A New Method for Determining Gastric Acid Output Using a Wireless Capsule
Public ClinicalTrials.gov record NCT00702533. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Background: \- Acid-related gastrointestinal disorders are numerous and may require chronic treatment and maintenance, but they are often difficult to diagnose and treat. Gastric analysis is a critical tool for diagnosing and treating acid-related disorders; however, at present it requires a technically difficult procedure, using a nasogastric tube, that is costly, invasive, and uncomfortable. Recently a new tool, the SmartPill, has been developed that can measure acid levels, temperature, and pressure throughout the stomach, small intestine, and colon by swallowing a small capsule. Researchers are interested in comparing current methods of measuring stomach acid with the SmartPill by studying both healthy volunteers and individuals with acid-related gastrointestinal disorders. Objectives: \- To evaluate the usefulness and accuracy of the SmartPill for gastric analysis, compared with current procedures. Eligibility: * Phase 1A/1B: Healthy volunteers between 18 and 60 years of age. * Phase 2: Individuals at least 18 years of age who have been diagnosed with Zollinger-Ellison Syndrome or acid hypersecretion. * Phase 3: Individuals at least 18 years of age who have been diagnosed with refractory gastroesophageal reflux disease, peptic ulcer disease, or idiopathic gastric hypersecretion. Design: * This study involves a screening visit, a 3-day inpatient study visit, and possible additional outpatient visits. * Participants will be screened with a medical history and physical examination, as well as blood and urine samples. * Phase 1A/1B: Participants will have a 3-day inpatient study visit with the following procedures: * Imaging study of the stomach (simultaneous gastric emptying scintigraphy), followed by a special diet for the next day s test. * Gastric analysis using a nasogastric tube to collect stomach acid secretions. * SmartPill study, in which participants will ingest a SmartPill and wear a monitor for 24 to 48 hours to collect readings. * Participants in Phase 1A will have a second outpatient SmartPill study 7 days after the first SmartPill study. Participants in Phase 1B will not have the second SmartPill study. * Phase 2 and Phase 3: Participants will have a 3-day inpatient study visit with the following procedures: * Imaging study of the stomach (simultaneous gastric emptying scintigraphy), followed by a special diet for the next day s test. * Gastric analysis using a nasogastric tube to collect stomach acid secretions. * SmartPill study, in which participants will ingest a SmartPill and wear a monitor for 24 to 48 hours to collect readings. * Phase 2 and 3 participants will have outpatient study visits only if directed by the study researchers.
Study identification
- NCT ID
- NCT00702533
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 80 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 17, 2008
- Primary completion
- Not listed
- Completion
- Not listed
- Last update posted
- Aug 30, 2026
Started 2008
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Institutes of Health Clinical Center | Bethesda | Maryland | 20892 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00702533, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 30, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00702533 live on ClinicalTrials.gov.