Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)
Public ClinicalTrials.gov record NCT00712426. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Huntington's disease (HD) is a slowly progressive disorder that devastates the lives of those affected and their families. There are no treatments that slow the progression of HD, only mildly effective symptomatic therapies are available.Creatine monohydrate is considered a nutritional supplement. The purpose of CREST-E is to test whether high-dose creatine can slow the progressive functional decline that occurs in persons 18 years or older with early clinical features of HD. The long-term safety, tolerability and effectiveness of up to 40 grams daily creatine compared to placebo is studied. A variety of biological processes are assessed for markers of disease activity or progression and creatine effects. Up to 50 active research centers globally will enroll 650 subjects.
Study identification
- NCT ID
- NCT00712426
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 553 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2009 (Type not available)
- Primary completion
- Dec 2014 (Actual)
- Completion
- Jan 2015 (Actual)
- Last update posted
- Mar 11, 2016
2009 – 2015
United States locations
- U.S. sites
- 38
- U.S. states
- 27
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | — |
| University of California, Irvine | Irvine | California | 92697 | — |
| University of California Davis | Sacramento | California | 95817 | — |
| University of Connecticut | Farmington | Connecticut | 06030 | — |
| University of Florida (McKnight Brain Institute) | Gainesville | Florida | 32610 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30329 | — |
| Georgia Regents University | Augusta | Georgia | 30329 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Indiana University | Indianapolis | Indiana | 27157 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Hereditary Neurological Disease Center (HNDC) | Wichita | Kansas | 67206 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02129 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Struthers Parkinson's Center | Golden Valley | Minnesota | 55427 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| North Shore-LIJ Health System | Manhasset | New York | 11030 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester | Rochester | New York | 14618 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15260 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| University of Tennessee Health Science Center | Memphis | Tennessee | 38163 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84108 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| Booth Gardner Parkinson's Care Center (Evergreen Healthcare) | Kirkland | Washington | 98034 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00712426, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 11, 2016 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00712426 live on ClinicalTrials.gov.