Study Of Letrozole With Or Without Palbociclib (PD-0332991) For The First-Line Treatment Of Hormone-Receptor Positive Advanced Breast Cancer
Public ClinicalTrials.gov record NCT00721409. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PHASE 1/2, OPEN-LABEL, RANDOMIZED STUDY OF THE SAFETY, EFFICACY, AND PHARMACOKINETICS OF LETROZOLE PLUS PD 0332991 (ORAL CDK 4/6 INHIBITOR) AND LETROZOLE SINGLE AGENT FOR THE FIRST-LINE TREATMENT OF ER POSITIVE, HER2 NEGATIVE ADVANCED BREAST CANCER IN POSTMENOPAUSAL WOMEN
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study is aimed to confirm that letrozole + PD 0332991 is safe and tolerable and to assess the effect of the combination on advanced breast cancer
Study identification
- NCT ID
- NCT00721409
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 177 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 15, 2008 (Actual)
- Primary completion
- Nov 29, 2013 (Actual)
- Completion
- Dec 20, 2017 (Actual)
- Last update posted
- Nov 4, 2019
2008 – 2017
United States locations
- U.S. sites
- 51
- U.S. states
- 6
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Hematology Oncology Medical group Inc. | Alhambra | California | 91801 | — |
| UCLA Hematology/Oncology - Alhambra | Alhambra | California | 91801 | — |
| CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| UCLA West Medical Pharmacy (Drug Management Only) | Los Angeles | California | 90095-1772 | — |
| UCLA West Medical Pharmacy | Los Angeles | California | 90095-1772 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095-6984 | — |
| UCLA West Medical Pharmacy | Los Angeles | California | 90095-7349 | — |
| Drug Management Only: UCLA West Medical Pharmacy | Los Angeles | California | 90095 | — |
| Drug Management Only | Los Angeles | California | 90095 | — |
| Regulatory Managment | Los Angeles | California | 90095 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | — |
| TORI -US Central Administration (Regulatory Management) | Los Angeles | California | 90095 | — |
| TORI -US Central Administration | Los Angeles | California | 90095 | — |
| TORI Central Administration (Regulatory Management) | Los Angeles | California | 90095 | — |
| TORI Central Administration (Regulatory Managment Only) | Los Angeles | California | 90095 | — |
| TRIO-US Central Administration | Los Angeles | California | 90095 | — |
| UCLA Hematology/Oncology | Los Angeles | California | 90095 | — |
| UCLA, Hematology/Oncology | Los Angeles | California | 90095 | — |
| Westwood Bowyer Clinic, Peter Morton Medical Building | Los Angeles | California | 90095 | — |
| Central Hematology Oncology Medical Group, Inc | Pasadena | California | 91107 | — |
| Torrance Health Association, DBA Torrance Memorial Physician Network/Cancer Care Associates | Redondo Beach | California | 90277 | — |
| Sansum Santa Barbara Medical Foundation Clinic | Santa Barbara | California | 93105 | — |
| Central Coast Medical Oncology Corporation | Santa Maria | California | 93454 | — |
| Santa Monica-UCLA Medical Center and Orthopaedic Hospital | Santa Monica | California | 90404 | — |
| UCLA Hematology Oncology-Santa Monica | Santa Monica | California | 90404 | — |
| UCLA Hematology/Oncology - Santa Clarita | Valencia | California | 91355 | — |
| Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care | Duluth | Georgia | 30096 | — |
| Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care | Lawrenceville | Georgia | 30046 | — |
| Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care | Snellville | Georgia | 30078 | — |
| Illinois Cancer Specialists | Chicago | Illinois | 60611 | — |
| Resurrection Medical Group | Chicago | Illinois | 60657 | — |
| North Shore Oncology-Hematology Associates | Crystal Lake | Illinois | 60014 | — |
| North Shore Hematology Oncology | Highland Park | Illinois | 60035 | — |
| North Shore Oncology-Hematology Associates | Libertyville | Illinois | 60048 | — |
| North Shore Hematology Oncology | Skokie | Illinois | 60077 | — |
| Regulatory Office: Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89014 | — |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89052 | — |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89074 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89128 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| Texas Oncology-Dallas Presbyterian Hospital | Dallas | Texas | 75231 | — |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| Investigational Products Center (IPC) | Fort Worth | Texas | 76177 | — |
| US Oncology Research and Clinical Pharmacy | Fort Worth | Texas | 76177 | — |
| Virginia Cancer Specialists, PC | Arlington | Virginia | 22205 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | — |
| Virginia Cancer Specialists, PC | Leesburg | Virginia | 20176 | — |
| Virginia Cancer Specialists, PC | Woodbridge | Virginia | 22191 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00721409, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 4, 2019 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00721409 live on ClinicalTrials.gov.