Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

ClinicalTrials.gov ID: NCT00709865

Public ClinicalTrials.gov record NCT00709865. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 29, 2026, 8:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Safety and Tolerability of Intravenous Tonapofylline in Subjects With Acute Decompensated Heart Failure and Renal Insufficiency

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the current study is to assess the safety and tolerability of intravenous tonapofylline.

Study identification

NCT ID: NCT00709865
Recruitment status: Completed
Study type: Interventional
Phase: Phase 3
Lead sponsor: Biogen; Industry
Enrollment: 420 participants

Conditions and interventions

Conditions

Interventions

tonapofylline Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 31, 2008 (Actual)
Primary completion: Oct 30, 2009 (Actual)
Completion: Dec 31, 2009 (Actual)
Last update posted: Sep 11, 2023

2008 – 2009

United States locations

U.S. sites: 68
U.S. states: 29
U.S. cities: 67

Facility	City	State	ZIP	Site status
Not listed	Huntsville	Alabama	35801	—
Not listed	Mobile	Alabama	36608	—
Not listed	Fort Smith	Arkansas	72917	—
Not listed	Beverly Hills	California	90210	—
Not listed	Chula Vista	California	91911	—
Not listed	Mission Viejo	California	92691	—
Not listed	Monterey Park	California	91754	—
Not listed	Oceanside	California	92056	—
Not listed	Redondo Beach	California	90277	—
Not listed	San Diego	California	92103	—
Not listed	Sylmar	California	91342	—
Not listed	Torrance	California	90502	—
Not listed	Yuba City	California	95991	—
Not listed	Hartford	Connecticut	06102	—
Not listed	Jacksonville	Florida	32216	—
Not listed	Sarasota	Florida	34239	—
Not listed	Tampa	Florida	33613	—
Not listed	Lombard	Illinois	60148	—
Not listed	Indianapolis	Indiana	46202	—
Not listed	Muncie	Indiana	47303	—
Not listed	Iowa City	Iowa	52242	—
Not listed	Kansas City	Kansas	64132	—
Not listed	Wichita	Kansas	67220	—
Not listed	Baltimore	Maryland	21201	—
Not listed	Ayer	Massachusetts	01432	—
Not listed	Boston	Massachusetts	02114	—
Not listed	Hyannis	Massachusetts	02601	—
Not listed	Springfield	Massachusetts	01107	—
Not listed	West Springfield	Massachusetts	01089	—
Not listed	Traverse City	Michigan	49684	—
Not listed	Minneapolis	Minnesota	55404	—
Not listed	Kansas City	Missouri	64132	—
Not listed	Lee's Summit	Missouri	64063	—
Not listed	St Louis	Missouri	63128	—
Not listed	Omaha	Nebraska	68131	—
Not listed	Ridgewood	New Jersey	07450	—
Not listed	Johnson City	New York	13790	—
Not listed	Mineola	New York	11501	—
Not listed	New York	New York	10021	—
Not listed	Stony Brook	New York	11794	—
Not listed	The Bronx	New York	10461	—
Not listed	Concord	North Carolina	28025	—
Not listed	Cincinnati	Ohio	45267	—
Not listed	Cleveland	Ohio	44195	—
Not listed	Columbus	Ohio	43210	—
Not listed	Franklin	Ohio	45005	—
Not listed	Oklahoma City	Oklahoma	73109	—
Not listed	Oklahoma City	Oklahoma	73120	—
Not listed	Tulsa	Oklahoma	74104	—
Not listed	Portland	Oregon	97213	—
Not listed	Camp Hill	Pennsylvania	17011	—
Not listed	Danville	Pennsylvania	17822	—
Not listed	Doylestown	Pennsylvania	18901	—
Not listed	Lancaster	Pennsylvania	17603	—
Not listed	Philadelphia	Pennsylvania	19140	—
Not listed	Providence	Rhode Island	02908	—
Not listed	Orangeburg	South Carolina	29118	—
Not listed	Nashville	Tennessee	37208	—
Not listed	Oak Ridge	Tennessee	37830	—
Not listed	Tullahoma	Tennessee	37388	—
Not listed	Dallas	Texas	75216	—
Not listed	Houston	Texas	77030	—
Not listed	San Antonio	Texas	78215	—
Not listed	Whitney	Texas	76692	—
Not listed	Danville	Virginia	24541	—
Not listed	Olympia	Washington	98506	—
Not listed	Tacoma	Washington	98405	—
Not listed	Charleston	West Virginia	25304	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 121 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00709865, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 11, 2023 · Synced Oct 29, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00709865 live on ClinicalTrials.gov.

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