | Texas | 77024 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00681356, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2009 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00681356 live on ClinicalTrials.gov.