Phase III Study of Docetaxel + Ramucirumab or Placebo in Breast Cancer
Public ClinicalTrials.gov record NCT00703326. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Multinational, Randomized, Double-Blind, Phase III Study of IMC-1121B Plus Docetaxel Versus Placebo Plus Docetaxel in Previously Untreated Patients With HER2-Negative, Unresectable, Locally-Recurrent or Metastatic Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this study is to compare the progression-free survival (PFS) of the drug combination ramucirumab plus docetaxel to placebo plus docetaxel in previously untreated participants with human epidermal growth factor receptor 2 (HER2)-negative, unresectable, locally-recurrent or metastatic breast cancer.
Study identification
- NCT ID
- NCT00703326
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,144 participants
Conditions and interventions
Conditions
Interventions
- ramucirumab (IMC-1121B) Biological
- docetaxel Drug
- Placebo Other
Biological · Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 6, 2008 (Actual)
- Primary completion
- Mar 31, 2013 (Actual)
- Completion
- Nov 19, 2020 (Actual)
- Last update posted
- Dec 6, 2021
2008 – 2020
United States locations
- U.S. sites
- 65
- U.S. states
- 24
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ImClone Investigational Site | Birmingham | Alabama | 35202 | — |
| ImClone Investigational Site | Mobile | Alabama | 36608 | — |
| ImClone Investigational Site | Chandler | Arizona | 85224 | — |
| ImClone Investigational Site | Gilbert | Arizona | 85297 | — |
| ImClone Investigational Site | Mesa | Arizona | 85206 | — |
| ImClone Investigational Site | Alhambra | California | 91801 | — |
| ImClone Investigational Site | Bakersfield | California | 93309 | — |
| ImClone Investigational Site | Chula Vista | California | 91911 | — |
| ImClone Investigational Site | La Mesa | California | 91942 | — |
| ImClone Investigational Site | Los Angeles | California | 90095 | — |
| ImClone Investigational Site | Oceanside | California | 92056 | — |
| ImClone Investigational Site | Pasadena | California | 01107 | — |
| ImClone Investigational Site | Pasadena | California | 91105 | — |
| ImClone Investigational Site | San Diego | California | 92123 | — |
| ImClone Investigational Site | Santa Barbara | California | 93105 | — |
| ImClone Investigational Site | Santa Maria | California | 93454 | — |
| ImClone Investigational Site | Santa Monica | California | 90404 | — |
| ImClone Investigational Site | Solvang | California | 93463 | — |
| ImClone Investigational Site | Valencia | California | 91355 | — |
| ImClone Investigational Site | Aurora | Colorado | 80045 | — |
| ImClone Investigational Site | Fort Lauderdale | Florida | 33308 | — |
| ImClone Investigational Site | Gainesville | Florida | 32605 | — |
| ImClone Investigational Site | New Port Richey | Florida | 34655 | — |
| ImClone Investigational Site | Atlanta | Georgia | 30341 | — |
| ImClone Investigational Site | Atlanta | Georgia | 30342 | — |
| ImClone Investigational Site | Macon | Georgia | 31217 | — |
| ImClone Investigational Site | Marietta | Georgia | 30060 | — |
| ImClone Investigational Site | Alton | Illinois | 62002 | — |
| ImClone Investigational Site | Chicago | Illinois | 60076 | — |
| ImClone Investigational Site | Chicago | Illinois | 60611 | — |
| ImClone Investigational Site | Skokie | Illinois | 60076 | — |
| ImClone Investigational Site | Elkhart | Indiana | 46514 | — |
| ImClone Investigational Site | Mishawaka | Indiana | 46545 | — |
| ImClone Investigational Site | South Bend | Indiana | 46601 | — |
| ImClone Investigational Site | Westville | Indiana | 46891 | — |
| ImClone Investigational Site | Lexington | Kentucky | 40604 | — |
| ImClone Investigational Site | Lansing | Michigan | 48912 | — |
| ImClone Investigational Site | Saint Joseph | Michigan | 49085 | — |
| ImClone Investigational Site | Minneapolis | Minnesota | 55415 | — |
| ImClone Investigational Site | Southaven | Mississippi | 38671 | — |
| ImClone Investigational Site | St Louis | Missouri | 63136 | — |
| ImClone Investigational Site | Grand Island | Nebraska | 68803 | — |
| ImClone Investigational Site | Kearney | Nebraska | 68845 | — |
| ImClone Investigational Site | Henderson | Nevada | 89052 | — |
| ImClone Investigational Site | New York | New York | 10011 | — |
| ImClone Investigational Site | Charlotte | North Carolina | 15830 | — |
| ImClone Investigational Site | Charlotte | North Carolina | 28203 | — |
| ImClone Investigational Site | Charlotte | North Carolina | 28210 | — |
| ImClone Investigational Site | Charlotte | North Carolina | 28211 | — |
| ImClone Investigational Site | Charlotte | North Carolina | 28262 | — |
| ImClone Investigational Site | Charlotte | North Carolina | 28294 | — |
| ImClone Investigational Site | Bismarck | North Dakota | 58501 | — |
| ImClone Investigational Site | Oklahoma City | Oklahoma | 73120 | — |
| ImClone Investigational Site | Portland | Oregon | 97239 | — |
| ImClone Investigational Site | West Reading | Pennsylvania | 19611 | — |
| ImClone Investigational Site | Bartlett | Tennessee | 38133 | — |
| ImClone Investigational Site | Germantown | Tennessee | 38138 | — |
| ImClone Investigational Site | Memphis | Tennessee | 38104 | — |
| ImClone Investigational Site | Memphis | Tennessee | 38119 | — |
| ImClone Investigational Site | Memphis | Tennessee | 38120 | — |
| ImClone Investigational Site | Niles | Tennessee | 49120 | — |
| ImClone Investigational Site | Oxford | Tennessee | 38655 | — |
| ImClone Investigational Site | Lubbock | Texas | 79410 | — |
| ImClone Investigational Site | Temple | Texas | 76508 | — |
| ImClone Investigational Site | Salt Lake City | Utah | 84106 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 167 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00703326, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 6, 2021 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00703326 live on ClinicalTrials.gov.